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PMC:1253828 / 15963-17027 JSONTXT 4 Projects

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Id Subject Object Predicate Lexical cue
T4869 0-3 IN denotes For
T4871 4-13 NN denotes induction
T4872 14-16 IN denotes of
T4873 17-20 NN denotes Cre
T4874 21-32 NN denotes recombinase
T4875 32-34 , denotes ,
T4876 34-38 NN denotes Mtf1
T4878 39-50 JJ denotes conditional
T4879 51-59 NN denotes knockout
T4877 60-64 NNS denotes mice
T4880 65-74 VBG denotes harboring
T4881 75-78 DT denotes the
T4883 79-81 NN denotes Mx
T4885 81-82 HYPH denotes -
T4884 82-85 NN denotes cre
T4882 86-95 NN denotes transgene
T4886 96-97 -LRB- denotes (
T4887 97-103 NN denotes Mtf1Mx
T4889 103-104 HYPH denotes -
T4888 104-107 NN denotes cre
T4890 107-108 -RRB- denotes )
T4870 109-117 VBD denotes received
T4892 118-122 CD denotes four
T4894 123-138 JJ denotes intraperitoneal
T4895 139-141 NN denotes pI
T4897 141-142 HYPH denotes –
T4896 142-144 NN denotes pC
T4893 145-155 NNS denotes injections
T4898 156-158 IN denotes at
T4899 159-160 CD denotes 3
T4900 161-164 NN denotes day
T4901 165-174 NNS denotes intervals
T4902 175-176 -LRB- denotes (
T4904 176-178 NN denotes pI
T4906 178-179 HYPH denotes –
T4905 179-181 NN denotes pC
T4903 182-191 NN denotes induction
T4907 191-192 -RRB- denotes )
T4908 192-193 : denotes ;
T4909 194-201 NN denotes control
T4910 202-213 NNS denotes littermates
T4911 214-221 IN denotes without
T4912 222-231 NN denotes transgene
T4913 232-233 -LRB- denotes (
T4914 233-241 NN denotes Mtf1loxP
T4915 241-242 -RRB- denotes )
T4891 243-251 VBD denotes received
T4916 252-259 JJ denotes similar
T4917 260-270 NNS denotes injections
T4918 270-271 . denotes .
T4919 271-440 sentence denotes Using RT–PCRs (Figure 1b), a shortened product was obtained with RNA from Mtf1Mx-cre livers, indicating a successful excision of exons 3 and 4 of Mtf1 in these animals.
T4920 272-277 VBG denotes Using
T4922 278-280 NN denotes RT
T4924 280-281 HYPH denotes –
T4923 281-285 NNS denotes PCRs
T4925 286-287 -LRB- denotes (
T4927 287-293 NN denotes Figure
T4926 294-296 NN denotes 1b
T4928 296-297 -RRB- denotes )
T4929 297-299 , denotes ,
T4930 299-300 DT denotes a
T4932 301-310 VBN denotes shortened
T4931 311-318 NN denotes product
T4933 319-322 VBD denotes was
T4921 323-331 VBN denotes obtained
T4934 332-336 IN denotes with
T4935 337-340 NN denotes RNA
T4936 341-345 IN denotes from
T4937 346-352 NN denotes Mtf1Mx
T4939 352-353 HYPH denotes -
T4938 353-356 NN denotes cre
T4940 357-363 NNS denotes livers
T4941 363-365 , denotes ,
T4942 365-375 VBG denotes indicating
T4943 376-377 DT denotes a
T4945 378-388 JJ denotes successful
T4944 389-397 NN denotes excision
T4946 398-400 IN denotes of
T4947 401-406 NNS denotes exons
T4948 407-408 CD denotes 3
T4949 409-412 CC denotes and
T4950 413-414 CD denotes 4
T4951 415-417 IN denotes of
T4952 418-422 NN denotes Mtf1
T4953 423-425 IN denotes in
T4954 426-431 DT denotes these
T4955 432-439 NNS denotes animals
T4956 439-440 . denotes .
T4957 440-615 sentence denotes On close examination, a very faint band similar in size to full-length signal was also observed in those mice, probably due to a low amount of residual full-length Mtf1 mRNA.
T4958 441-443 IN denotes On
T4960 444-449 JJ denotes close
T4961 450-461 NN denotes examination
T4962 461-463 , denotes ,
T4963 463-464 DT denotes a
T4965 465-469 RB denotes very
T4966 470-475 JJ denotes faint
T4964 476-480 NN denotes band
T4967 481-488 JJ denotes similar
T4968 489-491 IN denotes in
T4969 492-496 NN denotes size
T4970 497-499 IN denotes to
T4971 500-504 JJ denotes full
T4973 504-505 HYPH denotes -
T4972 505-511 NN denotes length
T4974 512-518 NN denotes signal
T4975 519-522 VBD denotes was
T4976 523-527 RB denotes also
T4959 528-536 VBN denotes observed
T4977 537-539 IN denotes in
T4978 540-545 DT denotes those
T4979 546-550 NNS denotes mice
T4980 550-552 , denotes ,
T4981 552-560 RB denotes probably
T4982 561-564 IN denotes due
T4983 565-567 IN denotes to
T4984 568-569 DT denotes a
T4986 570-573 JJ denotes low
T4985 574-580 NN denotes amount
T4987 581-583 IN denotes of
T4988 584-592 JJ denotes residual
T4990 593-597 JJ denotes full
T4992 597-598 HYPH denotes -
T4991 598-604 NN denotes length
T4993 605-609 NN denotes Mtf1
T4989 610-614 NN denotes mRNA
T4994 614-615 . denotes .
T4995 615-865 sentence denotes The level of functional MTF-1 protein was examined by EMSA (Figure 1c): MTF-1 protein–DNA complex was detectable with liver protein extract from an Mtf1loxP control mouse, but no functional MRE-binding protein was observed with an Mtf1Mx-cre sample.
T4996 616-619 DT denotes The
T4997 620-625 NN denotes level
T4999 626-628 IN denotes of
T5000 629-639 JJ denotes functional
T5002 640-643 NN denotes MTF
T5003 643-644 HYPH denotes -
T5004 644-645 CD denotes 1
T5001 646-653 NN denotes protein
T5005 654-657 VBD denotes was
T4998 658-666 VBN denotes examined
T5007 667-669 IN denotes by
T5008 670-674 NN denotes EMSA
T5009 675-676 -LRB- denotes (
T5011 676-682 NN denotes Figure
T5010 683-685 NN denotes 1c
T5012 685-686 -RRB- denotes )
T5013 686-688 : denotes :
T5014 688-691 NN denotes MTF
T5016 691-692 HYPH denotes -
T5017 692-693 CD denotes 1
T5018 694-701 NN denotes protein
T5019 701-702 HYPH denotes –
T5020 702-705 NN denotes DNA
T5015 706-713 NN denotes complex
T5006 714-717 VBD denotes was
T5021 718-728 JJ denotes detectable
T5022 729-733 IN denotes with
T5023 734-739 NN denotes liver
T5025 740-747 NN denotes protein
T5024 748-755 NN denotes extract
T5026 756-760 IN denotes from
T5027 761-763 DT denotes an
T5029 764-772 NN denotes Mtf1loxP
T5030 773-780 NN denotes control
T5028 781-786 NN denotes mouse
T5031 786-788 , denotes ,
T5032 788-791 CC denotes but
T5033 792-794 DT denotes no
T5035 795-805 JJ denotes functional
T5036 806-809 NN denotes MRE
T5038 809-810 HYPH denotes -
T5037 810-817 VBG denotes binding
T5034 818-825 NN denotes protein
T5040 826-829 VBD denotes was
T5039 830-838 VBN denotes observed
T5041 839-843 IN denotes with
T5042 844-846 DT denotes an
T5044 847-853 NN denotes Mtf1Mx
T5046 853-854 HYPH denotes -
T5045 854-857 NN denotes cre
T5043 858-864 NN denotes sample
T5047 864-865 . denotes .
T5048 865-961 sentence denotes Thus, deletion of exons 3 and 4 of Mtf1 in the liver of Mtf1Mx-cre mice was virtually complete.
T5049 866-870 RB denotes Thus
T5051 870-872 , denotes ,
T5052 872-880 NN denotes deletion
T5053 881-883 IN denotes of
T5054 884-889 NNS denotes exons
T5055 890-891 CD denotes 3
T5056 892-895 CC denotes and
T5057 896-897 CD denotes 4
T5058 898-900 IN denotes of
T5059 901-905 NN denotes Mtf1
T5060 906-908 IN denotes in
T5061 909-912 DT denotes the
T5062 913-918 NN denotes liver
T5063 919-921 IN denotes of
T5064 922-928 NN denotes Mtf1Mx
T5066 928-929 HYPH denotes -
T5065 929-932 NN denotes cre
T5067 933-937 NNS denotes mice
T5050 938-941 VBD denotes was
T5068 942-951 RB denotes virtually
T5069 952-960 JJ denotes complete
T5070 960-961 . denotes .
T5071 961-1064 sentence denotes All examined liver-specific knockout mice were viable under laboratory conditions and appeared normal.
T5072 962-965 DT denotes All
T5074 966-974 VBN denotes examined
T5075 975-980 NN denotes liver
T5077 980-981 HYPH denotes -
T5076 981-989 JJ denotes specific
T5078 990-998 NN denotes knockout
T5073 999-1003 NNS denotes mice
T5079 1004-1008 VBD denotes were
T5080 1009-1015 JJ denotes viable
T5081 1016-1021 IN denotes under
T5082 1022-1032 NN denotes laboratory
T5083 1033-1043 NNS denotes conditions
T5084 1044-1047 CC denotes and
T5085 1048-1056 VBD denotes appeared
T5086 1057-1063 JJ denotes normal
T5087 1063-1064 . denotes .
R3117 T4869 T4870 prep For,received
R3118 T4870 T4891 ccomp received,received
R3119 T4871 T4869 pobj induction,For
R3120 T4872 T4871 prep of,induction
R3121 T4873 T4874 compound Cre,recombinase
R3122 T4874 T4872 pobj recombinase,of
R3123 T4875 T4870 punct ", ",received
R3124 T4876 T4877 nmod Mtf1,mice
R3125 T4877 T4870 nsubj mice,received
R3126 T4878 T4879 amod conditional,knockout
R3127 T4879 T4877 compound knockout,mice
R3128 T4880 T4877 acl harboring,mice
R3129 T4881 T4882 det the,transgene
R3130 T4882 T4880 dobj transgene,harboring
R3131 T4883 T4884 compound Mx,cre
R3132 T4884 T4882 compound cre,transgene
R3133 T4885 T4884 punct -,cre
R3134 T4886 T4882 punct (,transgene
R3135 T4887 T4888 compound Mtf1Mx,cre
R3136 T4888 T4882 appos cre,transgene
R3137 T4889 T4888 punct -,cre
R3138 T4890 T4870 punct ),received
R3139 T4892 T4893 nummod four,injections
R3140 T4893 T4870 dobj injections,received
R3141 T4894 T4893 amod intraperitoneal,injections
R3142 T4895 T4896 compound pI,pC
R3143 T4896 T4893 compound pC,injections
R3144 T4897 T4896 punct –,pC
R3145 T4898 T4870 prep at,received
R3146 T4899 T4900 nummod 3,day
R3147 T4900 T4901 compound day,intervals
R3148 T4901 T4898 pobj intervals,at
R3149 T4902 T4903 punct (,induction
R3150 T4903 T4870 parataxis induction,received
R3151 T4904 T4905 compound pI,pC
R3152 T4905 T4903 compound pC,induction
R3153 T4906 T4905 punct –,pC
R3154 T4907 T4903 punct ),induction
R3155 T4908 T4891 punct ;,received
R3156 T4909 T4910 compound control,littermates
R3157 T4910 T4891 nsubj littermates,received
R3158 T4911 T4910 prep without,littermates
R3159 T4912 T4911 pobj transgene,without
R3160 T4913 T4912 punct (,transgene
R3161 T4914 T4912 appos Mtf1loxP,transgene
R3162 T4915 T4891 punct ),received
R3163 T4916 T4917 amod similar,injections
R3164 T4917 T4891 dobj injections,received
R3165 T4918 T4891 punct .,received
R3166 T4920 T4921 advcl Using,obtained
R3167 T4922 T4923 compound RT,PCRs
R3168 T4923 T4920 dobj PCRs,Using
R3169 T4924 T4923 punct –,PCRs
R3170 T4925 T4926 punct (,1b
R3171 T4926 T4920 parataxis 1b,Using
R3172 T4927 T4926 compound Figure,1b
R3173 T4928 T4926 punct ),1b
R3174 T4929 T4921 punct ", ",obtained
R3175 T4930 T4931 det a,product
R3176 T4931 T4921 nsubjpass product,obtained
R3177 T4932 T4931 amod shortened,product
R3178 T4933 T4921 auxpass was,obtained
R3179 T4934 T4921 prep with,obtained
R3180 T4935 T4934 pobj RNA,with
R3181 T4936 T4935 prep from,RNA
R3182 T4937 T4938 compound Mtf1Mx,cre
R3183 T4938 T4940 compound cre,livers
R3184 T4939 T4938 punct -,cre
R3185 T4940 T4936 pobj livers,from
R3186 T4941 T4921 punct ", ",obtained
R3187 T4942 T4921 advcl indicating,obtained
R3188 T4943 T4944 det a,excision
R3189 T4944 T4942 dobj excision,indicating
R3190 T4945 T4944 amod successful,excision
R3191 T4946 T4944 prep of,excision
R3192 T4947 T4948 nmod exons,3
R3193 T4948 T4946 pobj 3,of
R3194 T4949 T4948 cc and,3
R3195 T4950 T4948 conj 4,3
R3196 T4951 T4948 prep of,3
R3197 T4952 T4951 pobj Mtf1,of
R3198 T4953 T4942 prep in,indicating
R3199 T4954 T4955 det these,animals
R3200 T4955 T4953 pobj animals,in
R3201 T4956 T4921 punct .,obtained
R3202 T4958 T4959 prep On,observed
R3203 T4960 T4961 amod close,examination
R3204 T4961 T4958 pobj examination,On
R3205 T4962 T4959 punct ", ",observed
R3206 T4963 T4964 det a,band
R3207 T4964 T4959 nsubjpass band,observed
R3208 T4965 T4966 advmod very,faint
R3209 T4966 T4964 amod faint,band
R3210 T4967 T4964 relcl similar,band
R3211 T4968 T4967 prep in,similar
R3212 T4969 T4968 pobj size,in
R3213 T4970 T4967 prep to,similar
R3214 T4971 T4972 amod full,length
R3215 T4972 T4974 compound length,signal
R3216 T4973 T4972 punct -,length
R3217 T4974 T4970 pobj signal,to
R3218 T4975 T4959 auxpass was,observed
R3219 T4976 T4959 advmod also,observed
R3220 T4977 T4959 prep in,observed
R3221 T4978 T4979 det those,mice
R3222 T4979 T4977 pobj mice,in
R3223 T4980 T4959 punct ", ",observed
R3224 T4981 T4982 advmod probably,due
R3225 T4982 T4959 prep due,observed
R3226 T4983 T4982 pcomp to,due
R3227 T4984 T4985 det a,amount
R3228 T4985 T4982 pobj amount,due
R3229 T4986 T4985 amod low,amount
R3230 T4987 T4985 prep of,amount
R3231 T4988 T4989 amod residual,mRNA
R3232 T4989 T4987 pobj mRNA,of
R3233 T4990 T4991 amod full,length
R3234 T4991 T4989 compound length,mRNA
R3235 T4992 T4991 punct -,length
R3236 T4993 T4989 compound Mtf1,mRNA
R3237 T4994 T4959 punct .,observed
R3238 T4996 T4997 det The,level
R3239 T4997 T4998 nsubjpass level,examined
R3240 T4998 T5006 ccomp examined,was
R3241 T4999 T4997 prep of,level
R3242 T5000 T5001 amod functional,protein
R3243 T5001 T4999 pobj protein,of
R3244 T5002 T5001 nmod MTF,protein
R3245 T5003 T5002 punct -,MTF
R3246 T5004 T5002 nummod 1,MTF
R3247 T5005 T4998 auxpass was,examined
R3248 T5007 T4998 prep by,examined
R3249 T5008 T5007 pobj EMSA,by
R3250 T5009 T5010 punct (,1c
R3251 T5010 T4998 parataxis 1c,examined
R3252 T5011 T5010 compound Figure,1c
R3253 T5012 T5010 punct ),1c
R3254 T5013 T5006 punct : ,was
R3255 T5014 T5015 nmod MTF,complex
R3256 T5015 T5006 nsubj complex,was
R3257 T5016 T5014 punct -,MTF
R3258 T5017 T5014 nummod 1,MTF
R3259 T5018 T5015 compound protein,complex
R3260 T5019 T5015 punct –,complex
R3261 T5020 T5015 compound DNA,complex
R3262 T5021 T5006 acomp detectable,was
R3263 T5022 T5021 prep with,detectable
R3264 T5023 T5024 compound liver,extract
R3265 T5024 T5022 pobj extract,with
R3266 T5025 T5024 compound protein,extract
R3267 T5026 T5024 prep from,extract
R3268 T5027 T5028 det an,mouse
R3269 T5028 T5026 pobj mouse,from
R3270 T5029 T5028 compound Mtf1loxP,mouse
R3271 T5030 T5028 compound control,mouse
R3272 T5031 T5006 punct ", ",was
R3273 T5032 T5006 cc but,was
R3274 T5033 T5034 det no,protein
R3275 T5034 T5039 nsubjpass protein,observed
R3276 T5035 T5034 amod functional,protein
R3277 T5036 T5037 npadvmod MRE,binding
R3278 T5037 T5034 amod binding,protein
R3279 T5038 T5037 punct -,binding
R3280 T5039 T5006 conj observed,was
R3281 T5040 T5039 auxpass was,observed
R3282 T5041 T5039 prep with,observed
R3283 T5042 T5043 det an,sample
R3284 T5043 T5041 pobj sample,with
R3285 T5044 T5045 compound Mtf1Mx,cre
R3286 T5045 T5043 compound cre,sample
R3287 T5046 T5045 punct -,cre
R3288 T5047 T5006 punct .,was
R3289 T5049 T5050 advmod Thus,was
R3290 T5051 T5050 punct ", ",was
R3291 T5052 T5050 nsubj deletion,was
R3292 T5053 T5052 prep of,deletion
R3293 T5054 T5055 nmod exons,3
R3294 T5055 T5053 pobj 3,of
R3295 T5056 T5055 cc and,3
R3296 T5057 T5055 conj 4,3
R3297 T5058 T5055 prep of,3
R3298 T5059 T5058 pobj Mtf1,of
R3299 T5060 T5052 prep in,deletion
R3300 T5061 T5062 det the,liver
R3301 T5062 T5060 pobj liver,in
R3302 T5063 T5062 prep of,liver
R3303 T5064 T5065 compound Mtf1Mx,cre
R3304 T5065 T5067 compound cre,mice
R3305 T5066 T5065 punct -,cre
R3306 T5067 T5063 pobj mice,of
R3307 T5068 T5069 advmod virtually,complete
R3308 T5069 T5050 acomp complete,was
R3309 T5070 T5050 punct .,was
R3310 T5072 T5073 det All,mice
R3311 T5073 T5079 nsubj mice,were
R3312 T5074 T5073 amod examined,mice
R3313 T5075 T5076 npadvmod liver,specific
R3314 T5076 T5073 amod specific,mice
R3315 T5077 T5076 punct -,specific
R3316 T5078 T5073 compound knockout,mice
R3317 T5080 T5079 acomp viable,were
R3318 T5081 T5079 prep under,were
R3319 T5082 T5083 compound laboratory,conditions
R3320 T5083 T5081 pobj conditions,under
R3321 T5084 T5079 cc and,were
R3322 T5085 T5079 conj appeared,were
R3323 T5086 T5085 oprd normal,appeared
R3324 T5087 T5079 punct .,were