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PMC:1064854 / 49747-50586 JSONTXT 6 Projects

Annnotations TAB TSV DIC JSON TextAE

Id Subject Object Predicate Lexical cue
T31656 0-2 PRP denotes We
T31658 3-6 VBD denotes did
T31659 7-10 RB denotes not
T31657 11-15 VB denotes find
T31660 16-24 NN denotes evidence
T31661 25-28 IN denotes for
T31662 29-36 NN denotes glucose
T31663 37-48 NN denotes intolerance
T31664 49-51 CC denotes or
T31665 52-59 NN denotes insulin
T31666 60-70 NN denotes resistance
T31667 71-73 IN denotes in
T31668 74-77 DT denotes the
T31670 78-81 NN denotes PGC
T31672 81-82 HYPH denotes -
T31671 82-84 NN denotes 1α
T31673 84-85 SYM denotes −
T31674 85-86 HYPH denotes /
T31675 86-87 SYM denotes −
T31669 88-95 NNS denotes animals
T31676 96-98 IN denotes on
T31677 99-107 JJ denotes standard
T31678 108-112 NN denotes chow
T31679 112-113 . denotes .
T31680 113-250 sentence denotes Moreover, female PGC-1α−/− mice were more glucose-tolerant and insulin-sensitive than PGC-1α+/+ controls when consuming a high-fat diet.
T31681 114-122 RB denotes Moreover
T31683 122-124 , denotes ,
T31684 124-130 JJ denotes female
T31686 131-134 NN denotes PGC
T31688 134-135 HYPH denotes -
T31687 135-137 NN denotes 1α
T31689 137-138 SYM denotes −
T31690 138-139 HYPH denotes /
T31691 139-140 SYM denotes −
T31685 141-145 NNS denotes mice
T31682 146-150 VBD denotes were
T31692 151-155 RBR denotes more
T31694 156-163 NN denotes glucose
T31695 163-164 HYPH denotes -
T31693 164-172 JJ denotes tolerant
T31696 173-176 CC denotes and
T31697 177-184 NN denotes insulin
T31699 184-185 HYPH denotes -
T31698 185-194 JJ denotes sensitive
T31700 195-199 IN denotes than
T31701 200-203 NN denotes PGC
T31703 203-204 HYPH denotes -
T31702 204-206 NN denotes 1α
T31705 206-207 SYM denotes +
T31706 207-208 HYPH denotes /
T31707 208-209 SYM denotes +
T31704 210-218 NNS denotes controls
T31708 219-223 WRB denotes when
T31709 224-233 VBG denotes consuming
T31710 234-235 DT denotes a
T31712 236-240 JJ denotes high
T31714 240-241 HYPH denotes -
T31713 241-244 NN denotes fat
T31711 245-249 NN denotes diet
T31715 249-250 . denotes .
T31716 250-411 sentence denotes These findings are surprising, given the results of several recent studies demonstrating reduced expression of PGC-1α in human diabetic skeletal muscle [24,34].
T31717 251-256 DT denotes These
T31718 257-265 NNS denotes findings
T31719 266-269 VBP denotes are
T31720 270-280 JJ denotes surprising
T31721 280-282 , denotes ,
T31722 282-287 VBN denotes given
T31723 288-291 DT denotes the
T31724 292-299 NNS denotes results
T31725 300-302 IN denotes of
T31726 303-310 JJ denotes several
T31728 311-317 JJ denotes recent
T31727 318-325 NNS denotes studies
T31729 326-339 VBG denotes demonstrating
T31730 340-347 VBN denotes reduced
T31731 348-358 NN denotes expression
T31732 359-361 IN denotes of
T31733 362-365 NN denotes PGC
T31735 365-366 HYPH denotes -
T31734 366-368 NN denotes 1α
T31736 369-371 IN denotes in
T31737 372-377 JJ denotes human
T31739 378-386 JJ denotes diabetic
T31740 387-395 JJ denotes skeletal
T31738 396-402 NN denotes muscle
T31741 403-404 -LRB- denotes [
T31743 404-406 CD denotes 24
T31744 406-407 , denotes ,
T31742 407-409 CD denotes 34
T31745 409-410 -RRB- denotes ]
T31746 410-411 . denotes .
T31747 411-569 sentence denotes It is certainly possible that compensatory metabolic regulatory mechanisms have been activated in the PGC-1α-deficient mice, accounting for this observation.
T31748 412-414 PRP denotes It
T31749 415-417 VBZ denotes is
T31750 418-427 RB denotes certainly
T31751 428-436 JJ denotes possible
T31752 437-441 IN denotes that
T31754 442-454 JJ denotes compensatory
T31756 455-464 JJ denotes metabolic
T31757 465-475 JJ denotes regulatory
T31755 476-486 NNS denotes mechanisms
T31758 487-491 VBP denotes have
T31759 492-496 VBN denotes been
T31753 497-506 VBN denotes activated
T31760 507-509 IN denotes in
T31761 510-513 DT denotes the
T31763 514-517 NN denotes PGC
T31765 517-518 HYPH denotes -
T31764 518-520 NN denotes 1α
T31767 520-521 HYPH denotes -
T31766 521-530 JJ denotes deficient
T31762 531-535 NNS denotes mice
T31768 535-537 , denotes ,
T31769 537-547 VBG denotes accounting
T31770 548-551 IN denotes for
T31771 552-556 DT denotes this
T31772 557-568 NN denotes observation
T31773 568-569 . denotes .
T31774 569-677 sentence denotes Alternatively, PGC-1α could serve as a coactivator of factors that mediate diet-induced insulin resistance.
T31775 570-583 RB denotes Alternatively
T31777 583-585 , denotes ,
T31778 585-588 NN denotes PGC
T31780 588-589 HYPH denotes -
T31779 589-591 NN denotes 1α
T31781 592-597 MD denotes could
T31776 598-603 VB denotes serve
T31782 604-606 IN denotes as
T31783 607-608 DT denotes a
T31784 609-620 NN denotes coactivator
T31785 621-623 IN denotes of
T31786 624-631 NNS denotes factors
T31787 632-636 WDT denotes that
T31788 637-644 VBP denotes mediate
T31789 645-649 NN denotes diet
T31791 649-650 HYPH denotes -
T31790 650-657 VBN denotes induced
T31793 658-665 NN denotes insulin
T31792 666-676 NN denotes resistance
T31794 676-677 . denotes .
T31795 677-839 sentence denotes Consistent with this notion, we and others have shown that mice lacking the PGC-1α target PPAR exhibit resistance to diet-induced glucose intolerance [21,35,36].
T31796 678-688 JJ denotes Consistent
T31798 689-693 IN denotes with
T31799 694-698 DT denotes this
T31800 699-705 NN denotes notion
T31801 705-707 , denotes ,
T31802 707-709 PRP denotes we
T31803 710-713 CC denotes and
T31804 714-720 NNS denotes others
T31805 721-725 VBP denotes have
T31797 726-731 VBN denotes shown
T31806 732-736 IN denotes that
T31808 737-741 NNS denotes mice
T31809 742-749 VBG denotes lacking
T31810 750-753 DT denotes the
T31812 754-757 NN denotes PGC
T31814 757-758 HYPH denotes -
T31813 758-760 NN denotes 1α
T31811 761-767 NN denotes target
T31815 768-772 NN denotes PPAR
T31807 773-780 VBP denotes exhibit
T31816 781-791 NN denotes resistance
T31817 792-794 IN denotes to
T31818 795-799 NN denotes diet
T31820 799-800 HYPH denotes -
T31819 800-807 VBN denotes induced
T31822 808-815 NN denotes glucose
T31821 816-827 NN denotes intolerance
T31823 828-829 -LRB- denotes [
T31825 829-831 CD denotes 21
T31826 831-832 , denotes ,
T31827 832-834 CD denotes 35
T31828 834-835 , denotes ,
T31824 835-837 CD denotes 36
T31829 837-838 -RRB- denotes ]
T31830 838-839 . denotes .
R7134 T31656 T31657 nsubj We,find
R7137 T31658 T31657 aux did,find
R7141 T31659 T31657 neg not,find
R7145 T31660 T31657 dobj evidence,find
R7147 T31661 T31660 prep for,evidence
R7148 T31662 T31663 compound glucose,intolerance
R7151 T31663 T31661 pobj intolerance,for
R7154 T31664 T31663 cc or,intolerance
R7158 T31665 T31666 compound insulin,resistance
R7162 T31666 T31663 conj resistance,intolerance
R7165 T31667 T31657 prep in,find
R7172 T31668 T31669 det the,animals
R7176 T31669 T31667 pobj animals,in
R7179 T31670 T31671 nmod PGC,1α
R7182 T31671 T31669 nmod 1α,animals
R7184 T31672 T31671 punct -,1α
R7188 T31673 T31671 punct −,1α
R7192 T31674 T31671 punct /,1α
R7195 T31675 T31671 punct −,1α
R7199 T31676 T31669 prep on,animals
R7203 T31677 T31678 amod standard,chow
R7207 T31678 T31676 pobj chow,on
R7210 T31679 T31657 punct .,find
R7212 T31681 T31682 advmod Moreover,were
R7216 T31683 T31682 punct ", ",were
R7223 T31684 T31685 amod female,mice
R7227 T31685 T31682 nsubj mice,were
R7230 T31686 T31687 nmod PGC,1α
R7233 T31687 T31685 nmod 1α,mice
R7235 T31688 T31687 punct -,1α
R7239 T31689 T31687 punct −,1α
R7243 T31690 T31687 punct /,1α
R7247 T31691 T31687 punct −,1α
R7250 T31692 T31693 advmod more,tolerant
R7253 T31693 T31682 acomp tolerant,were
R7257 T31694 T31693 npadvmod glucose,tolerant
R7260 T31695 T31693 punct -,tolerant
R7261 T31696 T31693 cc and,tolerant
R7262 T31697 T31698 npadvmod insulin,sensitive
R7263 T31698 T31693 conj sensitive,tolerant
R7264 T31756 T31757 amod metabolic,regulatory
R7265 T31699 T31698 punct -,sensitive
R7266 T31757 T31755 amod regulatory,mechanisms
R7267 T31758 T31753 aux have,activated
R7268 T31700 T31693 prep than,tolerant
R7269 T31759 T31753 auxpass been,activated
R7270 T31760 T31753 prep in,activated
R7271 T31761 T31762 det the,mice
R7272 T31762 T31760 pobj mice,in
R7273 T31763 T31764 compound PGC,1α
R7274 T31701 T31702 nmod PGC,1α
R7275 T31764 T31766 npadvmod 1α,deficient
R7276 T31765 T31764 punct -,1α
R7277 T31766 T31762 amod deficient,mice
R7278 T31702 T31704 nmod 1α,controls
R7279 T31767 T31766 punct -,deficient
R7280 T31768 T31753 punct ", ",activated
R7281 T31769 T31753 advcl accounting,activated
R7282 T31703 T31702 punct -,1α
R7283 T31770 T31769 prep for,accounting
R7284 T31771 T31772 det this,observation
R7285 T31704 T31700 pobj controls,than
R7286 T31772 T31770 pobj observation,for
R7287 T31773 T31749 punct .,is
R7288 T31705 T31702 punct +,1α
R7289 T31775 T31776 advmod Alternatively,serve
R7290 T31706 T31702 punct /,1α
R7291 T31777 T31776 punct ", ",serve
R7292 T31778 T31779 compound PGC,1α
R7293 T31779 T31776 nsubj 1α,serve
R7294 T31707 T31702 punct +,1α
R7295 T31780 T31779 punct -,1α
R7296 T31781 T31776 aux could,serve
R7297 T31708 T31709 advmod when,consuming
R7298 T31782 T31776 prep as,serve
R7299 T31783 T31784 det a,coactivator
R7300 T31784 T31782 pobj coactivator,as
R7301 T31709 T31682 advcl consuming,were
R7302 T31785 T31784 prep of,coactivator
R7303 T31786 T31785 pobj factors,of
R7304 T31710 T31711 det a,diet
R7305 T31787 T31788 dep that,mediate
R7306 T31788 T31786 relcl mediate,factors
R7307 T31711 T31709 dobj diet,consuming
R7308 T31789 T31790 npadvmod diet,induced
R7309 T31790 T31792 amod induced,resistance
R7310 T31791 T31790 punct -,induced
R7311 T31712 T31713 amod high,fat
R7312 T31792 T31788 dobj resistance,mediate
R7313 T31793 T31792 compound insulin,resistance
R7314 T31713 T31711 compound fat,diet
R7315 T31794 T31776 punct .,serve
R7316 T31796 T31797 advcl Consistent,shown
R7317 T31714 T31713 punct -,fat
R7318 T31798 T31796 prep with,Consistent
R7319 T31799 T31800 det this,notion
R7320 T31715 T31682 punct .,were
R7321 T31800 T31798 pobj notion,with
R7322 T31801 T31797 punct ", ",shown
R7323 T31802 T31797 nsubj we,shown
R7324 T31803 T31802 cc and,we
R7325 T31804 T31802 conj others,we
R7326 T31717 T31718 det These,findings
R7327 T31805 T31797 aux have,shown
R7328 T31806 T31807 mark that,exhibit
R7329 T31718 T31719 nsubj findings,are
R7330 T31807 T31797 ccomp exhibit,shown
R7331 T31720 T31719 acomp surprising,are
R7332 T31808 T31807 nsubj mice,exhibit
R7333 T31809 T31808 acl lacking,mice
R7334 T31810 T31811 det the,target
R7335 T31811 T31809 dobj target,lacking
R7336 T31721 T31719 punct ", ",are
R7337 T31812 T31813 compound PGC,1α
R7338 T31813 T31811 compound 1α,target
R7339 T31814 T31813 punct -,1α
R7340 T31722 T31719 prep given,are
R7341 T31815 T31811 appos PPAR,target
R7342 T31816 T31807 dobj resistance,exhibit
R7343 T31723 T31724 det the,results
R7344 T31817 T31816 prep to,resistance
R7345 T31818 T31819 npadvmod diet,induced
R7346 T31819 T31821 amod induced,intolerance
R7347 T31724 T31722 pobj results,given
R7348 T31820 T31819 punct -,induced
R7349 T31821 T31817 pobj intolerance,to
R7350 T31725 T31724 prep of,results
R7351 T31822 T31821 compound glucose,intolerance
R7352 T31823 T31824 punct [,36
R7353 T31824 T31797 parataxis 36,shown
R7354 T31726 T31727 amod several,studies
R7355 T31825 T31824 nummod 21,36
R7356 T31826 T31824 punct ",",36
R7357 T31827 T31824 nummod 35,36
R7358 T31727 T31725 pobj studies,of
R7359 T31828 T31824 punct ",",36
R7360 T31829 T31824 punct ],36
R7361 T31728 T31727 amod recent,studies
R7362 T31830 T31797 punct .,shown
R7364 T31729 T31727 acl demonstrating,studies
R7367 T31730 T31731 amod reduced,expression
R7371 T31731 T31729 dobj expression,demonstrating
R7377 T31732 T31731 prep of,expression
R7381 T31733 T31734 compound PGC,1α
R7385 T31734 T31732 pobj 1α,of
R7388 T31735 T31734 punct -,1α
R7390 T31736 T31729 prep in,demonstrating
R7394 T31737 T31738 amod human,muscle
R7398 T31738 T31736 pobj muscle,in
R7400 T31739 T31738 amod diabetic,muscle
R7401 T31740 T31738 amod skeletal,muscle
R7403 T31741 T31742 punct [,34
R7406 T31742 T31719 parataxis 34,are
R7410 T31743 T31742 nummod 24,34
R7413 T31744 T31742 punct ",",34
R7417 T31745 T31742 punct ],34
R7420 T31746 T31719 punct .,are
R7424 T31748 T31749 nsubj It,is
R7431 T31750 T31749 advmod certainly,is
R7436 T31751 T31749 acomp possible,is
R7440 T31752 T31753 mark that,activated
R7442 T31753 T31749 ccomp activated,is
R7444 T31754 T31755 amod compensatory,mechanisms
R7447 T31755 T31753 nsubjpass mechanisms,activated