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PMC:1315279 / 6336-7492 JSONTXT 5 Projects

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Id Subject Object Predicate Lexical cue
T1694 0-5 NN denotes Sam68
T1696 6-9 VBD denotes was
T1695 10-20 VBN denotes identified
T1697 21-23 IN denotes as
T1698 24-26 DT denotes an
T1700 27-30 NN denotes SH3
T1701 31-34 CC denotes and
T1702 35-38 NN denotes SH2
T1703 39-45 NN denotes domain
T1704 46-57 VBG denotes interacting
T1699 58-65 NN denotes protein
T1705 66-69 IN denotes for
T1706 70-73 NN denotes Src
T1708 74-80 NN denotes family
T1707 81-88 NNS denotes kinases
T1709 89-92 CC denotes and
T1710 93-95 VBZ denotes is
T1711 96-100 RB denotes also
T1712 101-102 DT denotes a
T1714 103-108 JJ denotes known
T1713 109-118 NN denotes substrate
T1715 119-121 IN denotes of
T1716 122-125 NN denotes Src
T1717 126-133 NNS denotes kinases
T1718 134-135 -LRB- denotes [
T1719 135-137 CD denotes 39
T1720 137-138 SYM denotes –
T1721 138-140 CD denotes 42
T1722 140-141 -RRB- denotes ]
T1723 142-145 CC denotes and
T1724 146-148 IN denotes of
T1725 149-152 DT denotes the
T1727 153-159 NN denotes breast
T1728 160-165 NN denotes tumor
T1726 166-172 NN denotes kinase
T1729 173-174 -LRB- denotes [
T1730 174-176 CD denotes 43
T1731 176-177 -RRB- denotes ]
T1732 177-178 . denotes .
T1733 178-292 sentence denotes Sam68 has been shown to facilitate the export of unspliced HIV RNA [44] and to regulate pre-mRNA processing [45].
T1734 179-184 NN denotes Sam68
T1736 185-188 VBZ denotes has
T1737 189-193 VBN denotes been
T1735 194-199 VBN denotes shown
T1738 200-202 TO denotes to
T1739 203-213 VB denotes facilitate
T1740 214-217 DT denotes the
T1741 218-224 NN denotes export
T1742 225-227 IN denotes of
T1743 228-237 JJ denotes unspliced
T1745 238-241 NN denotes HIV
T1744 242-245 NN denotes RNA
T1746 246-247 -LRB- denotes [
T1747 247-249 CD denotes 44
T1748 249-250 -RRB- denotes ]
T1749 251-254 CC denotes and
T1750 255-257 TO denotes to
T1751 258-266 VB denotes regulate
T1752 267-275 NN denotes pre-mRNA
T1753 276-286 NN denotes processing
T1754 287-288 -LRB- denotes [
T1755 288-290 CD denotes 45
T1756 290-291 -RRB- denotes ]
T1757 291-292 . denotes .
T1758 292-398 sentence denotes In the present paper, we report the generation of Sam68−/− mice and analysis of their skeletal phenotype.
T1759 293-295 IN denotes In
T1761 296-299 DT denotes the
T1763 300-307 JJ denotes present
T1762 308-313 NN denotes paper
T1764 313-315 , denotes ,
T1765 315-317 PRP denotes we
T1760 318-324 VBP denotes report
T1766 325-328 DT denotes the
T1767 329-339 NN denotes generation
T1768 340-342 IN denotes of
T1769 343-348 NN denotes Sam68
T1771 348-349 SYM denotes −
T1772 349-350 HYPH denotes /
T1773 350-351 SYM denotes −
T1770 352-356 NNS denotes mice
T1774 357-360 CC denotes and
T1775 361-369 NN denotes analysis
T1776 370-372 IN denotes of
T1777 373-378 PRP$ denotes their
T1779 379-387 JJ denotes skeletal
T1778 388-397 NN denotes phenotype
T1780 397-398 . denotes .
T1781 398-572 sentence denotes Our data indicate that the absence of Sam68 confers resistance to age-related bone loss in mice such that old Sam68 have a higher bone mass than their wild-type littermates.
T1782 399-402 PRP$ denotes Our
T1783 403-407 NNS denotes data
T1784 408-416 VBP denotes indicate
T1785 417-421 IN denotes that
T1787 422-425 DT denotes the
T1788 426-433 NN denotes absence
T1789 434-436 IN denotes of
T1790 437-442 NN denotes Sam68
T1786 443-450 VBZ denotes confers
T1791 451-461 NN denotes resistance
T1792 462-464 IN denotes to
T1793 465-468 NN denotes age
T1795 468-469 HYPH denotes -
T1794 469-476 VBN denotes related
T1797 477-481 NN denotes bone
T1796 482-486 NN denotes loss
T1798 487-489 IN denotes in
T1799 490-494 NNS denotes mice
T1800 495-499 JJ denotes such
T1802 500-504 IN denotes that
T1803 505-508 JJ denotes old
T1804 509-514 NN denotes Sam68
T1801 515-519 VBP denotes have
T1805 520-521 DT denotes a
T1807 522-528 JJR denotes higher
T1808 529-533 NN denotes bone
T1806 534-538 NN denotes mass
T1809 539-543 IN denotes than
T1810 544-549 PRP$ denotes their
T1812 550-554 JJ denotes wild
T1814 554-555 HYPH denotes -
T1813 555-559 NN denotes type
T1811 560-571 NNS denotes littermates
T1815 571-572 . denotes .
T1816 572-831 sentence denotes We provide evidence that Sam68 regulates the differentiation of bone marrow stromal cells by showing that cells isolated from Sam68−/− animals had enhanced osteogenic activity and decreased adipogenic activity than those harvested from wild-type littermates.
T1817 573-575 PRP denotes We
T1818 576-583 VBP denotes provide
T1819 584-592 NN denotes evidence
T1820 593-597 IN denotes that
T1822 598-603 NN denotes Sam68
T1821 604-613 VBZ denotes regulates
T1823 614-617 DT denotes the
T1824 618-633 NN denotes differentiation
T1825 634-636 IN denotes of
T1826 637-641 NN denotes bone
T1827 642-648 NN denotes marrow
T1829 649-656 JJ denotes stromal
T1828 657-662 NNS denotes cells
T1830 663-665 IN denotes by
T1831 666-673 VBG denotes showing
T1832 674-678 IN denotes that
T1834 679-684 NNS denotes cells
T1835 685-693 VBN denotes isolated
T1836 694-698 IN denotes from
T1837 699-704 NN denotes Sam68
T1839 704-705 SYM denotes −
T1840 705-706 HYPH denotes /
T1841 706-707 SYM denotes −
T1838 708-715 NNS denotes animals
T1833 716-719 VBD denotes had
T1842 720-728 VBN denotes enhanced
T1844 729-739 JJ denotes osteogenic
T1843 740-748 NN denotes activity
T1845 749-752 CC denotes and
T1846 753-762 VBN denotes decreased
T1848 763-773 JJ denotes adipogenic
T1847 774-782 NN denotes activity
T1849 783-787 IN denotes than
T1850 788-793 DT denotes those
T1851 794-803 VBN denotes harvested
T1852 804-808 IN denotes from
T1853 809-813 JJ denotes wild
T1855 813-814 HYPH denotes -
T1854 814-818 NN denotes type
T1856 819-830 NNS denotes littermates
T1857 830-831 . denotes .
T1858 831-1040 sentence denotes Furthermore, Sam68−/− mouse embryo fibroblasts (MEFs) were impaired in their capacity to differentiate into adipocytes, consistent with Sam68 being a regulator of bone marrow mesenchymal cell differentiation.
T1859 832-843 RB denotes Furthermore
T1861 843-845 , denotes ,
T1862 845-850 NN denotes Sam68
T1863 850-851 SYM denotes −
T1864 851-852 HYPH denotes /
T1865 852-853 SYM denotes −
T1866 854-859 NN denotes mouse
T1867 860-866 NN denotes embryo
T1868 867-878 NNS denotes fibroblasts
T1869 879-880 -LRB- denotes (
T1870 880-884 NNS denotes MEFs
T1871 884-885 -RRB- denotes )
T1872 886-890 VBD denotes were
T1860 891-899 VBN denotes impaired
T1873 900-902 IN denotes in
T1874 903-908 PRP$ denotes their
T1875 909-917 NN denotes capacity
T1876 918-920 TO denotes to
T1877 921-934 VB denotes differentiate
T1878 935-939 IN denotes into
T1879 940-950 NNS denotes adipocytes
T1880 950-952 , denotes ,
T1881 952-962 JJ denotes consistent
T1882 963-967 IN denotes with
T1883 968-973 NN denotes Sam68
T1884 974-979 VBG denotes being
T1885 980-981 DT denotes a
T1886 982-991 NN denotes regulator
T1887 992-994 IN denotes of
T1888 995-999 NN denotes bone
T1889 1000-1006 NN denotes marrow
T1891 1007-1018 JJ denotes mesenchymal
T1892 1019-1023 NN denotes cell
T1890 1024-1039 NN denotes differentiation
T1893 1039-1040 . denotes .
T1894 1040-1156 sentence denotes These results also characterize a new animal model to study bone metabolism, regeneration, and repair during aging.
T1895 1041-1046 DT denotes These
T1896 1047-1054 NNS denotes results
T1898 1055-1059 RB denotes also
T1897 1060-1072 VBP denotes characterize
T1899 1073-1074 DT denotes a
T1901 1075-1078 JJ denotes new
T1902 1079-1085 NN denotes animal
T1900 1086-1091 NN denotes model
T1903 1092-1094 TO denotes to
T1904 1095-1100 VB denotes study
T1905 1101-1105 NN denotes bone
T1906 1106-1116 NN denotes metabolism
T1907 1116-1118 , denotes ,
T1908 1118-1130 NN denotes regeneration
T1909 1130-1132 , denotes ,
T1910 1132-1135 CC denotes and
T1911 1136-1142 NN denotes repair
T1912 1143-1149 IN denotes during
T1913 1150-1155 NN denotes aging
T1914 1155-1156 . denotes .
R1000 T1712 T1713 det a,substrate
R1001 T1765 T1760 nsubj we,report
R1002 T1766 T1767 det the,generation
R1003 T1767 T1760 dobj generation,report
R1004 T1768 T1767 prep of,generation
R1005 T1713 T1710 attr substrate,is
R1006 T1769 T1770 nmod Sam68,mice
R1007 T1770 T1768 pobj mice,of
R1008 T1714 T1713 amod known,substrate
R1009 T1771 T1769 punct −,Sam68
R1010 T1772 T1769 punct /,Sam68
R1011 T1773 T1769 punct −,Sam68
R1012 T1774 T1767 cc and,generation
R1013 T1775 T1767 conj analysis,generation
R1014 T1776 T1775 prep of,analysis
R1015 T1777 T1778 poss their,phenotype
R1016 T1715 T1713 prep of,substrate
R1017 T1778 T1776 pobj phenotype,of
R1018 T1779 T1778 amod skeletal,phenotype
R1019 T1780 T1760 punct .,report
R1020 T1716 T1717 compound Src,kinases
R1021 T1782 T1783 poss Our,data
R1022 T1717 T1715 pobj kinases,of
R1023 T1783 T1784 nsubj data,indicate
R1024 T1785 T1786 mark that,confers
R1025 T1718 T1719 punct [,39
R1026 T1786 T1784 ccomp confers,indicate
R1027 T1787 T1788 det the,absence
R1028 T1719 T1717 parataxis 39,kinases
R1029 T1788 T1786 nsubj absence,confers
R1030 T1789 T1788 prep of,absence
R1031 T1790 T1789 pobj Sam68,of
R1032 T1720 T1721 punct –,42
R1033 T1791 T1786 dobj resistance,confers
R1034 T1792 T1791 prep to,resistance
R1035 T1793 T1794 npadvmod age,related
R1036 T1826 T1827 nmod bone,marrow
R1037 T1794 T1796 amod related,loss
R1038 T1795 T1794 punct -,related
R1039 T1796 T1792 pobj loss,to
R1040 T1797 T1796 compound bone,loss
R1041 T1798 T1786 prep in,confers
R1042 T1799 T1798 pobj mice,in
R1043 T1827 T1828 nmod marrow,cells
R1044 T1800 T1801 amod such,have
R1045 T1801 T1786 advcl have,confers
R1046 T1802 T1801 mark that,have
R1047 T1828 T1825 pobj cells,of
R1048 T1803 T1804 amod old,Sam68
R1049 T1804 T1801 nsubj Sam68,have
R1050 T1805 T1806 det a,mass
R1051 T1829 T1828 amod stromal,cells
R1052 T1806 T1801 dobj mass,have
R1053 T1807 T1806 amod higher,mass
R1054 T1808 T1806 compound bone,mass
R1055 T1830 T1818 prep by,provide
R1056 T1809 T1806 prep than,mass
R1057 T1810 T1811 poss their,littermates
R1058 T1811 T1809 pobj littermates,than
R1059 T1831 T1830 pcomp showing,by
R1060 T1812 T1813 amod wild,type
R1061 T1813 T1811 compound type,littermates
R1062 T1814 T1813 punct -,type
R1063 T1815 T1784 punct .,indicate
R1064 T1817 T1818 nsubj We,provide
R1065 T1832 T1833 mark that,had
R1066 T1819 T1818 dobj evidence,provide
R1067 T1820 T1821 mark that,regulates
R1068 T1833 T1831 ccomp had,showing
R1069 T1821 T1819 acl regulates,evidence
R1070 T1822 T1821 nsubj Sam68,regulates
R1071 T1823 T1824 det the,differentiation
R1072 T1834 T1833 nsubj cells,had
R1073 T1824 T1821 dobj differentiation,regulates
R1074 T1825 T1824 prep of,differentiation
R1075 T1835 T1834 acl isolated,cells
R1076 T1836 T1835 prep from,isolated
R1077 T1837 T1838 nmod Sam68,animals
R1078 T1838 T1836 pobj animals,from
R1079 T1839 T1837 punct −,Sam68
R1080 T1840 T1837 punct /,Sam68
R1081 T1841 T1837 punct −,Sam68
R1082 T1842 T1843 amod enhanced,activity
R1083 T1843 T1833 dobj activity,had
R1084 T1844 T1843 amod osteogenic,activity
R1085 T1845 T1843 cc and,activity
R1086 T1846 T1847 amod decreased,activity
R1087 T1847 T1843 conj activity,activity
R1088 T1848 T1847 amod adipogenic,activity
R1089 T1849 T1843 prep than,activity
R1090 T1850 T1849 pobj those,than
R1091 T1851 T1850 acl harvested,those
R1092 T1852 T1851 prep from,harvested
R1093 T1853 T1854 amod wild,type
R1094 T1854 T1856 compound type,littermates
R1095 T1855 T1854 punct -,type
R1096 T1856 T1852 pobj littermates,from
R1097 T1857 T1818 punct .,provide
R1098 T1859 T1860 advmod Furthermore,impaired
R1099 T1861 T1860 punct ", ",impaired
R1100 T1862 T1860 nsubjpass Sam68,impaired
R1101 T1863 T1862 punct −,Sam68
R1102 T1864 T1862 punct /,Sam68
R1103 T1865 T1862 punct −,Sam68
R1104 T1866 T1867 compound mouse,embryo
R1105 T1867 T1868 compound embryo,fibroblasts
R1106 T1868 T1862 appos fibroblasts,Sam68
R1107 T1869 T1868 punct (,fibroblasts
R1108 T1870 T1868 appos MEFs,fibroblasts
R1109 T1871 T1862 punct ),Sam68
R1110 T1872 T1860 auxpass were,impaired
R1111 T1873 T1860 prep in,impaired
R1112 T1874 T1875 poss their,capacity
R1113 T1875 T1873 pobj capacity,in
R1114 T1876 T1877 aux to,differentiate
R1115 T1877 T1875 acl differentiate,capacity
R1116 T1878 T1877 prep into,differentiate
R1117 T1879 T1878 pobj adipocytes,into
R1118 T1880 T1860 punct ", ",impaired
R1119 T1881 T1860 advcl consistent,impaired
R1120 T1882 T1881 prep with,consistent
R1121 T1883 T1884 nsubj Sam68,being
R1122 T1884 T1882 pcomp being,with
R1123 T1885 T1886 det a,regulator
R1124 T1886 T1884 attr regulator,being
R1125 T1887 T1886 prep of,regulator
R1126 T1888 T1889 nmod bone,marrow
R1127 T1889 T1890 nmod marrow,differentiation
R1128 T1890 T1887 pobj differentiation,of
R1129 T1891 T1890 amod mesenchymal,differentiation
R1130 T1892 T1890 compound cell,differentiation
R1131 T1893 T1860 punct .,impaired
R1132 T1895 T1896 det These,results
R1133 T1896 T1897 nsubj results,characterize
R1134 T1898 T1897 advmod also,characterize
R1135 T1899 T1900 det a,model
R1136 T1900 T1897 dobj model,characterize
R1137 T1901 T1900 amod new,model
R1138 T1902 T1900 compound animal,model
R1139 T1903 T1904 aux to,study
R1140 T1904 T1900 advcl study,model
R1141 T1905 T1906 compound bone,metabolism
R1142 T1906 T1904 dobj metabolism,study
R1143 T1907 T1906 punct ", ",metabolism
R1144 T1908 T1906 conj regeneration,metabolism
R1145 T1909 T1908 punct ", ",regeneration
R1146 T1910 T1908 cc and,regeneration
R1147 T1911 T1908 conj repair,regeneration
R1148 T1912 T1904 prep during,study
R1149 T1913 T1912 pobj aging,during
R1150 T1914 T1897 punct .,characterize
R943 T1721 T1719 prep 42,39
R944 T1694 T1695 nsubjpass Sam68,identified
R945 T1722 T1719 punct ],39
R946 T1723 T1715 cc and,of
R947 T1724 T1715 conj of,of
R948 T1725 T1726 det the,kinase
R949 T1696 T1695 auxpass was,identified
R950 T1726 T1724 pobj kinase,of
R951 T1727 T1728 compound breast,tumor
R952 T1728 T1726 compound tumor,kinase
R953 T1729 T1730 punct [,43
R954 T1697 T1695 prep as,identified
R955 T1730 T1726 parataxis 43,kinase
R956 T1731 T1730 punct ],43
R957 T1698 T1699 det an,protein
R958 T1732 T1695 punct .,identified
R959 T1734 T1735 nsubjpass Sam68,shown
R960 T1736 T1735 aux has,shown
R961 T1737 T1735 auxpass been,shown
R962 T1699 T1697 pobj protein,as
R963 T1738 T1739 aux to,facilitate
R964 T1700 T1699 nmod SH3,protein
R965 T1739 T1735 xcomp facilitate,shown
R966 T1701 T1700 cc and,SH3
R967 T1702 T1700 conj SH2,SH3
R968 T1740 T1741 det the,export
R969 T1703 T1699 nmod domain,protein
R970 T1741 T1739 dobj export,facilitate
R971 T1704 T1699 amod interacting,protein
R972 T1742 T1741 prep of,export
R973 T1743 T1744 amod unspliced,RNA
R974 T1744 T1742 pobj RNA,of
R975 T1705 T1695 prep for,identified
R976 T1745 T1744 compound HIV,RNA
R977 T1746 T1747 punct [,44
R978 T1747 T1739 parataxis 44,facilitate
R979 T1706 T1707 compound Src,kinases
R980 T1748 T1747 punct ],44
R981 T1749 T1739 cc and,facilitate
R982 T1750 T1751 aux to,regulate
R983 T1707 T1705 pobj kinases,for
R984 T1751 T1739 conj regulate,facilitate
R985 T1752 T1753 compound pre-mRNA,processing
R986 T1708 T1707 compound family,kinases
R987 T1753 T1751 dobj processing,regulate
R988 T1754 T1755 punct [,45
R989 T1755 T1751 parataxis 45,regulate
R990 T1709 T1695 cc and,identified
R991 T1756 T1755 punct ],45
R992 T1757 T1735 punct .,shown
R993 T1759 T1760 prep In,report
R994 T1710 T1695 conj is,identified
R995 T1761 T1762 det the,paper
R996 T1711 T1710 advmod also,is
R997 T1762 T1759 pobj paper,In
R998 T1763 T1762 amod present,paper
R999 T1764 T1760 punct ", ",report