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PMC:1255741 / 5654-6779 JSONTXT 5 Projects

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Id Subject Object Predicate Lexical cue
T1496 0-10 VBG denotes Concerning
T1498 11-15 DT denotes this
T1500 16-24 VBN denotes intended
T1499 25-31 NN denotes switch
T1501 32-34 IN denotes in
T1502 35-40 NN denotes AMPAR
T1503 41-51 NNS denotes properties
T1504 51-53 , denotes ,
T1505 53-57 NNS denotes mice
T1506 58-65 VBG denotes lacking
T1507 66-69 DT denotes all
T1509 70-74 NN denotes GluR
T1510 74-75 HYPH denotes -
T1508 75-76 NN denotes B
T1511 76-78 , denotes ,
T1512 78-85 RB denotes however
T1513 85-87 , denotes ,
T1497 87-91 VBP denotes show
T1514 92-93 DT denotes a
T1516 94-104 JJ denotes widespread
T1515 105-115 NN denotes impairment
T1517 116-118 IN denotes in
T1518 119-127 NN denotes behavior
T1519 127-129 , denotes ,
T1520 129-138 VBG denotes including
T1521 139-147 NN denotes lethargy
T1522 147-149 , denotes ,
T1523 149-154 NN denotes motor
T1524 155-167 NN denotes coordination
T1525 168-176 NNS denotes problems
T1526 176-178 , denotes ,
T1527 178-181 CC denotes and
T1528 182-190 NNS denotes deficits
T1529 191-193 IN denotes in
T1530 194-205 JJ denotes exploratory
T1531 206-214 NN denotes activity
T1532 215-216 -LRB- denotes [
T1533 216-218 CD denotes 51
T1534 218-219 -RRB- denotes ]
T1535 219-221 , denotes ,
T1536 221-226 WDT denotes which
T1537 227-235 VBP denotes preclude
T1538 236-244 JJ denotes detailed
T1540 245-255 JJ denotes behavioral
T1539 256-264 NNS denotes analyses
T1541 264-265 . denotes .
T1542 265-435 sentence denotes Similarly, mice expressing (in the entire brain) a substantial part of the GluR-B population in the Q/R site-unedited form become seizure-prone and die prematurely [53].
T1543 266-275 RB denotes Similarly
T1545 275-277 , denotes ,
T1546 277-281 NNS denotes mice
T1547 282-292 VBG denotes expressing
T1548 293-294 -LRB- denotes (
T1549 294-296 IN denotes in
T1550 297-300 DT denotes the
T1552 301-307 JJ denotes entire
T1551 308-313 NN denotes brain
T1553 313-314 -RRB- denotes )
T1554 315-316 DT denotes a
T1556 317-328 JJ denotes substantial
T1555 329-333 NN denotes part
T1557 334-336 IN denotes of
T1558 337-340 DT denotes the
T1560 341-345 NN denotes GluR
T1562 345-346 HYPH denotes -
T1561 346-347 NN denotes B
T1559 348-358 NN denotes population
T1563 359-361 IN denotes in
T1564 362-365 DT denotes the
T1566 366-367 NN denotes Q
T1568 367-368 HYPH denotes /
T1567 368-369 NN denotes R
T1569 370-374 NN denotes site
T1571 374-375 HYPH denotes -
T1570 375-383 JJ denotes unedited
T1565 384-388 NN denotes form
T1544 389-395 VBP denotes become
T1572 396-403 NN denotes seizure
T1574 403-404 HYPH denotes -
T1573 404-409 JJ denotes prone
T1575 410-413 CC denotes and
T1576 414-417 VBP denotes die
T1577 418-429 RB denotes prematurely
T1578 430-431 -LRB- denotes [
T1579 431-433 CD denotes 53
T1580 433-434 -RRB- denotes ]
T1581 434-435 . denotes .
T1582 435-754 sentence denotes Some of these problems can be partially overcome by use of spatially and temporally restricted expression systems [54–56], in particular the Cre-lox system, with Cre-recombinase expression in defined brain areas of gene-targeted mice carrying GluR-B alleles marked by loxP sites for Cre-mediated recombination [55,57].
T1583 436-440 DT denotes Some
T1585 441-443 IN denotes of
T1586 444-449 DT denotes these
T1587 450-458 NNS denotes problems
T1588 459-462 MD denotes can
T1589 463-465 VB denotes be
T1590 466-475 RB denotes partially
T1584 476-484 VBN denotes overcome
T1591 485-487 IN denotes by
T1592 488-491 NN denotes use
T1593 492-494 IN denotes of
T1594 495-504 RB denotes spatially
T1596 505-508 CC denotes and
T1597 509-519 RB denotes temporally
T1595 520-530 VBN denotes restricted
T1599 531-541 NN denotes expression
T1598 542-549 NNS denotes systems
T1600 550-551 -LRB- denotes [
T1601 551-553 CD denotes 54
T1602 553-554 SYM denotes –
T1603 554-556 CD denotes 56
T1604 556-557 -RRB- denotes ]
T1605 557-559 , denotes ,
T1606 559-561 IN denotes in
T1608 562-572 JJ denotes particular
T1609 573-576 DT denotes the
T1610 577-580 NN denotes Cre
T1612 580-581 HYPH denotes -
T1611 581-584 NN denotes lox
T1607 585-591 NN denotes system
T1613 591-593 , denotes ,
T1614 593-597 IN denotes with
T1616 598-601 NN denotes Cre
T1618 601-602 HYPH denotes -
T1617 602-613 NN denotes recombinase
T1619 614-624 NN denotes expression
T1620 625-627 IN denotes in
T1621 628-635 VBN denotes defined
T1623 636-641 NN denotes brain
T1622 642-647 NNS denotes areas
T1624 648-650 IN denotes of
T1625 651-655 NN denotes gene
T1627 655-656 HYPH denotes -
T1626 656-664 VBN denotes targeted
T1628 665-669 NNS denotes mice
T1629 670-678 VBG denotes carrying
T1630 679-683 NN denotes GluR
T1632 683-684 HYPH denotes -
T1631 684-685 NN denotes B
T1633 686-693 NNS denotes alleles
T1615 694-700 VBN denotes marked
T1634 701-703 IN denotes by
T1635 704-708 NN denotes loxP
T1636 709-714 NNS denotes sites
T1637 715-718 IN denotes for
T1638 719-722 NN denotes Cre
T1640 722-723 HYPH denotes -
T1639 723-731 VBN denotes mediated
T1641 732-745 NN denotes recombination
T1642 746-747 -LRB- denotes [
T1218 747-749 CD denotes 55
T1644 749-750 , denotes ,
T1643 750-752 CD denotes 57
T1645 752-753 -RRB- denotes ]
T1646 753-754 . denotes .
T1647 754-914 sentence denotes Indeed, restricting the expression of Q/R site-unedited GluR-B to forebrain resulted in almost normal lifespan and an only weakly seizure-prone phenotype [58].
T1648 755-761 RB denotes Indeed
T1650 761-763 , denotes ,
T1651 763-774 VBG denotes restricting
T1652 775-778 DT denotes the
T1653 779-789 NN denotes expression
T1654 790-792 IN denotes of
T1655 793-794 NN denotes Q
T1657 794-795 HYPH denotes /
T1656 795-796 NN denotes R
T1659 797-801 NN denotes site
T1661 801-802 HYPH denotes -
T1660 802-810 JJ denotes unedited
T1662 811-815 NN denotes GluR
T1663 815-816 HYPH denotes -
T1658 816-817 NN denotes B
T1664 818-820 IN denotes to
T1665 821-830 NN denotes forebrain
T1649 831-839 VBD denotes resulted
T1666 840-842 IN denotes in
T1667 843-849 RB denotes almost
T1668 850-856 JJ denotes normal
T1669 857-865 NN denotes lifespan
T1670 866-869 CC denotes and
T1671 870-872 DT denotes an
T1673 873-877 RB denotes only
T1674 878-884 RB denotes weakly
T1676 885-892 NN denotes seizure
T1677 892-893 HYPH denotes -
T1675 893-898 JJ denotes prone
T1672 899-908 NN denotes phenotype
T1678 909-910 -LRB- denotes [
T1679 910-912 CD denotes 58
T1680 912-913 -RRB- denotes ]
T1681 913-914 . denotes .
T1682 914-1125 sentence denotes Mice with forebrain-specific GluR-B depletion appeared almost completely normal throughout life with no developmental abnormalities, thus permitting a detailed, quantitative investigation of olfactory behavior.
T1683 915-919 NNS denotes Mice
T1685 920-924 IN denotes with
T1686 925-934 NN denotes forebrain
T1688 934-935 HYPH denotes -
T1687 935-943 JJ denotes specific
T1690 944-948 NN denotes GluR
T1692 948-949 HYPH denotes -
T1691 949-950 NN denotes B
T1689 951-960 NN denotes depletion
T1684 961-969 VBD denotes appeared
T1693 970-976 RB denotes almost
T1694 977-987 RB denotes completely
T1695 988-994 JJ denotes normal
T1696 995-1005 IN denotes throughout
T1697 1006-1010 NN denotes life
T1698 1011-1015 IN denotes with
T1699 1016-1018 DT denotes no
T1701 1019-1032 JJ denotes developmental
T1700 1033-1046 NNS denotes abnormalities
T1702 1046-1048 , denotes ,
T1703 1048-1052 RB denotes thus
T1704 1053-1063 VBG denotes permitting
T1705 1064-1065 DT denotes a
T1707 1066-1074 VBN denotes detailed
T1708 1074-1076 , denotes ,
T1709 1076-1088 JJ denotes quantitative
T1706 1089-1102 NN denotes investigation
T1710 1103-1105 IN denotes of
T1711 1106-1115 JJ denotes olfactory
T1712 1116-1124 NN denotes behavior
T1713 1124-1125 . denotes .
R1033 T1496 T1497 prep Concerning,show
R1034 T1499 T1496 pobj switch,Concerning
R1036 T1500 T1499 amod intended,switch
R1037 T1498 T1499 det this,switch
R1038 T1502 T1503 compound AMPAR,properties
R1039 T1501 T1499 prep in,switch
R1040 T1504 T1497 punct ", ",show
R1041 T1505 T1497 nsubj mice,show
R1042 T1503 T1501 pobj properties,in
R1043 T1507 T1508 det all,B
R1044 T1506 T1505 acl lacking,mice
R1045 T1509 T1508 compound GluR,B
R1046 T1510 T1508 punct -,B
R1047 T1508 T1506 dobj B,lacking
R1048 T1512 T1497 advmod however,show
R1049 T1511 T1497 punct ", ",show
R1050 T1514 T1515 det a,impairment
R1051 T1515 T1497 dobj impairment,show
R1052 T1513 T1497 punct ", ",show
R1053 T1517 T1515 prep in,impairment
R1054 T1516 T1515 amod widespread,impairment
R1055 T1519 T1515 punct ", ",impairment
R1056 T1520 T1515 prep including,impairment
R1057 T1518 T1517 pobj behavior,in
R1058 T1522 T1521 punct ", ",lethargy
R1059 T1523 T1524 compound motor,coordination
R1060 T1521 T1520 pobj lethargy,including
R1061 T1525 T1521 conj problems,lethargy
R1062 T1526 T1525 punct ", ",problems
R1063 T1524 T1525 compound coordination,problems
R1064 T1528 T1525 conj deficits,problems
R1065 T1529 T1528 prep in,deficits
R1066 T1527 T1525 cc and,problems
R1067 T1531 T1529 pobj activity,in
R1068 T1530 T1531 amod exploratory,activity
R1069 T1533 T1528 parataxis 51,deficits
R1070 T1534 T1533 punct ],51
R1071 T1532 T1533 punct [,51
R1072 T1536 T1537 dep which,preclude
R1073 T1537 T1528 relcl preclude,deficits
R1074 T1535 T1528 punct ", ",deficits
R1075 T1539 T1537 dobj analyses,preclude
R1076 T1538 T1539 amod detailed,analyses
R1077 T1541 T1497 punct .,show
R1078 T1540 T1539 amod behavioral,analyses
R1079 T1543 T1544 advmod Similarly,become
R1080 T1546 T1544 nsubj mice,become
R1081 T1547 T1546 acl expressing,mice
R1082 T1548 T1547 punct (,expressing
R1083 T1549 T1547 prep in,expressing
R1084 T1545 T1544 punct ", ",become
R1085 T1551 T1549 pobj brain,in
R1086 T1552 T1551 amod entire,brain
R1087 T1550 T1551 det the,brain
R1088 T1554 T1555 det a,part
R1089 T1553 T1547 punct ),expressing
R1090 T1556 T1555 amod substantial,part
R1091 T1555 T1547 dobj part,expressing
R1092 T1558 T1559 det the,population
R1093 T1559 T1557 pobj population,of
R1094 T1557 T1555 prep of,part
R1095 T1561 T1559 compound B,population
R1096 T1562 T1561 punct -,B
R1097 T1560 T1561 compound GluR,B
R1098 T1564 T1565 det the,form
R1099 T1563 T1547 prep in,expressing
R1100 T1566 T1567 nmod Q,R
R1101 T1567 T1565 nmod R,form
R1102 T1565 T1563 pobj form,in
R1103 T1569 T1570 npadvmod site,unedited
R1104 T1570 T1565 amod unedited,form
R1105 T1568 T1567 punct /,R
R1106 T1572 T1573 npadvmod seizure,prone
R1107 T1571 T1570 punct -,unedited
R1108 T1574 T1573 punct -,prone
R1109 T1575 T1544 cc and,become
R1110 T1573 T1544 acomp prone,become
R1111 T1577 T1576 advmod prematurely,die
R1112 T1578 T1579 punct [,53
R1113 T1576 T1544 conj die,become
R1114 T1580 T1579 punct ],53
R1115 T1579 T1576 parataxis 53,die
R1116 T1583 T1584 nsubjpass Some,overcome
R1117 T1581 T1544 punct .,become
R1118 T1585 T1583 prep of,Some
R1119 T1586 T1587 det these,problems
R1120 T1588 T1584 aux can,overcome
R1121 T1589 T1584 auxpass be,overcome
R1122 T1587 T1585 pobj problems,of
R1123 T1591 T1584 prep by,overcome
R1124 T1590 T1584 advmod partially,overcome
R1125 T1593 T1592 prep of,use
R1126 T1594 T1595 advmod spatially,restricted
R1127 T1595 T1598 amod restricted,systems
R1128 T1592 T1591 pobj use,by
R1129 T1597 T1594 conj temporally,spatially
R1130 T1598 T1593 pobj systems,of
R1131 T1596 T1594 cc and,spatially
R1132 T1600 T1601 punct [,54
R1133 T1601 T1598 parataxis 54,systems
R1134 T1599 T1598 compound expression,systems
R1135 T1603 T1601 prep 56,54
R1136 T1604 T1601 punct ],54
R1137 T1602 T1603 punct –,56
R1138 T1606 T1607 prep in,system
R1139 T1605 T1598 punct ", ",systems
R1140 T1608 T1606 amod particular,in
R1141 T1609 T1607 det the,system
R1142 T1610 T1611 compound Cre,lox
R1143 T1607 T1598 appos system,systems
R1144 T1612 T1611 punct -,lox
R1145 T1613 T1584 punct ", ",overcome
R1146 T1611 T1607 compound lox,system
R1147 T1615 T1584 advcl marked,overcome
R1148 T1614 T1615 mark with,marked
R1149 T1617 T1619 compound recombinase,expression
R1150 T1618 T1617 punct -,recombinase
R1151 T1619 T1615 nsubj expression,marked
R1152 T1616 T1617 compound Cre,recombinase
R1153 T1621 T1622 amod defined,areas
R1154 T1620 T1619 prep in,expression
R1155 T1623 T1622 compound brain,areas
R1156 T1624 T1622 prep of,areas
R1157 T1622 T1620 pobj areas,in
R1158 T1626 T1628 amod targeted,mice
R1159 T1625 T1626 npadvmod gene,targeted
R1160 T1628 T1624 pobj mice,of
R1161 T1627 T1626 punct -,targeted
R1162 T1630 T1631 compound GluR,B
R1163 T1631 T1633 compound B,alleles
R1164 T1629 T1628 acl carrying,mice
R1165 T1633 T1629 dobj alleles,carrying
R1166 T1632 T1631 punct -,B
R1167 T1635 T1636 compound loxP,sites
R1168 T1636 T1634 pobj sites,by
R1169 T1634 T1615 agent by,marked
R1170 T1638 T1639 npadvmod Cre,mediated
R1171 T1637 T1636 prep for,sites
R1172 T1640 T1639 punct -,mediated
R1173 T1641 T1637 pobj recombination,for
R1174 T1639 T1641 amod mediated,recombination
R1175 T1643 T1584 parataxis 57,overcome
R1176 T1642 T1643 punct [,57
R1177 T1645 T1643 punct ],57
R1178 T1646 T1584 punct .,overcome
R1179 T1644 T1643 punct ",",57
R1180 T1648 T1649 advmod Indeed,resulted
R1181 T1650 T1649 punct ", ",resulted
R1182 T1652 T1653 det the,expression
R1183 T1653 T1651 dobj expression,restricting
R1184 T1651 T1649 csubj restricting,resulted
R1185 T1655 T1656 nmod Q,R
R1186 T1656 T1658 nmod R,B
R1187 T1654 T1653 prep of,expression
R1188 T1658 T1654 pobj B,of
R1189 T1657 T1656 punct /,R
R1190 T1660 T1658 amod unedited,B
R1191 T1659 T1660 npadvmod site,unedited
R1192 T1662 T1658 compound GluR,B
R1193 T1663 T1658 punct -,B
R1194 T1661 T1660 punct -,unedited
R1195 T1665 T1664 pobj forebrain,to
R1196 T1666 T1649 prep in,resulted
R1197 T1664 T1651 prep to,restricting
R1198 T1668 T1669 amod normal,lifespan
R1199 T1669 T1666 pobj lifespan,in
R1200 T1667 T1668 advmod almost,normal
R1201 T1671 T1672 det an,phenotype
R1202 T1672 T1669 conj phenotype,lifespan
R1203 T1670 T1669 cc and,lifespan
R1204 T1674 T1675 advmod weakly,prone
R1205 T1675 T1672 amod prone,phenotype
R1206 T1673 T1674 advmod only,weakly
R1207 T1677 T1675 punct -,prone
R1208 T1676 T1675 npadvmod seizure,prone
R1209 T1679 T1649 parataxis 58,resulted
R1210 T1678 T1679 punct [,58
R1211 T1681 T1649 punct .,resulted
R1212 T1680 T1679 punct ],58
R1213 T1683 T1684 nsubj Mice,appeared
R1214 T1685 T1683 prep with,Mice
R1215 T1686 T1687 npadvmod forebrain,specific
R1216 T1688 T1687 punct -,specific
R1217 T1689 T1685 pobj depletion,with
R1218 T1687 T1689 amod specific,depletion
R1219 T1690 T1691 compound GluR,B
R1220 T1692 T1691 punct -,B
R1221 T1693 T1694 advmod almost,completely
R1222 T1691 T1689 compound B,depletion
R1223 T1695 T1684 oprd normal,appeared
R1224 T1696 T1684 prep throughout,appeared
R1225 T1694 T1695 advmod completely,normal
R1226 T1698 T1684 prep with,appeared
R1227 T1699 T1700 det no,abnormalities
R1228 T1697 T1696 pobj life,throughout
R1229 T1701 T1700 amod developmental,abnormalities
R1230 T1702 T1684 punct ", ",appeared
R1231 T1700 T1698 pobj abnormalities,with
R1232 T1704 T1684 advcl permitting,appeared
R1233 T1703 T1704 advmod thus,permitting
R1234 T1706 T1704 dobj investigation,permitting
R1235 T1705 T1706 det a,investigation
R1236 T1708 T1706 punct ", ",investigation
R1237 T1709 T1706 amod quantitative,investigation
R1238 T1707 T1706 amod detailed,investigation
R1239 T1711 T1712 amod olfactory,behavior
R1240 T1712 T1710 pobj behavior,of
R1241 T1710 T1706 prep of,investigation
R1243 T1713 T1684 punct .,appeared
R766 T1218 T1643 nummod 55,57