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PMC:3586680 / 16274-17662 JSONTXT 24 Projects

Annnotations TAB TSV DIC JSON TextAE

Id Subject Object Predicate Lexical cue
T9267 0-7 VBN denotes Altered
T9268 8-12 NNP denotes WWOX
T9269 13-23 NN denotes expression
T9270 24-26 VBZ denotes is
T9271 27-32 VBN denotes shown
T9272 33-35 IN denotes in
T9273 36-40 NNS denotes GBMs
T9274 40-41 , denotes ,
T9275 42-44 IN denotes in
T9276 45-50 WDT denotes which
T9277 51-65 NN denotes downregulation
T9278 66-68 IN denotes of
T9279 69-73 NNP denotes WWOX
T9280 74-76 VBZ denotes is
T9281 77-87 VBN denotes associated
T9282 88-92 IN denotes with
T9283 93-97 NN denotes loss
T9284 98-100 IN denotes of
T9285 101-115 NN denotes heterozygosity
T9286 116-119 CC denotes and
T9287 120-128 NN denotes promoter
T9288 129-140 NN denotes methylation
T9289 141-142 -LRB- denotes (
T9290 142-147 NNP denotes Kosla
T9291 148-150 FW denotes et
T9292 151-154 FW denotes al.
T9293 154-155 , denotes ,
T9294 156-160 CD denotes 2011
T9295 160-161 -RRB- denotes )
T9296 161-162 . denotes .
T9297 163-171 RB denotes Recently
T9298 171-172 , denotes ,
T9299 173-175 PRP denotes we
T9300 176-188 VBD denotes demonstrated
T9301 189-193 IN denotes that
T9302 194-207 VBN denotes overexpressed
T9303 208-212 NNP denotes WWOX
T9304 213-220 VBZ denotes induces
T9305 221-230 NN denotes apoptosis
T9306 231-233 IN denotes of
T9307 234-246 NN denotes glioblastoma
T9308 247-254 NN denotes U373-MG
T9309 255-260 NNS denotes cells
T9310 261-270 VBG denotes harboring
T9311 271-277 JJ denotes mutant
T9312 278-281 NN denotes p53
T9313 282-284 IN denotes by
T9314 285-292 VBG denotes causing
T9315 293-303 JJ denotes hypoploidy
T9316 304-307 CC denotes and
T9317 308-311 NNP denotes DNA
T9318 312-325 NN denotes fragmentation
T9319 326-327 -LRB- denotes (
T9320 327-333 NNP denotes Chiang
T9321 334-336 FW denotes et
T9322 337-340 FW denotes al.
T9323 340-341 , denotes ,
T9324 342-346 CD denotes 2012
T9325 346-347 -RRB- denotes )
T9326 347-348 . denotes .
T9327 349-356 RB denotes However
T9328 356-357 , denotes ,
T9329 358-365 JJ denotes ectopic
T9330 366-370 NNP denotes WWOX
T9331 371-374 VBZ denotes has
T9332 375-377 DT denotes no
T9333 378-384 NN denotes effect
T9334 385-389 IN denotes with
T9335 390-396 JJ denotes U87-MG
T9336 397-407 VBG denotes expressing
T9337 408-412 JJ denotes wild
T9338 413-417 NN denotes type
T9339 418-421 NN denotes p53
T9340 421-422 . denotes .
T9341 423-429 IN denotes Unlike
T9342 430-433 NNP denotes TMZ
T9343 433-434 , denotes ,
T9344 435-439 NNP denotes WWOX
T9345 440-447 VBZ denotes induces
T9346 448-457 NN denotes apoptosis
T9347 458-460 IN denotes of
T9348 461-468 NN denotes U373-MG
T9349 469-474 NNS denotes cells
T9350 475-478 IN denotes via
T9351 479-480 DT denotes a
T9352 481-505 JJ denotes mitochondria-independent
T9353 506-509 CC denotes and
T9354 510-531 JJ denotes caspase-3-independent
T9355 532-539 NN denotes pathway
T9356 540-541 -LRB- denotes (
T9357 541-547 NNP denotes Chiang
T9358 548-550 FW denotes et
T9359 551-554 FW denotes al.
T9360 554-555 , denotes ,
T9361 556-560 CD denotes 2012
T9362 560-561 -RRB- denotes )
T9363 561-562 . denotes .
T9364 563-568 IN denotes While
T9365 569-572 DT denotes the
T9366 573-583 VBG denotes underlying
T9367 584-594 NNS denotes mechanisms
T9368 595-598 VBP denotes are
T9369 599-606 JJ denotes unknown
T9370 606-607 , denotes ,
T9371 608-610 PRP denotes it
T9372 611-613 VBZ denotes is
T9373 614-624 JJ denotes reasonable
T9374 625-627 TO denotes to
T9375 628-634 VB denotes assume
T9376 635-639 IN denotes that
T9377 640-643 DT denotes the
T9378 644-652 NN denotes survival
T9379 653-655 IN denotes of
T9380 656-661 JJ denotes human
T9381 662-674 NN denotes glioblastoma
T9382 675-680 NNS denotes cells
T9383 681-688 VBZ denotes depends
T9384 689-693 IN denotes upon
T9385 694-706 NNS denotes interactions
T9386 707-714 IN denotes between
T9387 715-718 DT denotes the
T9388 719-735 NN denotes gain-of-function
T9389 736-738 IN denotes of
T9390 739-742 NN denotes p53
T9391 743-750 NNS denotes mutants
T9392 751-754 CC denotes and
T9393 755-759 NNP denotes WWOX
T9394 759-760 . denotes .
T9395 761-770 VBN denotes Activated
T9396 771-775 NNP denotes WWOX
T9397 776-781 VBZ denotes binds
T9398 782-786 JJ denotes wild
T9399 787-791 NN denotes type
T9400 792-795 NN denotes p53
T9401 796-800 IN denotes with
T9402 801-806 NNP denotes Ser46
T9403 807-822 NN denotes phosphorylation
T9404 823-824 -LRB- denotes (
T9405 824-829 NNP denotes Chang
T9406 830-832 FW denotes et
T9407 833-836 FW denotes al.
T9408 836-837 , denotes ,
T9409 838-843 JJ denotes 2005b
T9410 843-844 -RRB- denotes )
T9411 844-845 . denotes .
T9412 846-848 NNP denotes UV
T9413 849-860 NN denotes irradiation
T9414 861-869 VBZ denotes enhances
T9415 870-873 DT denotes the
T9416 874-881 JJ denotes binding
T9417 882-894 NNS denotes interactions
T9418 894-895 . denotes .
T9419 896-903 IN denotes Despite
T9420 904-907 DT denotes the
T9421 908-916 NN denotes presence
T9422 917-919 IN denotes of
T9423 920-925 NNP denotes Ser46
T9424 926-928 IN denotes in
T9425 929-935 NNP denotes Δ40p53
T9426 935-936 , denotes ,
T9427 937-944 JJ denotes binding
T9428 945-947 IN denotes of
T9429 948-952 DT denotes this
T9430 953-960 NN denotes protein
T9431 961-965 IN denotes with
T9432 966-970 NNP denotes WWOX
T9433 971-978 VBZ denotes remains
T9434 979-981 TO denotes to
T9435 982-984 VB denotes be
T9436 985-995 VBN denotes determined
T9437 995-996 . denotes .
T9438 997-999 PRP denotes We
T9439 1000-1009 VBP denotes postulate
T9440 1010-1014 IN denotes that
T9441 1015-1017 IN denotes in
T9442 1018-1021 NNP denotes GBM
T9443 1022-1027 NNS denotes cells
T9444 1027-1028 , denotes ,
T9445 1029-1033 DT denotes both
T9446 1034-1038 JJ denotes wild
T9447 1039-1043 NN denotes type
T9448 1044-1047 NN denotes p53
T9449 1048-1051 CC denotes and
T9450 1052-1059 JJ denotes ectopic
T9451 1060-1064 NNP denotes WWOX
T9452 1065-1073 NNS denotes proteins
T9453 1074-1080 VBP denotes appear
T9454 1081-1083 TO denotes to
T9455 1084-1088 VB denotes have
T9456 1089-1090 DT denotes a
T9457 1091-1101 JJ denotes functional
T9458 1102-1112 NN denotes antagonism
T9459 1112-1113 , denotes ,
T9460 1114-1121 RB denotes thereby
T9461 1122-1132 VBG denotes nullifying
T9462 1133-1137 DT denotes each
T9463 1138-1143 JJ denotes other
T9464 1146-1154 NN denotes function
T9465 1155-1157 IN denotes in
T9466 1158-1166 VBG denotes inducing
T9467 1167-1176 NN denotes apoptosis
T9468 1177-1178 -LRB- denotes (
T9469 1178-1184 NN denotes Figure
T9470 1185-1186 CD denotes 2
T9471 1186-1187 -RRB- denotes )
T9472 1187-1188 . denotes .
T9473 1189-1195 JJ denotes Mutant
T9474 1196-1199 NN denotes p53
T9475 1200-1208 NNS denotes proteins
T9476 1209-1212 MD denotes can
T9477 1212-1215 RB denotes not
T9478 1216-1220 NN denotes bind
T9479 1221-1228 JJ denotes ectopic
T9480 1229-1233 NNP denotes WWOX
T9481 1234-1236 IN denotes in
T9482 1237-1240 NNP denotes GBM
T9483 1241-1246 NNS denotes cells
T9484 1246-1247 , denotes ,
T9485 1248-1251 CC denotes and
T9486 1252-1256 NNP denotes WWOX
T9487 1257-1259 VBZ denotes is
T9488 1260-1264 JJ denotes able
T9489 1265-1267 TO denotes to
T9490 1268-1274 VB denotes induce
T9491 1275-1284 NN denotes apoptosis
T9492 1284-1285 . denotes .
T9493 1286-1293 IN denotes Whether
T9494 1294-1298 NNP denotes WWOX
T9495 1299-1305 VBZ denotes causes
T9496 1306-1315 NN denotes apoptosis
T9497 1316-1318 IN denotes in
T9498 1319-1322 NNP denotes GBM
T9499 1323-1333 VBG denotes expressing
T9500 1334-1337 NN denotes p53
T9501 1338-1346 NNS denotes isoforms
T9502 1347-1349 VBZ denotes is
T9503 1350-1357 JJ denotes unknown
T9504 1358-1361 CC denotes and
T9505 1362-1369 VBZ denotes remains
T9506 1370-1372 TO denotes to
T9507 1373-1375 VB denotes be
T9508 1376-1387 VBN denotes established
T9509 1387-1388 . denotes .
R6325 T9267 T9269 amod Altered,expression
R6326 T9268 T9269 compound WWOX,expression
R6327 T9269 T9271 nsubjpass expression,shown
R6328 T9270 T9271 auxpass is,shown
R6329 T9271 T9271 ROOT shown,shown
R6330 T9272 T9271 prep in,shown
R6331 T9273 T9272 pobj GBMs,in
R6332 T9274 T9273 punct ",",GBMs
R6333 T9275 T9281 prep in,associated
R6334 T9276 T9275 pobj which,in
R6335 T9277 T9281 nsubjpass downregulation,associated
R6336 T9278 T9277 prep of,downregulation
R6337 T9279 T9278 pobj WWOX,of
R6338 T9280 T9281 auxpass is,associated
R6339 T9281 T9271 conj associated,shown
R6340 T9282 T9281 prep with,associated
R6341 T9283 T9282 pobj loss,with
R6342 T9284 T9283 prep of,loss
R6343 T9285 T9284 pobj heterozygosity,of
R6344 T9286 T9285 cc and,heterozygosity
R6345 T9287 T9288 compound promoter,methylation
R6346 T9288 T9285 conj methylation,heterozygosity
R6347 T9289 T9292 punct (,al.
R6348 T9290 T9292 compound Kosla,al.
R6349 T9291 T9292 nmod et,al.
R6350 T9292 T9283 appos al.,loss
R6351 T9293 T9292 punct ",",al.
R6352 T9294 T9292 npadvmod 2011,al.
R6353 T9295 T9281 punct ),associated
R6354 T9296 T9271 punct .,shown
R6355 T9297 T9300 advmod Recently,demonstrated
R6356 T9298 T9300 punct ",",demonstrated
R6357 T9299 T9300 nsubj we,demonstrated
R6358 T9300 T9300 ROOT demonstrated,demonstrated
R6359 T9301 T9304 mark that,induces
R6360 T9302 T9303 compound overexpressed,WWOX
R6361 T9303 T9304 nsubj WWOX,induces
R6362 T9304 T9300 ccomp induces,demonstrated
R6363 T9305 T9304 dobj apoptosis,induces
R6364 T9306 T9305 prep of,apoptosis
R6365 T9307 T9309 amod glioblastoma,cells
R6366 T9308 T9309 compound U373-MG,cells
R6367 T9309 T9306 pobj cells,of
R6368 T9310 T9309 acl harboring,cells
R6369 T9311 T9312 amod mutant,p53
R6370 T9312 T9310 dobj p53,harboring
R6371 T9313 T9310 prep by,harboring
R6372 T9314 T9313 pcomp causing,by
R6373 T9315 T9318 amod hypoploidy,fragmentation
R6374 T9316 T9315 cc and,hypoploidy
R6375 T9317 T9315 conj DNA,hypoploidy
R6376 T9318 T9314 dobj fragmentation,causing
R6377 T9319 T9322 punct (,al.
R6378 T9320 T9322 compound Chiang,al.
R6379 T9321 T9322 nmod et,al.
R6380 T9322 T9314 ccomp al.,causing
R6381 T9323 T9322 punct ",",al.
R6382 T9324 T9322 npadvmod 2012,al.
R6383 T9325 T9322 punct ),al.
R6384 T9326 T9300 punct .,demonstrated
R6385 T9327 T9331 advmod However,has
R6386 T9328 T9331 punct ",",has
R6387 T9329 T9330 compound ectopic,WWOX
R6388 T9330 T9331 nsubj WWOX,has
R6389 T9331 T9331 ROOT has,has
R6390 T9332 T9333 det no,effect
R6391 T9333 T9331 dobj effect,has
R6392 T9334 T9333 prep with,effect
R6393 T9335 T9336 nsubj U87-MG,expressing
R6394 T9336 T9334 pcomp expressing,with
R6395 T9337 T9339 amod wild,p53
R6396 T9338 T9339 compound type,p53
R6397 T9339 T9336 dobj p53,expressing
R6398 T9340 T9331 punct .,has
R6399 T9341 T9345 prep Unlike,induces
R6400 T9342 T9341 pobj TMZ,Unlike
R6401 T9343 T9345 punct ",",induces
R6402 T9344 T9345 nsubj WWOX,induces
R6403 T9345 T9345 ROOT induces,induces
R6404 T9346 T9345 dobj apoptosis,induces
R6405 T9347 T9346 prep of,apoptosis
R6406 T9348 T9349 compound U373-MG,cells
R6407 T9349 T9347 pobj cells,of
R6408 T9350 T9345 prep via,induces
R6409 T9351 T9355 det a,pathway
R6410 T9352 T9355 amod mitochondria-independent,pathway
R6411 T9353 T9352 cc and,mitochondria-independent
R6412 T9354 T9352 conj caspase-3-independent,mitochondria-independent
R6413 T9355 T9350 pobj pathway,via
R6414 T9356 T9359 punct (,al.
R6415 T9357 T9359 compound Chiang,al.
R6416 T9358 T9359 nmod et,al.
R6417 T9359 T9345 advcl al.,induces
R6418 T9360 T9359 punct ",",al.
R6419 T9361 T9359 npadvmod 2012,al.
R6420 T9362 T9359 punct ),al.
R6421 T9363 T9345 punct .,induces
R6422 T9364 T9368 mark While,are
R6423 T9365 T9367 det the,mechanisms
R6424 T9366 T9367 amod underlying,mechanisms
R6425 T9367 T9368 nsubj mechanisms,are
R6426 T9368 T9372 advcl are,is
R6427 T9369 T9368 acomp unknown,are
R6428 T9370 T9372 punct ",",is
R6429 T9371 T9372 nsubj it,is
R6430 T9372 T9372 ROOT is,is
R6431 T9373 T9372 acomp reasonable,is
R6432 T9374 T9375 aux to,assume
R6433 T9375 T9372 xcomp assume,is
R6434 T9376 T9383 mark that,depends
R6435 T9377 T9378 det the,survival
R6436 T9378 T9383 nsubj survival,depends
R6437 T9379 T9378 prep of,survival
R6438 T9380 T9382 amod human,cells
R6439 T9381 T9382 compound glioblastoma,cells
R6440 T9382 T9379 pobj cells,of
R6441 T9383 T9375 ccomp depends,assume
R6442 T9384 T9383 prep upon,depends
R6443 T9385 T9384 pobj interactions,upon
R6444 T9386 T9385 prep between,interactions
R6445 T9387 T9388 det the,gain-of-function
R6446 T9388 T9386 pobj gain-of-function,between
R6447 T9389 T9388 prep of,gain-of-function
R6448 T9390 T9391 compound p53,mutants
R6449 T9391 T9389 pobj mutants,of
R6450 T9392 T9391 cc and,mutants
R6451 T9393 T9391 conj WWOX,mutants
R6452 T9394 T9372 punct .,is
R6453 T9395 T9396 compound Activated,WWOX
R6454 T9396 T9397 nsubj WWOX,binds
R6455 T9397 T9397 ROOT binds,binds
R6456 T9398 T9399 amod wild,type
R6457 T9399 T9400 compound type,p53
R6458 T9400 T9397 dobj p53,binds
R6459 T9401 T9397 prep with,binds
R6460 T9402 T9403 compound Ser46,phosphorylation
R6461 T9403 T9401 pobj phosphorylation,with
R6462 T9404 T9407 punct (,al.
R6463 T9405 T9407 compound Chang,al.
R6464 T9406 T9407 nmod et,al.
R6465 T9407 T9407 ROOT al.,al.
R6466 T9408 T9407 punct ",",al.
R6467 T9409 T9407 amod 2005b,al.
R6468 T9410 T9409 punct ),2005b
R6469 T9411 T9407 punct .,al.
R6470 T9412 T9413 compound UV,irradiation
R6471 T9413 T9414 nsubj irradiation,enhances
R6472 T9414 T9414 ROOT enhances,enhances
R6473 T9415 T9417 det the,interactions
R6474 T9416 T9417 amod binding,interactions
R6475 T9417 T9414 dobj interactions,enhances
R6476 T9418 T9414 punct .,enhances
R6477 T9419 T9433 prep Despite,remains
R6478 T9420 T9421 det the,presence
R6479 T9421 T9419 pobj presence,Despite
R6480 T9422 T9421 prep of,presence
R6481 T9423 T9422 pobj Ser46,of
R6482 T9424 T9421 prep in,presence
R6483 T9425 T9424 pobj Δ40p53,in
R6484 T9426 T9433 punct ",",remains
R6485 T9427 T9433 nsubj binding,remains
R6486 T9428 T9427 prep of,binding
R6487 T9429 T9430 det this,protein
R6488 T9430 T9428 pobj protein,of
R6489 T9431 T9427 prep with,binding
R6490 T9432 T9431 pobj WWOX,with
R6491 T9433 T9433 ROOT remains,remains
R6492 T9434 T9436 aux to,determined
R6493 T9435 T9436 auxpass be,determined
R6494 T9436 T9433 xcomp determined,remains
R6495 T9437 T9433 punct .,remains
R6496 T9438 T9439 nsubj We,postulate
R6497 T9439 T9439 ROOT postulate,postulate
R6498 T9440 T9453 mark that,appear
R6499 T9441 T9453 prep in,appear
R6500 T9442 T9443 compound GBM,cells
R6501 T9443 T9441 pobj cells,in
R6502 T9444 T9453 punct ",",appear
R6503 T9445 T9447 preconj both,type
R6504 T9446 T9447 amod wild,type
R6505 T9447 T9453 nsubj type,appear
R6506 T9448 T9452 nmod p53,proteins
R6507 T9449 T9448 cc and,p53
R6508 T9450 T9448 conj ectopic,p53
R6509 T9451 T9452 compound WWOX,proteins
R6510 T9452 T9453 nsubj proteins,appear
R6511 T9453 T9439 ccomp appear,postulate
R6512 T9454 T9455 aux to,have
R6513 T9455 T9453 xcomp have,appear
R6514 T9456 T9458 det a,antagonism
R6515 T9457 T9458 amod functional,antagonism
R6516 T9458 T9455 dobj antagonism,have
R6517 T9459 T9455 punct ",",have
R6518 T9460 T9461 advmod thereby,nullifying
R6519 T9461 T9455 advcl nullifying,have
R6520 T9462 T9463 det each,other
R6521 T9463 T9464 poss other,function
R6522 T9464 T9461 dobj function,nullifying
R6523 T9465 T9464 prep in,function
R6524 T9466 T9465 pcomp inducing,in
R6525 T9467 T9466 dobj apoptosis,inducing
R6526 T9468 T9469 punct (,Figure
R6527 T9469 T9464 appos Figure,function
R6528 T9470 T9469 nummod 2,Figure
R6529 T9471 T9469 punct ),Figure
R6530 T9472 T9439 punct .,postulate
R6531 T9473 T9475 amod Mutant,proteins
R6532 T9474 T9475 compound p53,proteins
R6533 T9475 T9478 nsubj proteins,bind
R6534 T9476 T9478 aux can,bind
R6535 T9477 T9478 neg not,bind
R6536 T9478 T9478 ROOT bind,bind
R6537 T9479 T9480 compound ectopic,WWOX
R6538 T9480 T9478 dobj WWOX,bind
R6539 T9481 T9480 prep in,WWOX
R6540 T9482 T9483 compound GBM,cells
R6541 T9483 T9481 pobj cells,in
R6542 T9484 T9478 punct ",",bind
R6543 T9485 T9478 cc and,bind
R6544 T9486 T9487 nsubj WWOX,is
R6545 T9487 T9478 conj is,bind
R6546 T9488 T9487 acomp able,is
R6547 T9489 T9490 aux to,induce
R6548 T9490 T9488 xcomp induce,able
R6549 T9491 T9490 dobj apoptosis,induce
R6550 T9492 T9487 punct .,is
R6551 T9493 T9495 mark Whether,causes
R6552 T9494 T9495 nsubj WWOX,causes
R6553 T9495 T9502 advcl causes,is
R6554 T9496 T9495 dobj apoptosis,causes
R6555 T9497 T9495 prep in,causes
R6556 T9498 T9499 nsubj GBM,expressing
R6557 T9499 T9497 pcomp expressing,in
R6558 T9500 T9501 compound p53,isoforms
R6559 T9501 T9499 dobj isoforms,expressing
R6560 T9502 T9502 ROOT is,is
R6561 T9503 T9502 acomp unknown,is
R6562 T9504 T9502 cc and,is
R6563 T9505 T9502 conj remains,is
R6564 T9506 T9508 aux to,established
R6565 T9507 T9508 auxpass be,established
R6566 T9508 T9505 xcomp established,remains
R6567 T9509 T9502 punct .,is