Id |
Subject |
Object |
Predicate |
Lexical cue |
T6587 |
0-7 |
NN |
denotes |
Cadmium |
T6588 |
8-16 |
NN |
denotes |
response |
T6590 |
17-19 |
IN |
denotes |
of |
T6591 |
20-25 |
NN |
denotes |
Ndrg1 |
T6589 |
26-33 |
VBZ |
denotes |
depends |
T6592 |
34-36 |
IN |
denotes |
on |
T6593 |
37-40 |
NN |
denotes |
MTF |
T6594 |
40-41 |
HYPH |
denotes |
- |
T6595 |
41-42 |
CD |
denotes |
1 |
T6596 |
42-219 |
sentence |
denotes |
Ndrg1 was significantly downregulated in microarrays of liver transcripts from cadmium-treated Mtf1Mx-cre mice compared to similarly treated Mtf1loxP control mice (Table 1, c). |
T6597 |
43-48 |
NN |
denotes |
Ndrg1 |
T6599 |
49-52 |
VBD |
denotes |
was |
T6600 |
53-66 |
RB |
denotes |
significantly |
T6598 |
67-80 |
VBN |
denotes |
downregulated |
T6601 |
81-83 |
IN |
denotes |
in |
T6602 |
84-95 |
NNS |
denotes |
microarrays |
T6603 |
96-98 |
IN |
denotes |
of |
T6604 |
99-104 |
NN |
denotes |
liver |
T6605 |
105-116 |
NNS |
denotes |
transcripts |
T6606 |
117-121 |
IN |
denotes |
from |
T6607 |
122-129 |
NN |
denotes |
cadmium |
T6609 |
129-130 |
HYPH |
denotes |
- |
T6608 |
130-137 |
VBN |
denotes |
treated |
T6611 |
138-144 |
NN |
denotes |
Mtf1Mx |
T6613 |
144-145 |
HYPH |
denotes |
- |
T6612 |
145-148 |
NN |
denotes |
cre |
T6610 |
149-153 |
NNS |
denotes |
mice |
T6614 |
154-162 |
VBN |
denotes |
compared |
T6615 |
163-165 |
IN |
denotes |
to |
T6616 |
166-175 |
RB |
denotes |
similarly |
T6617 |
176-183 |
VBN |
denotes |
treated |
T6619 |
184-192 |
NN |
denotes |
Mtf1loxP |
T6620 |
193-200 |
NN |
denotes |
control |
T6618 |
201-205 |
NNS |
denotes |
mice |
T6621 |
206-207 |
-LRB- |
denotes |
( |
T6623 |
207-212 |
NN |
denotes |
Table |
T6624 |
213-214 |
CD |
denotes |
1 |
T6625 |
214-216 |
, |
denotes |
, |
T6622 |
216-217 |
NN |
denotes |
c |
T6626 |
217-218 |
-RRB- |
denotes |
) |
T6627 |
218-219 |
. |
denotes |
. |
T6628 |
219-401 |
sentence |
denotes |
Ndrg1 probably has some role in stress response since various stimuli, including hypoxia and nickel compounds, activate expression of rodent Ndrg1 and/or its human ortholog (37–40). |
T6629 |
220-225 |
NN |
denotes |
Ndrg1 |
T6631 |
226-234 |
RB |
denotes |
probably |
T6630 |
235-238 |
VBZ |
denotes |
has |
T6632 |
239-243 |
DT |
denotes |
some |
T6633 |
244-248 |
NN |
denotes |
role |
T6634 |
249-251 |
IN |
denotes |
in |
T6635 |
252-258 |
NN |
denotes |
stress |
T6636 |
259-267 |
NN |
denotes |
response |
T6637 |
268-273 |
IN |
denotes |
since |
T6639 |
274-281 |
JJ |
denotes |
various |
T6640 |
282-289 |
NNS |
denotes |
stimuli |
T6641 |
289-291 |
, |
denotes |
, |
T6642 |
291-300 |
VBG |
denotes |
including |
T6643 |
301-308 |
NN |
denotes |
hypoxia |
T6645 |
309-312 |
CC |
denotes |
and |
T6646 |
313-319 |
NN |
denotes |
nickel |
T6644 |
320-329 |
NNS |
denotes |
compounds |
T6647 |
329-331 |
, |
denotes |
, |
T6638 |
331-339 |
VBP |
denotes |
activate |
T6648 |
340-350 |
NN |
denotes |
expression |
T6649 |
351-353 |
IN |
denotes |
of |
T6650 |
354-360 |
NN |
denotes |
rodent |
T6651 |
361-366 |
NN |
denotes |
Ndrg1 |
T6652 |
367-370 |
CC |
denotes |
and |
T6653 |
370-371 |
HYPH |
denotes |
/ |
T6654 |
371-373 |
CC |
denotes |
or |
T6655 |
374-377 |
PRP$ |
denotes |
its |
T6657 |
378-383 |
JJ |
denotes |
human |
T6656 |
384-392 |
NN |
denotes |
ortholog |
T6658 |
393-394 |
-LRB- |
denotes |
( |
T6659 |
394-396 |
CD |
denotes |
37 |
T6660 |
396-397 |
SYM |
denotes |
– |
T6661 |
397-399 |
CD |
denotes |
40 |
T6662 |
399-400 |
-RRB- |
denotes |
) |
T6663 |
400-401 |
. |
denotes |
. |
T6664 |
401-713 |
sentence |
denotes |
The Ndrg1 microarray results were confirmed with semiquantitative RT–PCRs (Figure 3a): for Mtf1loxP control livers, a clear increase of Ndrg1 expression was observed after cadmium exposure; in livers from Mtf1Mx-cre mice, this cadmium response was not detectable, while basal expression was similar to controls. |
T6665 |
402-405 |
DT |
denotes |
The |
T6667 |
406-411 |
NN |
denotes |
Ndrg1 |
T6668 |
412-422 |
NN |
denotes |
microarray |
T6666 |
423-430 |
NNS |
denotes |
results |
T6670 |
431-435 |
VBD |
denotes |
were |
T6669 |
436-445 |
VBN |
denotes |
confirmed |
T6672 |
446-450 |
IN |
denotes |
with |
T6673 |
451-467 |
JJ |
denotes |
semiquantitative |
T6675 |
468-470 |
NN |
denotes |
RT |
T6676 |
470-471 |
HYPH |
denotes |
– |
T6674 |
471-475 |
NNS |
denotes |
PCRs |
T6677 |
476-477 |
-LRB- |
denotes |
( |
T6679 |
477-483 |
NN |
denotes |
Figure |
T6678 |
484-486 |
NN |
denotes |
3a |
T6680 |
486-487 |
-RRB- |
denotes |
) |
T6681 |
487-489 |
: |
denotes |
: |
T6682 |
489-492 |
IN |
denotes |
for |
T6684 |
493-501 |
NN |
denotes |
Mtf1loxP |
T6686 |
502-509 |
NN |
denotes |
control |
T6685 |
510-516 |
NNS |
denotes |
livers |
T6687 |
516-518 |
, |
denotes |
, |
T6688 |
518-519 |
DT |
denotes |
a |
T6690 |
520-525 |
JJ |
denotes |
clear |
T6689 |
526-534 |
NN |
denotes |
increase |
T6691 |
535-537 |
IN |
denotes |
of |
T6692 |
538-543 |
NN |
denotes |
Ndrg1 |
T6693 |
544-554 |
NN |
denotes |
expression |
T6694 |
555-558 |
VBD |
denotes |
was |
T6683 |
559-567 |
VBN |
denotes |
observed |
T6695 |
568-573 |
IN |
denotes |
after |
T6696 |
574-581 |
NN |
denotes |
cadmium |
T6697 |
582-590 |
NN |
denotes |
exposure |
T6698 |
590-591 |
: |
denotes |
; |
T6699 |
592-594 |
IN |
denotes |
in |
T6700 |
595-601 |
NNS |
denotes |
livers |
T6701 |
602-606 |
IN |
denotes |
from |
T6702 |
607-613 |
NN |
denotes |
Mtf1Mx |
T6704 |
613-614 |
HYPH |
denotes |
- |
T6703 |
614-617 |
NN |
denotes |
cre |
T6705 |
618-622 |
NNS |
denotes |
mice |
T6706 |
622-624 |
, |
denotes |
, |
T6707 |
624-628 |
DT |
denotes |
this |
T6709 |
629-636 |
NN |
denotes |
cadmium |
T6708 |
637-645 |
NN |
denotes |
response |
T6671 |
646-649 |
VBD |
denotes |
was |
T6710 |
650-653 |
RB |
denotes |
not |
T6711 |
654-664 |
JJ |
denotes |
detectable |
T6712 |
664-666 |
, |
denotes |
, |
T6713 |
666-671 |
IN |
denotes |
while |
T6715 |
672-677 |
JJ |
denotes |
basal |
T6716 |
678-688 |
NN |
denotes |
expression |
T6714 |
689-692 |
VBD |
denotes |
was |
T6717 |
693-700 |
JJ |
denotes |
similar |
T6718 |
701-703 |
IN |
denotes |
to |
T6719 |
704-712 |
NNS |
denotes |
controls |
T6720 |
712-713 |
. |
denotes |
. |
T6721 |
713-787 |
sentence |
denotes |
This indicates that cadmium-induced expression of Ndrg1 depends on MTF-1. |
T6722 |
714-718 |
DT |
denotes |
This |
T6723 |
719-728 |
VBZ |
denotes |
indicates |
T6724 |
729-733 |
IN |
denotes |
that |
T6726 |
734-741 |
NN |
denotes |
cadmium |
T6728 |
741-742 |
HYPH |
denotes |
- |
T6727 |
742-749 |
VBN |
denotes |
induced |
T6729 |
750-760 |
NN |
denotes |
expression |
T6730 |
761-763 |
IN |
denotes |
of |
T6731 |
764-769 |
NN |
denotes |
Ndrg1 |
T6725 |
770-777 |
VBZ |
denotes |
depends |
T6732 |
778-780 |
IN |
denotes |
on |
T6733 |
781-784 |
NN |
denotes |
MTF |
T6734 |
784-785 |
HYPH |
denotes |
- |
T6735 |
785-786 |
CD |
denotes |
1 |
T6736 |
786-787 |
. |
denotes |
. |
T6737 |
787-894 |
sentence |
denotes |
Five MRE core consensus sequences are located upstream of the mouse Ndrg1 transcription start (Figure 3b). |
T6738 |
788-792 |
CD |
denotes |
Five |
T6740 |
793-796 |
NN |
denotes |
MRE |
T6741 |
797-801 |
NN |
denotes |
core |
T6742 |
802-811 |
NN |
denotes |
consensus |
T6739 |
812-821 |
NNS |
denotes |
sequences |
T6744 |
822-825 |
VBP |
denotes |
are |
T6743 |
826-833 |
VBN |
denotes |
located |
T6745 |
834-842 |
RB |
denotes |
upstream |
T6746 |
843-845 |
IN |
denotes |
of |
T6747 |
846-849 |
DT |
denotes |
the |
T6749 |
850-855 |
NN |
denotes |
mouse |
T6750 |
856-861 |
NN |
denotes |
Ndrg1 |
T6751 |
862-875 |
NN |
denotes |
transcription |
T6748 |
876-881 |
NN |
denotes |
start |
T6752 |
882-883 |
-LRB- |
denotes |
( |
T6754 |
883-889 |
NN |
denotes |
Figure |
T6753 |
890-892 |
NN |
denotes |
3b |
T6755 |
892-893 |
-RRB- |
denotes |
) |
T6756 |
893-894 |
. |
denotes |
. |
T6757 |
894-1013 |
sentence |
denotes |
Four of them are clustered (MRE1 to MRE4, −138 to −332 bp), the fifth one is located farther upstream (MRE5, −883 bp). |
T6758 |
895-899 |
CD |
denotes |
Four |
T6760 |
900-902 |
IN |
denotes |
of |
T6761 |
903-907 |
PRP |
denotes |
them |
T6762 |
908-911 |
VBP |
denotes |
are |
T6759 |
912-921 |
VBN |
denotes |
clustered |
T6764 |
922-923 |
-LRB- |
denotes |
( |
T6766 |
923-927 |
NN |
denotes |
MRE1 |
T6767 |
928-930 |
IN |
denotes |
to |
T6768 |
931-935 |
NN |
denotes |
MRE4 |
T6769 |
935-937 |
, |
denotes |
, |
T6770 |
937-938 |
SYM |
denotes |
− |
T6772 |
938-941 |
CD |
denotes |
138 |
T6773 |
942-944 |
IN |
denotes |
to |
T6774 |
945-946 |
SYM |
denotes |
− |
T6771 |
946-949 |
CD |
denotes |
332 |
T6765 |
950-952 |
NN |
denotes |
bp |
T6775 |
952-953 |
-RRB- |
denotes |
) |
T6776 |
953-955 |
, |
denotes |
, |
T6777 |
955-958 |
DT |
denotes |
the |
T6779 |
959-964 |
JJ |
denotes |
fifth |
T6778 |
965-968 |
CD |
denotes |
one |
T6780 |
969-971 |
VBZ |
denotes |
is |
T6763 |
972-979 |
VBN |
denotes |
located |
T6781 |
980-987 |
RB |
denotes |
farther |
T6782 |
988-996 |
RB |
denotes |
upstream |
T6783 |
997-998 |
-LRB- |
denotes |
( |
T6785 |
998-1002 |
NN |
denotes |
MRE5 |
T6786 |
1002-1004 |
, |
denotes |
, |
T6787 |
1004-1005 |
SYM |
denotes |
− |
T6788 |
1005-1008 |
CD |
denotes |
883 |
T6784 |
1009-1011 |
NN |
denotes |
bp |
T6789 |
1011-1012 |
-RRB- |
denotes |
) |
T6790 |
1012-1013 |
. |
denotes |
. |
T6791 |
1013-1134 |
sentence |
denotes |
EMSA was performed to test whether MTF-1 is interacting with some or all of the four proximal MRE sequences (Figure 3c). |
T6792 |
1014-1018 |
NN |
denotes |
EMSA |
T6794 |
1019-1022 |
VBD |
denotes |
was |
T6793 |
1023-1032 |
VBN |
denotes |
performed |
T6795 |
1033-1035 |
TO |
denotes |
to |
T6796 |
1036-1040 |
VB |
denotes |
test |
T6797 |
1041-1048 |
IN |
denotes |
whether |
T6799 |
1049-1052 |
NN |
denotes |
MTF |
T6800 |
1052-1053 |
HYPH |
denotes |
- |
T6801 |
1053-1054 |
CD |
denotes |
1 |
T6802 |
1055-1057 |
VBZ |
denotes |
is |
T6798 |
1058-1069 |
VBG |
denotes |
interacting |
T6803 |
1070-1074 |
IN |
denotes |
with |
T6804 |
1075-1079 |
DT |
denotes |
some |
T6805 |
1080-1082 |
CC |
denotes |
or |
T6806 |
1083-1086 |
DT |
denotes |
all |
T6807 |
1087-1089 |
IN |
denotes |
of |
T6808 |
1090-1093 |
DT |
denotes |
the |
T6810 |
1094-1098 |
CD |
denotes |
four |
T6811 |
1099-1107 |
JJ |
denotes |
proximal |
T6812 |
1108-1111 |
NN |
denotes |
MRE |
T6809 |
1112-1121 |
NNS |
denotes |
sequences |
T6813 |
1122-1123 |
-LRB- |
denotes |
( |
T6815 |
1123-1129 |
NN |
denotes |
Figure |
T6814 |
1130-1132 |
NN |
denotes |
3c |
T6816 |
1132-1133 |
-RRB- |
denotes |
) |
T6817 |
1133-1134 |
. |
denotes |
. |
T6818 |
1134-1280 |
sentence |
denotes |
Separate oligonucleotides were tested for MRE1 and MRE2, whereas one oligonucleotide spanning both sequences was used for MRE3 and MRE4 (MRE3,4). |
T6819 |
1135-1143 |
JJ |
denotes |
Separate |
T6820 |
1144-1160 |
NNS |
denotes |
oligonucleotides |
T6822 |
1161-1165 |
VBD |
denotes |
were |
T6821 |
1166-1172 |
VBN |
denotes |
tested |
T6823 |
1173-1176 |
IN |
denotes |
for |
T6824 |
1177-1181 |
NN |
denotes |
MRE1 |
T6825 |
1182-1185 |
CC |
denotes |
and |
T6826 |
1186-1190 |
NN |
denotes |
MRE2 |
T6827 |
1190-1192 |
, |
denotes |
, |
T6828 |
1192-1199 |
IN |
denotes |
whereas |
T6830 |
1200-1203 |
CD |
denotes |
one |
T6831 |
1204-1219 |
NN |
denotes |
oligonucleotide |
T6832 |
1220-1228 |
VBG |
denotes |
spanning |
T6833 |
1229-1233 |
DT |
denotes |
both |
T6834 |
1234-1243 |
NNS |
denotes |
sequences |
T6835 |
1244-1247 |
VBD |
denotes |
was |
T6829 |
1248-1252 |
VBN |
denotes |
used |
T6836 |
1253-1256 |
IN |
denotes |
for |
T6837 |
1257-1261 |
NN |
denotes |
MRE3 |
T6838 |
1262-1265 |
CC |
denotes |
and |
T6839 |
1266-1270 |
NN |
denotes |
MRE4 |
T6840 |
1271-1272 |
-LRB- |
denotes |
( |
T6842 |
1272-1276 |
NN |
denotes |
MRE3 |
T6843 |
1276-1277 |
, |
denotes |
, |
T6841 |
1277-1278 |
CD |
denotes |
4 |
T6844 |
1278-1279 |
-RRB- |
denotes |
) |
T6845 |
1279-1280 |
. |
denotes |
. |
T6846 |
1280-1451 |
sentence |
denotes |
No complex was seen with MRE1, but specific MTF-1 complexes were observed for both the MRE2 and MRE3,4 oligonucleotides with liver protein extract from an Mtf1loxP mouse. |
T6847 |
1281-1283 |
DT |
denotes |
No |
T6848 |
1284-1291 |
NN |
denotes |
complex |
T6850 |
1292-1295 |
VBD |
denotes |
was |
T6849 |
1296-1300 |
VBN |
denotes |
seen |
T6851 |
1301-1305 |
IN |
denotes |
with |
T6852 |
1306-1310 |
NN |
denotes |
MRE1 |
T6853 |
1310-1312 |
, |
denotes |
, |
T6854 |
1312-1315 |
CC |
denotes |
but |
T6855 |
1316-1324 |
JJ |
denotes |
specific |
T6857 |
1325-1328 |
NN |
denotes |
MTF |
T6858 |
1328-1329 |
HYPH |
denotes |
- |
T6859 |
1329-1330 |
CD |
denotes |
1 |
T6856 |
1331-1340 |
NNS |
denotes |
complexes |
T6861 |
1341-1345 |
VBD |
denotes |
were |
T6860 |
1346-1354 |
VBN |
denotes |
observed |
T6862 |
1355-1358 |
IN |
denotes |
for |
T6863 |
1359-1363 |
CC |
denotes |
both |
T6865 |
1364-1367 |
DT |
denotes |
the |
T6864 |
1368-1372 |
NN |
denotes |
MRE2 |
T6866 |
1373-1376 |
CC |
denotes |
and |
T6867 |
1377-1381 |
NN |
denotes |
MRE3 |
T6868 |
1381-1382 |
, |
denotes |
, |
T6869 |
1382-1383 |
CD |
denotes |
4 |
T6870 |
1384-1400 |
NNS |
denotes |
oligonucleotides |
T6871 |
1401-1405 |
IN |
denotes |
with |
T6872 |
1406-1411 |
NN |
denotes |
liver |
T6874 |
1412-1419 |
NN |
denotes |
protein |
T6873 |
1420-1427 |
NN |
denotes |
extract |
T6875 |
1428-1432 |
IN |
denotes |
from |
T6876 |
1433-1435 |
DT |
denotes |
an |
T6878 |
1436-1444 |
NN |
denotes |
Mtf1loxP |
T6877 |
1445-1450 |
NN |
denotes |
mouse |
T6879 |
1450-1451 |
. |
denotes |
. |
T6880 |
1451-1552 |
sentence |
denotes |
As expected, no bandshift was observed with protein extract from a mouse lacking MTF-1 (Mtf1Mx-cre). |
T6881 |
1452-1454 |
IN |
denotes |
As |
T6882 |
1455-1463 |
VBN |
denotes |
expected |
T6884 |
1463-1465 |
, |
denotes |
, |
T6885 |
1465-1467 |
DT |
denotes |
no |
T6886 |
1468-1477 |
NN |
denotes |
bandshift |
T6887 |
1478-1481 |
VBD |
denotes |
was |
T6883 |
1482-1490 |
VBN |
denotes |
observed |
T6888 |
1491-1495 |
IN |
denotes |
with |
T6889 |
1496-1503 |
NN |
denotes |
protein |
T6890 |
1504-1511 |
NN |
denotes |
extract |
T6891 |
1512-1516 |
IN |
denotes |
from |
T6892 |
1517-1518 |
DT |
denotes |
a |
T6893 |
1519-1524 |
NN |
denotes |
mouse |
T6894 |
1525-1532 |
VBG |
denotes |
lacking |
T6895 |
1533-1536 |
NN |
denotes |
MTF |
T6896 |
1536-1537 |
HYPH |
denotes |
- |
T6897 |
1537-1538 |
CD |
denotes |
1 |
T6898 |
1539-1540 |
-LRB- |
denotes |
( |
T6899 |
1540-1546 |
NN |
denotes |
Mtf1Mx |
T6901 |
1546-1547 |
HYPH |
denotes |
- |
T6900 |
1547-1550 |
NN |
denotes |
cre |
T6902 |
1550-1551 |
-RRB- |
denotes |
) |
T6903 |
1551-1552 |
. |
denotes |
. |
R4203 |
T6587 |
T6588 |
compound |
Cadmium,response |
R4204 |
T6588 |
T6589 |
nsubj |
response,depends |
R4205 |
T6590 |
T6588 |
prep |
of,response |
R4206 |
T6591 |
T6590 |
pobj |
Ndrg1,of |
R4207 |
T6592 |
T6589 |
prep |
on,depends |
R4208 |
T6593 |
T6592 |
pobj |
MTF,on |
R4209 |
T6594 |
T6593 |
punct |
-,MTF |
R4210 |
T6595 |
T6593 |
nummod |
1,MTF |
R4211 |
T6597 |
T6598 |
nsubjpass |
Ndrg1,downregulated |
R4212 |
T6599 |
T6598 |
auxpass |
was,downregulated |
R4213 |
T6600 |
T6598 |
advmod |
significantly,downregulated |
R4214 |
T6601 |
T6598 |
prep |
in,downregulated |
R4215 |
T6602 |
T6601 |
pobj |
microarrays,in |
R4216 |
T6603 |
T6602 |
prep |
of,microarrays |
R4217 |
T6604 |
T6605 |
compound |
liver,transcripts |
R4218 |
T6605 |
T6603 |
pobj |
transcripts,of |
R4219 |
T6606 |
T6605 |
prep |
from,transcripts |
R4220 |
T6607 |
T6608 |
npadvmod |
cadmium,treated |
R4221 |
T6608 |
T6610 |
amod |
treated,mice |
R4222 |
T6609 |
T6608 |
punct |
-,treated |
R4223 |
T6610 |
T6606 |
pobj |
mice,from |
R4224 |
T6611 |
T6612 |
compound |
Mtf1Mx,cre |
R4225 |
T6612 |
T6610 |
compound |
cre,mice |
R4226 |
T6613 |
T6612 |
punct |
-,cre |
R4227 |
T6614 |
T6598 |
prep |
compared,downregulated |
R4228 |
T6615 |
T6614 |
prep |
to,compared |
R4229 |
T6616 |
T6617 |
advmod |
similarly,treated |
R4230 |
T6617 |
T6618 |
amod |
treated,mice |
R4231 |
T6618 |
T6615 |
pobj |
mice,to |
R4232 |
T6619 |
T6618 |
compound |
Mtf1loxP,mice |
R4233 |
T6620 |
T6618 |
compound |
control,mice |
R4234 |
T6621 |
T6622 |
punct |
(,c |
R4235 |
T6622 |
T6598 |
parataxis |
c,downregulated |
R4236 |
T6623 |
T6622 |
nmod |
Table,c |
R4237 |
T6624 |
T6622 |
nummod |
1,c |
R4238 |
T6625 |
T6622 |
punct |
", ",c |
R4239 |
T6626 |
T6622 |
punct |
),c |
R4240 |
T6627 |
T6598 |
punct |
.,downregulated |
R4241 |
T6629 |
T6630 |
nsubj |
Ndrg1,has |
R4242 |
T6631 |
T6630 |
advmod |
probably,has |
R4243 |
T6632 |
T6633 |
det |
some,role |
R4244 |
T6633 |
T6630 |
dobj |
role,has |
R4245 |
T6634 |
T6633 |
prep |
in,role |
R4246 |
T6635 |
T6636 |
compound |
stress,response |
R4247 |
T6636 |
T6634 |
pobj |
response,in |
R4248 |
T6637 |
T6638 |
mark |
since,activate |
R4249 |
T6638 |
T6630 |
advcl |
activate,has |
R4250 |
T6639 |
T6640 |
amod |
various,stimuli |
R4251 |
T6640 |
T6638 |
nsubj |
stimuli,activate |
R4252 |
T6641 |
T6640 |
punct |
", ",stimuli |
R4253 |
T6642 |
T6640 |
prep |
including,stimuli |
R4254 |
T6643 |
T6644 |
nmod |
hypoxia,compounds |
R4255 |
T6644 |
T6642 |
pobj |
compounds,including |
R4256 |
T6645 |
T6643 |
cc |
and,hypoxia |
R4257 |
T6646 |
T6643 |
conj |
nickel,hypoxia |
R4258 |
T6647 |
T6638 |
punct |
", ",activate |
R4259 |
T6648 |
T6638 |
dobj |
expression,activate |
R4260 |
T6649 |
T6648 |
prep |
of,expression |
R4261 |
T6650 |
T6651 |
compound |
rodent,Ndrg1 |
R4262 |
T6651 |
T6649 |
pobj |
Ndrg1,of |
R4263 |
T6652 |
T6648 |
cc |
and,expression |
R4264 |
T6653 |
T6652 |
punct |
/,and |
R4265 |
T6654 |
T6652 |
cc |
or,and |
R4266 |
T6655 |
T6656 |
poss |
its,ortholog |
R4267 |
T6656 |
T6648 |
conj |
ortholog,expression |
R4268 |
T6657 |
T6656 |
amod |
human,ortholog |
R4269 |
T6658 |
T6659 |
punct |
(,37 |
R4270 |
T6659 |
T6638 |
parataxis |
37,activate |
R4271 |
T6660 |
T6661 |
punct |
–,40 |
R4272 |
T6661 |
T6659 |
prep |
40,37 |
R4273 |
T6662 |
T6659 |
punct |
),37 |
R4274 |
T6663 |
T6630 |
punct |
.,has |
R4275 |
T6665 |
T6666 |
det |
The,results |
R4276 |
T6666 |
T6669 |
nsubjpass |
results,confirmed |
R4277 |
T6667 |
T6666 |
compound |
Ndrg1,results |
R4278 |
T6668 |
T6666 |
compound |
microarray,results |
R4279 |
T6669 |
T6671 |
ccomp |
confirmed,was |
R4280 |
T6670 |
T6669 |
auxpass |
were,confirmed |
R4281 |
T6672 |
T6669 |
prep |
with,confirmed |
R4282 |
T6673 |
T6674 |
amod |
semiquantitative,PCRs |
R4283 |
T6674 |
T6672 |
pobj |
PCRs,with |
R4284 |
T6675 |
T6674 |
compound |
RT,PCRs |
R4285 |
T6676 |
T6674 |
punct |
–,PCRs |
R4286 |
T6677 |
T6678 |
punct |
(,3a |
R4287 |
T6678 |
T6669 |
parataxis |
3a,confirmed |
R4288 |
T6679 |
T6678 |
compound |
Figure,3a |
R4289 |
T6680 |
T6678 |
punct |
),3a |
R4290 |
T6681 |
T6671 |
punct |
: ,was |
R4291 |
T6682 |
T6683 |
prep |
for,observed |
R4292 |
T6683 |
T6671 |
ccomp |
observed,was |
R4293 |
T6684 |
T6685 |
compound |
Mtf1loxP,livers |
R4294 |
T6685 |
T6682 |
pobj |
livers,for |
R4295 |
T6686 |
T6685 |
compound |
control,livers |
R4296 |
T6687 |
T6683 |
punct |
", ",observed |
R4297 |
T6688 |
T6689 |
det |
a,increase |
R4298 |
T6689 |
T6683 |
nsubjpass |
increase,observed |
R4299 |
T6690 |
T6689 |
amod |
clear,increase |
R4300 |
T6691 |
T6689 |
prep |
of,increase |
R4301 |
T6692 |
T6693 |
compound |
Ndrg1,expression |
R4302 |
T6693 |
T6691 |
pobj |
expression,of |
R4303 |
T6694 |
T6683 |
auxpass |
was,observed |
R4304 |
T6695 |
T6683 |
prep |
after,observed |
R4305 |
T6696 |
T6697 |
compound |
cadmium,exposure |
R4306 |
T6697 |
T6695 |
pobj |
exposure,after |
R4307 |
T6698 |
T6671 |
punct |
;,was |
R4308 |
T6699 |
T6671 |
prep |
in,was |
R4309 |
T6700 |
T6699 |
pobj |
livers,in |
R4310 |
T6701 |
T6700 |
prep |
from,livers |
R4311 |
T6702 |
T6703 |
compound |
Mtf1Mx,cre |
R4312 |
T6703 |
T6705 |
compound |
cre,mice |
R4313 |
T6704 |
T6703 |
punct |
-,cre |
R4314 |
T6705 |
T6701 |
pobj |
mice,from |
R4315 |
T6706 |
T6671 |
punct |
", ",was |
R4316 |
T6707 |
T6708 |
det |
this,response |
R4317 |
T6708 |
T6671 |
nsubj |
response,was |
R4318 |
T6709 |
T6708 |
compound |
cadmium,response |
R4319 |
T6710 |
T6671 |
neg |
not,was |
R4320 |
T6711 |
T6671 |
acomp |
detectable,was |
R4321 |
T6712 |
T6671 |
punct |
", ",was |
R4322 |
T6713 |
T6714 |
mark |
while,was |
R4323 |
T6714 |
T6671 |
advcl |
was,was |
R4324 |
T6715 |
T6716 |
amod |
basal,expression |
R4325 |
T6716 |
T6714 |
nsubj |
expression,was |
R4326 |
T6717 |
T6714 |
acomp |
similar,was |
R4327 |
T6718 |
T6717 |
prep |
to,similar |
R4328 |
T6719 |
T6718 |
pobj |
controls,to |
R4329 |
T6720 |
T6671 |
punct |
.,was |
R4330 |
T6722 |
T6723 |
nsubj |
This,indicates |
R4331 |
T6724 |
T6725 |
mark |
that,depends |
R4332 |
T6725 |
T6723 |
ccomp |
depends,indicates |
R4333 |
T6726 |
T6727 |
npadvmod |
cadmium,induced |
R4334 |
T6727 |
T6729 |
amod |
induced,expression |
R4335 |
T6728 |
T6727 |
punct |
-,induced |
R4336 |
T6729 |
T6725 |
nsubj |
expression,depends |
R4337 |
T6730 |
T6729 |
prep |
of,expression |
R4338 |
T6731 |
T6730 |
pobj |
Ndrg1,of |
R4339 |
T6732 |
T6725 |
prep |
on,depends |
R4340 |
T6733 |
T6732 |
pobj |
MTF,on |
R4341 |
T6734 |
T6733 |
punct |
-,MTF |
R4342 |
T6735 |
T6733 |
nummod |
1,MTF |
R4343 |
T6736 |
T6723 |
punct |
.,indicates |
R4344 |
T6738 |
T6739 |
nummod |
Five,sequences |
R4345 |
T6739 |
T6743 |
nsubjpass |
sequences,located |
R4346 |
T6740 |
T6739 |
compound |
MRE,sequences |
R4347 |
T6741 |
T6739 |
compound |
core,sequences |
R4348 |
T6742 |
T6739 |
compound |
consensus,sequences |
R4349 |
T6744 |
T6743 |
auxpass |
are,located |
R4350 |
T6745 |
T6743 |
advmod |
upstream,located |
R4351 |
T6746 |
T6745 |
prep |
of,upstream |
R4352 |
T6747 |
T6748 |
det |
the,start |
R4353 |
T6748 |
T6746 |
pobj |
start,of |
R4354 |
T6749 |
T6748 |
compound |
mouse,start |
R4355 |
T6750 |
T6748 |
compound |
Ndrg1,start |
R4356 |
T6751 |
T6748 |
compound |
transcription,start |
R4357 |
T6752 |
T6753 |
punct |
(,3b |
R4358 |
T6753 |
T6743 |
parataxis |
3b,located |
R4359 |
T6754 |
T6753 |
compound |
Figure,3b |
R4360 |
T6755 |
T6753 |
punct |
),3b |
R4361 |
T6756 |
T6743 |
punct |
.,located |
R4362 |
T6758 |
T6759 |
nsubjpass |
Four,clustered |
R4363 |
T6759 |
T6763 |
ccomp |
clustered,located |
R4364 |
T6760 |
T6758 |
prep |
of,Four |
R4365 |
T6761 |
T6760 |
pobj |
them,of |
R4366 |
T6762 |
T6759 |
auxpass |
are,clustered |
R4367 |
T6764 |
T6765 |
punct |
(,bp |
R4368 |
T6765 |
T6759 |
parataxis |
bp,clustered |
R4369 |
T6766 |
T6765 |
dep |
MRE1,bp |
R4370 |
T6767 |
T6766 |
prep |
to,MRE1 |
R4371 |
T6768 |
T6767 |
pobj |
MRE4,to |
R4372 |
T6769 |
T6765 |
punct |
", ",bp |
R4373 |
T6770 |
T6771 |
punct |
−,332 |
R4374 |
T6771 |
T6765 |
nummod |
332,bp |
R4375 |
T6772 |
T6771 |
quantmod |
138,332 |
R4376 |
T6773 |
T6771 |
quantmod |
to,332 |
R4377 |
T6774 |
T6771 |
punct |
−,332 |
R4378 |
T6775 |
T6765 |
punct |
),bp |
R4379 |
T6776 |
T6763 |
punct |
", ",located |
R4380 |
T6777 |
T6778 |
det |
the,one |
R4381 |
T6778 |
T6763 |
nsubjpass |
one,located |
R4382 |
T6779 |
T6778 |
amod |
fifth,one |
R4383 |
T6780 |
T6763 |
auxpass |
is,located |
R4384 |
T6781 |
T6782 |
advmod |
farther,upstream |
R4385 |
T6782 |
T6763 |
advmod |
upstream,located |
R4386 |
T6783 |
T6784 |
punct |
(,bp |
R4387 |
T6784 |
T6763 |
parataxis |
bp,located |
R4388 |
T6785 |
T6784 |
dep |
MRE5,bp |
R4389 |
T6786 |
T6784 |
punct |
", ",bp |
R4390 |
T6787 |
T6788 |
punct |
−,883 |
R4391 |
T6788 |
T6784 |
nummod |
883,bp |
R4392 |
T6789 |
T6784 |
punct |
),bp |
R4393 |
T6790 |
T6763 |
punct |
.,located |
R4394 |
T6792 |
T6793 |
nsubjpass |
EMSA,performed |
R4395 |
T6794 |
T6793 |
auxpass |
was,performed |
R4396 |
T6795 |
T6796 |
aux |
to,test |
R4397 |
T6796 |
T6793 |
advcl |
test,performed |
R4398 |
T6797 |
T6798 |
mark |
whether,interacting |
R4399 |
T6798 |
T6796 |
ccomp |
interacting,test |
R4400 |
T6799 |
T6798 |
nsubj |
MTF,interacting |
R4401 |
T6800 |
T6799 |
punct |
-,MTF |
R4402 |
T6801 |
T6799 |
nummod |
1,MTF |
R4403 |
T6802 |
T6798 |
aux |
is,interacting |
R4404 |
T6803 |
T6798 |
prep |
with,interacting |
R4405 |
T6804 |
T6803 |
pobj |
some,with |
R4406 |
T6805 |
T6804 |
cc |
or,some |
R4407 |
T6806 |
T6804 |
conj |
all,some |
R4408 |
T6807 |
T6806 |
prep |
of,all |
R4409 |
T6808 |
T6809 |
det |
the,sequences |
R4410 |
T6809 |
T6807 |
pobj |
sequences,of |
R4411 |
T6810 |
T6809 |
nummod |
four,sequences |
R4412 |
T6811 |
T6809 |
amod |
proximal,sequences |
R4413 |
T6812 |
T6809 |
compound |
MRE,sequences |
R4414 |
T6813 |
T6814 |
punct |
(,3c |
R4415 |
T6814 |
T6798 |
parataxis |
3c,interacting |
R4416 |
T6815 |
T6814 |
compound |
Figure,3c |
R4417 |
T6816 |
T6814 |
punct |
),3c |
R4418 |
T6817 |
T6793 |
punct |
.,performed |
R4419 |
T6819 |
T6820 |
amod |
Separate,oligonucleotides |
R4420 |
T6820 |
T6821 |
nsubjpass |
oligonucleotides,tested |
R4421 |
T6822 |
T6821 |
auxpass |
were,tested |
R4422 |
T6823 |
T6821 |
prep |
for,tested |
R4423 |
T6824 |
T6823 |
pobj |
MRE1,for |
R4424 |
T6825 |
T6824 |
cc |
and,MRE1 |
R4425 |
T6826 |
T6824 |
conj |
MRE2,MRE1 |
R4426 |
T6827 |
T6821 |
punct |
", ",tested |
R4427 |
T6828 |
T6829 |
mark |
whereas,used |
R4428 |
T6829 |
T6821 |
advcl |
used,tested |
R4429 |
T6830 |
T6831 |
nummod |
one,oligonucleotide |
R4430 |
T6831 |
T6829 |
nsubjpass |
oligonucleotide,used |
R4431 |
T6832 |
T6831 |
acl |
spanning,oligonucleotide |
R4432 |
T6833 |
T6834 |
det |
both,sequences |
R4433 |
T6834 |
T6832 |
dobj |
sequences,spanning |
R4434 |
T6835 |
T6829 |
auxpass |
was,used |
R4435 |
T6836 |
T6829 |
prep |
for,used |
R4436 |
T6837 |
T6836 |
pobj |
MRE3,for |
R4437 |
T6838 |
T6837 |
cc |
and,MRE3 |
R4438 |
T6839 |
T6837 |
conj |
MRE4,MRE3 |
R4439 |
T6840 |
T6841 |
punct |
(,4 |
R4440 |
T6841 |
T6829 |
parataxis |
4,used |
R4441 |
T6842 |
T6841 |
dep |
MRE3,4 |
R4442 |
T6843 |
T6841 |
punct |
",",4 |
R4443 |
T6844 |
T6841 |
punct |
),4 |
R4444 |
T6845 |
T6821 |
punct |
.,tested |
R4445 |
T6847 |
T6848 |
det |
No,complex |
R4446 |
T6848 |
T6849 |
nsubjpass |
complex,seen |
R4447 |
T6850 |
T6849 |
auxpass |
was,seen |
R4448 |
T6851 |
T6849 |
prep |
with,seen |
R4449 |
T6852 |
T6851 |
pobj |
MRE1,with |
R4450 |
T6853 |
T6849 |
punct |
", ",seen |
R4451 |
T6854 |
T6849 |
cc |
but,seen |
R4452 |
T6855 |
T6856 |
amod |
specific,complexes |
R4453 |
T6856 |
T6860 |
nsubjpass |
complexes,observed |
R4454 |
T6857 |
T6856 |
nmod |
MTF,complexes |
R4455 |
T6858 |
T6857 |
punct |
-,MTF |
R4456 |
T6859 |
T6857 |
nummod |
1,MTF |
R4457 |
T6860 |
T6849 |
conj |
observed,seen |
R4458 |
T6861 |
T6860 |
auxpass |
were,observed |
R4459 |
T6862 |
T6860 |
prep |
for,observed |
R4460 |
T6863 |
T6864 |
preconj |
both,MRE2 |
R4461 |
T6864 |
T6862 |
pobj |
MRE2,for |
R4462 |
T6865 |
T6864 |
det |
the,MRE2 |
R4463 |
T6866 |
T6864 |
cc |
and,MRE2 |
R4464 |
T6867 |
T6864 |
conj |
MRE3,MRE2 |
R4465 |
T6868 |
T6864 |
punct |
",",MRE2 |
R4466 |
T6869 |
T6870 |
nummod |
4,oligonucleotides |
R4467 |
T6870 |
T6864 |
appos |
oligonucleotides,MRE2 |
R4468 |
T6871 |
T6870 |
prep |
with,oligonucleotides |
R4469 |
T6872 |
T6873 |
compound |
liver,extract |
R4470 |
T6873 |
T6871 |
pobj |
extract,with |
R4471 |
T6874 |
T6873 |
compound |
protein,extract |
R4472 |
T6875 |
T6873 |
prep |
from,extract |
R4473 |
T6876 |
T6877 |
det |
an,mouse |
R4474 |
T6877 |
T6875 |
pobj |
mouse,from |
R4475 |
T6878 |
T6877 |
compound |
Mtf1loxP,mouse |
R4476 |
T6879 |
T6860 |
punct |
.,observed |
R4477 |
T6881 |
T6882 |
mark |
As,expected |
R4478 |
T6882 |
T6883 |
advcl |
expected,observed |
R4479 |
T6884 |
T6883 |
punct |
", ",observed |
R4480 |
T6885 |
T6886 |
det |
no,bandshift |
R4481 |
T6886 |
T6883 |
nsubjpass |
bandshift,observed |
R4482 |
T6887 |
T6883 |
auxpass |
was,observed |
R4483 |
T6888 |
T6883 |
prep |
with,observed |
R4484 |
T6889 |
T6890 |
compound |
protein,extract |
R4485 |
T6890 |
T6888 |
pobj |
extract,with |
R4486 |
T6891 |
T6890 |
prep |
from,extract |
R4487 |
T6892 |
T6893 |
det |
a,mouse |
R4488 |
T6893 |
T6891 |
pobj |
mouse,from |
R4489 |
T6894 |
T6893 |
acl |
lacking,mouse |
R4490 |
T6895 |
T6894 |
dobj |
MTF,lacking |
R4491 |
T6896 |
T6895 |
punct |
-,MTF |
R4492 |
T6897 |
T6895 |
nummod |
1,MTF |
R4493 |
T6898 |
T6893 |
punct |
(,mouse |
R4494 |
T6899 |
T6900 |
compound |
Mtf1Mx,cre |
R4495 |
T6900 |
T6893 |
appos |
cre,mouse |
R4496 |
T6901 |
T6900 |
punct |
-,cre |
R4497 |
T6902 |
T6883 |
punct |
),observed |
R4498 |
T6903 |
T6883 |
punct |
.,observed |