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PMC:3317373 / 130-1289 JSONTXT 23 Projects

Annnotations TAB TSV DIC JSON TextAE

Id Subject Object Predicate Lexical cue
T330 0-2 PRP denotes It
T331 3-6 VBZ denotes has
T332 7-11 VBN denotes been
T333 12-18 VBN denotes proved
T334 19-23 IN denotes that
T335 24-28 JJ denotes Nrf2
T336 29-38 NN denotes depletion
T337 39-47 VBZ denotes enhances
T338 48-60 JJ denotes inflammatory
T339 61-68 NN denotes process
T340 69-76 IN denotes through
T341 77-87 NN denotes activation
T342 88-90 IN denotes of
T343 91-96 NN denotes NF-κB
T344 97-99 IN denotes in
T345 100-103 DT denotes the
T346 104-109 NN denotes brain
T347 110-115 IN denotes after
T348 116-119 NNP denotes TBI
T349 119-120 , denotes ,
T350 121-124 CC denotes but
T351 125-131 RB denotes little
T352 132-134 VBZ denotes is
T353 135-140 VBN denotes known
T354 141-146 IN denotes about
T355 147-150 DT denotes the
T356 151-163 NN denotes relationship
T357 164-171 IN denotes between
T358 172-176 NNP denotes Nrf2
T359 177-180 CC denotes and
T360 181-186 NNP denotes NF-κB
T361 187-189 IN denotes in
T362 190-200 NNS denotes astrocytes
T363 201-206 IN denotes after
T364 207-210 NNP denotes TBI
T365 210-211 . denotes .
T366 212-217 RB denotes Hence
T367 217-218 , denotes ,
T368 219-221 PRP denotes we
T369 222-226 VBD denotes used
T370 227-234 JJ denotes primary
T371 235-243 JJ denotes cultured
T372 244-254 NNS denotes astrocytes
T373 255-259 IN denotes from
T374 260-266 DT denotes either
T375 267-271 JJ denotes Nrf2
T376 272-280 NN denotes wildtype
T377 281-283 CC denotes or
T378 284-292 NN denotes knockout
T379 293-297 NNS denotes mice
T380 298-300 TO denotes to
T381 301-306 VB denotes study
T382 307-310 DT denotes the
T383 311-320 NN denotes influence
T384 321-323 IN denotes of
T385 324-328 NNP denotes Nrf2
T386 329-331 IN denotes on
T387 332-335 DT denotes the
T388 336-346 NN denotes activation
T389 347-349 IN denotes of
T390 350-355 NNP denotes NF-κB
T391 356-359 CC denotes and
T392 360-370 NN denotes expression
T393 371-373 IN denotes of
T394 374-389 JJ denotes proinflammatory
T395 390-399 NNS denotes cytokines
T396 400-402 IN denotes in
T397 403-404 DT denotes a
T398 405-410 NN denotes model
T399 411-413 IN denotes of
T400 414-417 NNP denotes TBI
T401 418-420 IN denotes in
T402 421-426 NN denotes vitro
T403 426-427 . denotes .
T404 428-435 JJ denotes Primary
T405 436-444 JJ denotes cultured
T406 445-455 NNS denotes astrocytes
T407 456-460 VBD denotes were
T408 461-470 VBN denotes scratched
T409 471-473 TO denotes to
T410 474-479 VB denotes mimic
T411 480-483 DT denotes the
T412 484-493 JJ denotes traumatic
T413 494-500 NN denotes injury
T414 501-503 IN denotes in
T415 504-509 NN denotes vitro
T416 509-510 . denotes .
T417 511-515 RB denotes Then
T418 516-519 DT denotes the
T419 520-531 JJ denotes DNA-binding
T420 532-540 NN denotes activity
T421 541-543 IN denotes of
T422 544-549 NN denotes NF-κB
T423 550-553 VBD denotes was
T424 554-563 VBN denotes evaluated
T425 564-566 IN denotes by
T426 567-571 NNP denotes EMSA
T427 571-572 . denotes .
T428 573-576 DT denotes The
T429 577-581 NNP denotes mRNA
T430 582-585 CC denotes and
T431 586-593 NN denotes protein
T432 594-600 NNS denotes levels
T433 601-603 IN denotes of
T434 604-609 NNP denotes TNF-α
T435 609-610 , denotes ,
T436 611-616 NNP denotes IL-1β
T437 616-617 , denotes ,
T438 618-622 NNP denotes IL-6
T439 622-623 , denotes ,
T440 624-627 CC denotes and
T441 628-632 NNP denotes MMP9
T442 633-637 VBD denotes were
T443 638-642 RB denotes also
T444 643-652 VBN denotes evaluated
T445 652-653 . denotes .
T446 654-661 NN denotes Gelatin
T447 662-672 NN denotes zymography
T448 673-676 VBD denotes was
T449 677-686 VBN denotes performed
T450 687-689 TO denotes to
T451 690-696 VB denotes detect
T452 697-700 DT denotes the
T453 701-709 NN denotes activity
T454 710-712 IN denotes of
T455 713-717 NNP denotes MMP9
T456 717-718 . denotes .
T457 719-722 DT denotes The
T458 723-731 NN denotes activity
T459 732-734 IN denotes of
T460 735-740 NNP denotes NF-κB
T461 741-744 CC denotes and
T462 745-755 NN denotes expression
T463 756-758 IN denotes of
T464 759-774 JJ denotes proinflammatory
T465 775-784 NNS denotes cytokines
T466 785-794 VBN denotes mentioned
T467 795-800 IN denotes above
T468 801-805 VBD denotes were
T469 806-817 VBN denotes upregulated
T470 818-820 IN denotes at
T471 821-823 CD denotes 24
T472 824-825 NN denotes h
T473 826-831 IN denotes after
T474 832-839 NN denotes scratch
T475 839-840 . denotes .
T476 841-844 DT denotes The
T477 845-855 NN denotes expression
T478 856-859 CC denotes and
T479 860-868 NN denotes activity
T480 869-871 IN denotes of
T481 872-876 CD denotes MMP9
T482 877-881 VBD denotes were
T483 882-886 RB denotes also
T484 887-895 VBN denotes elevated
T485 895-896 . denotes .
T486 897-900 CC denotes And
T487 901-905 JJ denotes such
T488 906-914 NN denotes tendency
T489 915-918 VBD denotes was
T490 919-923 RB denotes much
T491 924-928 JJR denotes more
T492 929-938 JJ denotes prominent
T493 939-941 IN denotes in
T494 942-946 NNP denotes Nrf2
T495 947-949 NNP denotes KO
T496 950-960 NNS denotes astrocytes
T497 961-965 IN denotes than
T498 966-970 DT denotes that
T499 971-973 IN denotes in
T500 974-976 NNP denotes WT
T501 977-987 NNS denotes astrocytes
T502 987-988 . denotes .
T503 989-994 DT denotes These
T504 995-1002 NNS denotes results
T505 1003-1010 VBP denotes suggest
T506 1011-1015 IN denotes that
T507 1016-1019 DT denotes the
T508 1020-1027 NN denotes absence
T509 1028-1030 IN denotes of
T510 1031-1035 NNP denotes Nrf2
T511 1036-1039 MD denotes may
T512 1040-1046 VB denotes induce
T513 1047-1051 RBR denotes more
T514 1052-1062 JJ denotes aggressive
T515 1063-1075 NN denotes inflammation
T516 1076-1083 IN denotes through
T517 1084-1094 NN denotes activation
T518 1095-1097 IN denotes of
T519 1098-1103 NNP denotes NF-κB
T520 1104-1107 CC denotes and
T521 1108-1118 JJ denotes downstream
T522 1119-1134 JJ denotes proinflammatory
T523 1135-1144 NNS denotes cytokines
T524 1145-1147 IN denotes in
T525 1148-1158 NNS denotes astrocytes
T526 1158-1159 . denotes .
R232 T330 T333 nsubjpass It,proved
R233 T331 T333 aux has,proved
R234 T332 T333 auxpass been,proved
R235 T333 T333 ROOT proved,proved
R236 T334 T337 mark that,enhances
R237 T335 T336 amod Nrf2,depletion
R238 T336 T337 nsubj depletion,enhances
R239 T337 T333 ccomp enhances,proved
R240 T338 T339 amod inflammatory,process
R241 T339 T337 dobj process,enhances
R242 T340 T337 prep through,enhances
R243 T341 T340 pobj activation,through
R244 T342 T341 prep of,activation
R245 T343 T342 pobj NF-κB,of
R246 T344 T341 prep in,activation
R247 T345 T346 det the,brain
R248 T346 T344 pobj brain,in
R249 T347 T337 prep after,enhances
R250 T348 T347 pobj TBI,after
R251 T349 T337 punct ",",enhances
R252 T350 T337 cc but,enhances
R253 T351 T353 advmod little,known
R254 T352 T353 auxpass is,known
R255 T353 T333 conj known,proved
R256 T354 T353 prep about,known
R257 T355 T356 det the,relationship
R258 T356 T354 pobj relationship,about
R259 T357 T356 prep between,relationship
R260 T358 T357 pobj Nrf2,between
R261 T359 T358 cc and,Nrf2
R262 T360 T358 conj NF-κB,Nrf2
R263 T361 T356 prep in,relationship
R264 T362 T361 pobj astrocytes,in
R265 T363 T356 prep after,relationship
R266 T364 T363 pobj TBI,after
R267 T365 T333 punct .,proved
R268 T366 T369 advmod Hence,used
R269 T367 T369 punct ",",used
R270 T368 T369 nsubj we,used
R271 T369 T369 ROOT used,used
R272 T370 T372 amod primary,astrocytes
R273 T371 T372 amod cultured,astrocytes
R274 T372 T369 dobj astrocytes,used
R275 T373 T372 prep from,astrocytes
R276 T374 T376 preconj either,wildtype
R277 T375 T376 amod Nrf2,wildtype
R278 T376 T373 pobj wildtype,from
R279 T377 T376 cc or,wildtype
R280 T378 T379 compound knockout,mice
R281 T379 T376 conj mice,wildtype
R282 T380 T381 aux to,study
R283 T381 T369 xcomp study,used
R284 T382 T383 det the,influence
R285 T383 T381 dobj influence,study
R286 T384 T383 prep of,influence
R287 T385 T384 pobj Nrf2,of
R288 T386 T383 prep on,influence
R289 T387 T388 det the,activation
R290 T388 T386 pobj activation,on
R291 T389 T388 prep of,activation
R292 T390 T389 pobj NF-κB,of
R293 T391 T388 cc and,activation
R294 T392 T388 conj expression,activation
R295 T393 T388 prep of,activation
R296 T394 T395 amod proinflammatory,cytokines
R297 T395 T393 pobj cytokines,of
R298 T396 T388 prep in,activation
R299 T397 T398 det a,model
R300 T398 T396 pobj model,in
R301 T399 T398 prep of,model
R302 T400 T399 pobj TBI,of
R303 T401 T388 prep in,activation
R304 T402 T401 pobj vitro,in
R305 T403 T369 punct .,used
R306 T404 T406 amod Primary,astrocytes
R307 T405 T406 amod cultured,astrocytes
R308 T406 T408 nsubjpass astrocytes,scratched
R309 T407 T408 auxpass were,scratched
R310 T408 T408 ROOT scratched,scratched
R311 T409 T410 aux to,mimic
R312 T410 T408 advcl mimic,scratched
R313 T411 T413 det the,injury
R314 T412 T413 amod traumatic,injury
R315 T413 T410 dobj injury,mimic
R316 T414 T413 prep in,injury
R317 T415 T414 pobj vitro,in
R318 T416 T408 punct .,scratched
R319 T417 T424 advmod Then,evaluated
R320 T418 T420 det the,activity
R321 T419 T420 amod DNA-binding,activity
R322 T420 T424 nsubjpass activity,evaluated
R323 T421 T420 prep of,activity
R324 T422 T421 pobj NF-κB,of
R325 T423 T424 auxpass was,evaluated
R326 T424 T424 ROOT evaluated,evaluated
R327 T425 T424 agent by,evaluated
R328 T426 T425 pobj EMSA,by
R329 T427 T424 punct .,evaluated
R330 T428 T429 det The,mRNA
R331 T429 T444 nsubjpass mRNA,evaluated
R332 T430 T429 cc and,mRNA
R333 T431 T432 compound protein,levels
R334 T432 T429 conj levels,mRNA
R335 T433 T432 prep of,levels
R336 T434 T433 pobj TNF-α,of
R337 T435 T434 punct ",",TNF-α
R338 T436 T434 conj IL-1β,TNF-α
R339 T437 T436 punct ",",IL-1β
R340 T438 T436 conj IL-6,IL-1β
R341 T439 T438 punct ",",IL-6
R342 T440 T438 cc and,IL-6
R343 T441 T438 conj MMP9,IL-6
R344 T442 T444 auxpass were,evaluated
R345 T443 T444 advmod also,evaluated
R346 T444 T444 ROOT evaluated,evaluated
R347 T445 T444 punct .,evaluated
R348 T446 T447 compound Gelatin,zymography
R349 T447 T449 nsubjpass zymography,performed
R350 T448 T449 auxpass was,performed
R351 T449 T449 ROOT performed,performed
R352 T450 T451 aux to,detect
R353 T451 T449 advcl detect,performed
R354 T452 T453 det the,activity
R355 T453 T451 dobj activity,detect
R356 T454 T453 prep of,activity
R357 T455 T454 pobj MMP9,of
R358 T456 T449 punct .,performed
R359 T457 T458 det The,activity
R360 T458 T469 nsubjpass activity,upregulated
R361 T459 T458 prep of,activity
R362 T460 T459 pobj NF-κB,of
R363 T461 T458 cc and,activity
R364 T462 T458 conj expression,activity
R365 T463 T462 prep of,expression
R366 T464 T465 amod proinflammatory,cytokines
R367 T465 T463 pobj cytokines,of
R368 T466 T465 acl mentioned,cytokines
R369 T467 T466 advmod above,mentioned
R370 T468 T469 auxpass were,upregulated
R371 T469 T469 ROOT upregulated,upregulated
R372 T470 T469 prep at,upregulated
R373 T471 T472 nummod 24,h
R374 T472 T470 pobj h,at
R375 T473 T469 prep after,upregulated
R376 T474 T473 pobj scratch,after
R377 T475 T469 punct .,upregulated
R378 T476 T477 det The,expression
R379 T477 T484 nsubjpass expression,elevated
R380 T478 T477 cc and,expression
R381 T479 T477 conj activity,expression
R382 T480 T477 prep of,expression
R383 T481 T480 pobj MMP9,of
R384 T482 T484 auxpass were,elevated
R385 T483 T484 advmod also,elevated
R386 T484 T484 ROOT elevated,elevated
R387 T485 T484 punct .,elevated
R388 T486 T489 cc And,was
R389 T487 T488 amod such,tendency
R390 T488 T489 nsubj tendency,was
R391 T489 T489 ROOT was,was
R392 T490 T491 advmod much,more
R393 T491 T492 advmod more,prominent
R394 T492 T489 acomp prominent,was
R395 T493 T492 prep in,prominent
R396 T494 T495 compound Nrf2,KO
R397 T495 T496 compound KO,astrocytes
R398 T496 T493 pobj astrocytes,in
R399 T497 T492 prep than,prominent
R400 T498 T497 pobj that,than
R401 T499 T498 prep in,that
R402 T500 T501 compound WT,astrocytes
R403 T501 T499 pobj astrocytes,in
R404 T502 T489 punct .,was
R405 T503 T504 det These,results
R406 T504 T505 nsubj results,suggest
R407 T505 T505 ROOT suggest,suggest
R408 T506 T512 mark that,induce
R409 T507 T508 det the,absence
R410 T508 T512 nsubj absence,induce
R411 T509 T508 prep of,absence
R412 T510 T509 pobj Nrf2,of
R413 T511 T512 aux may,induce
R414 T512 T505 ccomp induce,suggest
R415 T513 T514 advmod more,aggressive
R416 T514 T515 amod aggressive,inflammation
R417 T515 T512 dobj inflammation,induce
R418 T516 T512 prep through,induce
R419 T517 T516 pobj activation,through
R420 T518 T517 prep of,activation
R421 T519 T518 pobj NF-κB,of
R422 T520 T517 cc and,activation
R423 T521 T523 amod downstream,cytokines
R424 T522 T523 compound proinflammatory,cytokines
R425 T523 T517 conj cytokines,activation
R426 T524 T512 prep in,induce
R427 T525 T524 pobj astrocytes,in
R428 T526 T505 punct .,suggest