| Id |
Subject |
Object |
Predicate |
Lexical cue |
Negation |
Speculation |
| T71 |
0-7 |
Protein |
denotes |
SHARPIN |
|
|
| T72 |
177-186 |
Negative_regulation |
denotes |
mutations |
|
|
| T73 |
194-201 |
Protein |
denotes |
Sharpin |
|
|
| T74 |
203-249 |
Protein |
denotes |
SHANK-associated RH domain-interacting protein |
|
|
| T75 |
266-272 |
Protein |
denotes |
Rbckl1 |
|
|
| T76 |
274-279 |
Protein |
denotes |
Sipl1 |
|
|
| T77 |
627-634 |
Protein |
denotes |
SHARPIN |
|
|
| T78 |
635-644 |
Negative_regulation |
denotes |
deficient |
|
|
| T79 |
749-756 |
Protein |
denotes |
SHARPIN |
|
|
| T80 |
758-768 |
Negative_regulation |
denotes |
deficiency |
|
|
| T81 |
1053-1057 |
Protein |
denotes |
CD40 |
|
|
| T82 |
1059-1063 |
Protein |
denotes |
CD80 |
|
|
| T83 |
1069-1073 |
Protein |
denotes |
CD86 |
|
|
| T84 |
1095-1102 |
Protein |
denotes |
SHARPIN |
|
|
| T85 |
1103-1112 |
Negative_regulation |
denotes |
deficient |
|
|
| T86 |
1122-1129 |
Negative_regulation |
denotes |
reduced |
|
|
| T87 |
1122-1129 |
Negative_regulation |
denotes |
reduced |
|
|
| T88 |
1122-1129 |
Negative_regulation |
denotes |
reduced |
|
|
| T89 |
1122-1129 |
Negative_regulation |
denotes |
reduced |
|
|
| T90 |
1130-1143 |
Transcription |
denotes |
transcription |
|
|
| T91 |
1130-1143 |
Transcription |
denotes |
transcription |
|
|
| T93 |
1148-1157 |
Gene_expression |
denotes |
secretion |
|
|
| T92 |
1148-1157 |
Gene_expression |
denotes |
secretion |
|
|
| T94 |
1188-1191 |
Protein |
denotes |
IL6 |
|
|
| T95 |
1202-1207 |
Protein |
denotes |
GMCSF |
|
|
| T96 |
1296-1301 |
Protein |
denotes |
MAPK1 |
|
|
| T97 |
1302-1303 |
Protein |
denotes |
3 |
|
|
| T98 |
1305-1309 |
Protein |
denotes |
ERK1 |
|
|
| T99 |
1310-1311 |
Protein |
denotes |
2 |
|
|
| T100 |
1317-1323 |
Protein |
denotes |
MAPK11 |
|
|
| T101 |
1324-1326 |
Protein |
denotes |
12 |
|
|
| T102 |
1327-1329 |
Protein |
denotes |
13 |
|
|
| T103 |
1330-1332 |
Protein |
denotes |
14 |
|
|
| T104 |
1363-1367 |
Protein |
denotes |
TBK1 |
|
|
| T105 |
1592-1596 |
Negative_regulation |
denotes |
loss |
|
|
| T106 |
1600-1607 |
Protein |
denotes |
Sharpin |
|
|
| T950 |
1771-1778 |
Protein |
denotes |
SHARPIN |
|
|
| T951 |
1908-1917 |
Gene_expression |
denotes |
expressed |
|
|
| T952 |
1970-1989 |
Negative_regulation |
denotes |
recessive mutations |
|
|
| T953 |
1997-2004 |
Protein |
denotes |
Sharpin |
|
|
| T954 |
2152-2161 |
Positive_regulation |
denotes |
resulting |
|
|
| T955 |
2152-2161 |
Positive_regulation |
denotes |
resulting |
|
|
| T956 |
2175-2186 |
Negative_regulation |
denotes |
termination |
|
|
| T957 |
2195-2204 |
Transcription |
denotes |
synthesis |
|
|
| T958 |
2209-2216 |
Negative_regulation |
denotes |
absence |
|
|
| T959 |
2866-2875 |
Negative_regulation |
denotes |
decreased |
|
|
| T960 |
2876-2885 |
Gene_expression |
denotes |
secretion |
|
|
| T961 |
2889-2893 |
Protein |
denotes |
IFNγ |
|
|
| T962 |
3088-3102 |
Negative_regulation |
denotes |
Neutralization |
|
|
| T963 |
3106-3109 |
Protein |
denotes |
IL5 |
|
|
| T964 |
3148-3151 |
Protein |
denotes |
IL5 |
|
|
| T965 |
3152-3161 |
Negative_regulation |
denotes |
deficient |
|
|
| T966 |
3341-3348 |
Protein |
denotes |
SHARPIN |
|
|
| T967 |
3445-3449 |
Protein |
denotes |
TNFα |
|
|
| T968 |
3493-3500 |
Protein |
denotes |
SHARPIN |
|
|
| T969 |
3501-3510 |
Negative_regulation |
denotes |
deficient |
|
|
| T970 |
3563-3567 |
Protein |
denotes |
TNFα |
|
|
| T971 |
4215-4222 |
Protein |
denotes |
SHARPIN |
|
|
| T972 |
4223-4232 |
Negative_regulation |
denotes |
deficient |
|
|
| T973 |
4276-4280 |
Negative_regulation |
denotes |
lack |
|
|
| T974 |
4284-4291 |
Protein |
denotes |
SHARPIN |
|
|
| T975 |
4569-4576 |
Protein |
denotes |
SHARPIN |
|
|
| T976 |
4668-4675 |
Protein |
denotes |
SHARPIN |
|
|
| T977 |
4676-4685 |
Negative_regulation |
denotes |
deficient |
|
|
| T2199 |
4755-4762 |
Protein |
denotes |
Sharpin |
|
|
| T2200 |
4777-4784 |
Protein |
denotes |
SHARPIN |
|
|
| T2201 |
4936-4943 |
Protein |
denotes |
SHARPIN |
|
|
| T2202 |
5150-5157 |
Protein |
denotes |
SHARPIN |
|
|
| T2203 |
5214-5221 |
Protein |
denotes |
SHARPIN |
|
|
| T2204 |
5284-5293 |
Negative_regulation |
denotes |
mutations |
|
|
| T2205 |
5307-5314 |
Protein |
denotes |
Sharpin |
|
|
| T2206 |
5524-5534 |
Transcription |
denotes |
expression |
|
|
| T2207 |
5538-5545 |
Protein |
denotes |
Sharpin |
|
|
| T2208 |
5678-5685 |
Protein |
denotes |
Sharpin |
|
|
| T2209 |
5695-5702 |
Transcription |
denotes |
present |
|
|
| T2210 |
5771-5780 |
Negative_regulation |
denotes |
decreased |
|
|
| T2211 |
5825-5834 |
Negative_regulation |
denotes |
reduction |
|
|
| T2212 |
5838-5845 |
Protein |
denotes |
Sharpin |
|
|
| T2213 |
5924-5931 |
Protein |
denotes |
Sharpin |
|
|
| T2214 |
5993-6004 |
Entity |
denotes |
cytoplasmic |
|
|
| T2215 |
6005-6017 |
Localization |
denotes |
localization |
|
|
| T2216 |
6025-6032 |
Protein |
denotes |
SHARPIN |
|
|
| T12755 |
6129-6136 |
Protein |
denotes |
SHARPIN |
|
|
| T12756 |
6355-6362 |
Protein |
denotes |
SHARPIN |
|
|
| T12757 |
6716-6726 |
Transcription |
denotes |
mRNA level |
|
true |
| T12758 |
6730-6737 |
Protein |
denotes |
Sharpin |
|
|
| T12759 |
7007-7014 |
Protein |
denotes |
SHARPIN |
|
|
| T12760 |
7183-7190 |
Protein |
denotes |
SHARPIN |
|
|
| T12761 |
7207-7216 |
Entity |
denotes |
cytoplasm |
|
|
| T12762 |
7217-7226 |
Localization |
denotes |
localized |
|
|
| T3262 |
7401-7408 |
Protein |
denotes |
Sharpin |
|
|
| T3241 |
7409-7417 |
Negative_regulation |
denotes |
mutation |
|
|
| T3273 |
7536-7541 |
Protein |
denotes |
CD11c |
|
|
| T3274 |
7542-7546 |
Protein |
denotes |
CD8α |
|
|
| T3275 |
7552-7557 |
Protein |
denotes |
CD11c |
|
|
| T3280 |
7558-7562 |
Protein |
denotes |
CD8α |
|
|
| T3276 |
7596-7601 |
Protein |
denotes |
CD11c |
|
|
| T3277 |
7602-7608 |
Protein |
denotes |
PDCA-1 |
|
|
| T3278 |
7827-7834 |
Protein |
denotes |
SHARPIN |
|
|
| T3252 |
7835-7845 |
Negative_regulation |
denotes |
deficiency |
|
|
| T3279 |
8162-8169 |
Protein |
denotes |
Sharpin |
|
|
| T3255 |
8170-8178 |
Negative_regulation |
denotes |
mutation |
|
|
| T13263 |
8308-8315 |
Protein |
denotes |
Sharpin |
|
|
| T13264 |
8316-8324 |
Negative_regulation |
denotes |
mutation |
|
|
| T3263 |
9763-9768 |
Protein |
denotes |
CD11c |
|
|
| T3264 |
9830-9834 |
Protein |
denotes |
CD40 |
|
|
| T3265 |
9836-9840 |
Protein |
denotes |
CD80 |
|
|
| T3266 |
9846-9850 |
Protein |
denotes |
CD86 |
|
|
| T3267 |
9856-9860 |
Protein |
denotes |
TLR3 |
|
|
| T3256 |
9861-9867 |
Binding |
denotes |
ligand |
|
|
| T3268 |
9885-9889 |
Protein |
denotes |
TLR4 |
|
|
| T3257 |
9890-9896 |
Binding |
denotes |
ligand |
|
|
| T3242 |
10056-10064 |
Positive_regulation |
denotes |
resulted |
|
|
| T3258 |
10056-10064 |
Positive_regulation |
denotes |
resulted |
|
|
| T3260 |
10056-10064 |
Positive_regulation |
denotes |
resulted |
|
|
| T3243 |
10068-10077 |
Positive_regulation |
denotes |
increased |
|
|
| T3259 |
10068-10077 |
Positive_regulation |
denotes |
increased |
|
|
| T3261 |
10068-10077 |
Positive_regulation |
denotes |
increased |
|
|
| T3244 |
10078-10088 |
Gene_expression |
denotes |
expression |
|
|
| T3245 |
10078-10088 |
Gene_expression |
denotes |
expression |
|
|
| T3246 |
10078-10088 |
Gene_expression |
denotes |
expression |
|
|
| T3269 |
10092-10096 |
Protein |
denotes |
CD40 |
|
|
| T3270 |
10098-10102 |
Protein |
denotes |
CD80 |
|
|
| T3271 |
10108-10112 |
Protein |
denotes |
CD86 |
|
|
| T3247 |
10144-10154 |
Regulation |
denotes |
difference |
true |
|
| T3249 |
10144-10154 |
Regulation |
denotes |
difference |
true |
|
| T3251 |
10144-10154 |
Regulation |
denotes |
difference |
true |
|
| T3248 |
10162-10172 |
Gene_expression |
denotes |
expression |
|
|
| T3250 |
10162-10172 |
Gene_expression |
denotes |
expression |
|
|
| T3253 |
10162-10172 |
Gene_expression |
denotes |
expression |
|
|
| T3272 |
10239-10246 |
Protein |
denotes |
SHARPIN |
|
|
| T3254 |
10247-10257 |
Negative_regulation |
denotes |
deficiency |
|
|
| T3805 |
10426-10434 |
Positive_regulation |
denotes |
resulted |
|
|
| T3806 |
10426-10434 |
Positive_regulation |
denotes |
resulted |
|
|
| T3807 |
10438-10447 |
Gene_expression |
denotes |
secretion |
|
|
| T3808 |
10438-10447 |
Gene_expression |
denotes |
secretion |
|
|
| T3809 |
10451-10454 |
Protein |
denotes |
IL6 |
|
|
| T3810 |
10469-10474 |
Protein |
denotes |
GMCSF |
|
|
| T3811 |
10532-10540 |
Gene_expression |
denotes |
produced |
|
|
| T3812 |
10532-10540 |
Gene_expression |
denotes |
produced |
|
|
| T3813 |
10555-10559 |
Positive_regulation |
denotes |
less |
true |
|
| T3814 |
10555-10559 |
Positive_regulation |
denotes |
less |
true |
|
| T3815 |
10815-10822 |
Protein |
denotes |
Sharpin |
|
|
| T3816 |
10823-10832 |
Negative_regulation |
denotes |
deficient |
|
|
| T3817 |
10870-10877 |
Protein |
denotes |
Sharpin |
|
|
| T3818 |
11091-11098 |
Protein |
denotes |
SHARPIN |
|
|
| T3819 |
11195-11198 |
Protein |
denotes |
Il6 |
|
|
| T3820 |
11200-11207 |
Protein |
denotes |
Il12p40 |
|
|
| T3821 |
11209-11214 |
Protein |
denotes |
Gmcsf |
|
|
| T3822 |
11220-11224 |
Protein |
denotes |
Ifnb |
|
|
| T13802 |
11679-11682 |
Protein |
denotes |
IL6 |
|
|
| T13803 |
11688-11693 |
Protein |
denotes |
GMCSF |
|
|
| T13804 |
11912-11915 |
Protein |
denotes |
IL6 |
|
|
| T13805 |
11981-11988 |
Protein |
denotes |
Sharpin |
|
|
| T14248 |
12685-12695 |
Transcription |
denotes |
expression |
|
true |
| T14249 |
12685-12695 |
Transcription |
denotes |
expression |
|
true |
| T14250 |
12685-12695 |
Transcription |
denotes |
expression |
|
true |
| T14251 |
12685-12695 |
Transcription |
denotes |
expression |
|
true |
| T14252 |
12699-12706 |
Protein |
denotes |
Il12p40 |
|
|
| T14253 |
12714-12717 |
Protein |
denotes |
Il6 |
|
|
| T14254 |
12725-12730 |
Protein |
denotes |
Gmcsf |
|
|
| T14255 |
12742-12746 |
Protein |
denotes |
Ifnb |
|
|
| T4410 |
13365-13369 |
Protein |
denotes |
TLR4 |
|
|
| T4411 |
13394-13398 |
Protein |
denotes |
CD14 |
|
|
| T4412 |
13403-13435 |
Protein |
denotes |
myeloid differentiation factor 2 |
|
|
| T4413 |
13437-13440 |
Protein |
denotes |
MD2 |
|
|
| T4414 |
13441-13445 |
Protein |
denotes |
LY96 |
|
|
| T4415 |
13493-13503 |
Gene_expression |
denotes |
expression |
|
|
| T4416 |
13493-13503 |
Gene_expression |
denotes |
expression |
|
|
| T4417 |
13493-13503 |
Gene_expression |
denotes |
expression |
|
|
| T4418 |
13514-13518 |
Protein |
denotes |
CD14 |
|
|
| T4419 |
13523-13527 |
Protein |
denotes |
TLR4 |
|
|
| T4420 |
13528-13531 |
Protein |
denotes |
MD2 |
|
|
| T4421 |
13604-13613 |
Gene_expression |
denotes |
secretion |
|
true |
| T4422 |
13643-13647 |
Protein |
denotes |
IL10 |
|
|
| T4423 |
13786-13791 |
Positive_regulation |
denotes |
lower |
true |
|
| T4424 |
13792-13798 |
Gene_expression |
denotes |
levels |
|
|
| T4425 |
13802-13806 |
Protein |
denotes |
IL10 |
|
|
| T4426 |
13858-13862 |
Protein |
denotes |
IL10 |
|
|
| T4427 |
13932-13941 |
Positive_regulation |
denotes |
Increased |
|
|
| T4428 |
13942-13952 |
Gene_expression |
denotes |
expression |
|
|
| T4429 |
14002-14005 |
Protein |
denotes |
A20 |
|
|
| T4430 |
14062-14078 |
Transcription |
denotes |
transcript level |
|
|
| T4431 |
14082-14085 |
Protein |
denotes |
A20 |
|
|
| T4432 |
14090-14095 |
Positive_regulation |
denotes |
lower |
true |
|
| T4433 |
14170-14184 |
Positive_regulation |
denotes |
overexpression |
|
|
| T4434 |
14188-14191 |
Protein |
denotes |
A20 |
|
|
| T14565 |
14284-14290 |
Negative_regulation |
denotes |
Normal |
true |
|
| T14566 |
14284-14290 |
Negative_regulation |
denotes |
Normal |
true |
|
| T14567 |
14291-14295 |
Protein |
denotes |
TLR4 |
|
|
| T14568 |
14300-14303 |
Protein |
denotes |
MD2 |
|
|
| T14569 |
14304-14314 |
Gene_expression |
denotes |
expression |
|
|
| T14570 |
14304-14314 |
Gene_expression |
denotes |
expression |
|
|
| T14571 |
14319-14328 |
Negative_regulation |
denotes |
decreased |
|
|
| T14572 |
14319-14328 |
Negative_regulation |
denotes |
decreased |
|
|
| T14573 |
14329-14333 |
Protein |
denotes |
IL10 |
|
|
| T14574 |
14334-14343 |
Gene_expression |
denotes |
secretion |
|
|
| T14575 |
14348-14351 |
Protein |
denotes |
A20 |
|
|
| T14576 |
14352-14362 |
Gene_expression |
denotes |
expression |
|
|
| T14577 |
14764-14768 |
Protein |
denotes |
IL10 |
|
|
| T14578 |
14992-15002 |
Gene_expression |
denotes |
production |
|
true |
| T14579 |
15006-15009 |
Protein |
denotes |
A20 |
|
|
| T4435 |
15035-15039 |
Protein |
denotes |
TLR3 |
|
|
| T4436 |
15040-15041 |
Protein |
denotes |
4 |
|
|
| T4437 |
15154-15158 |
Protein |
denotes |
TBK1 |
|
|
| T4438 |
15159-15163 |
Protein |
denotes |
IRF3 |
|
|
| T4439 |
15224-15228 |
Protein |
denotes |
TBK1 |
|
|
| T4440 |
15229-15233 |
Protein |
denotes |
IRF3 |
|
|
| T4441 |
15319-15326 |
Protein |
denotes |
Sharpin |
|
|
| T4442 |
15327-15336 |
Negative_regulation |
denotes |
deficient |
|
|
| T4443 |
15395-15399 |
Protein |
denotes |
IKK1 |
|
|
| T4444 |
15400-15401 |
Protein |
denotes |
2 |
|
|
| T4445 |
15444-15452 |
Positive_regulation |
denotes |
allowing |
|
|
| T4446 |
15444-15452 |
Positive_regulation |
denotes |
allowing |
|
|
| T4447 |
15453-15468 |
Phosphorylation |
denotes |
phosphorylation |
|
|
| T4448 |
15484-15492 |
Positive_regulation |
denotes |
mediated |
|
|
| T4449 |
15493-15504 |
Protein_catabolism |
denotes |
degradation |
|
|
| T4450 |
15528-15532 |
Protein |
denotes |
IκBα |
|
|
| T4451 |
15608-15622 |
Phosphorylation |
denotes |
phosphorylated |
|
|
| T4452 |
15608-15622 |
Phosphorylation |
denotes |
phosphorylated |
|
|
| T4453 |
15608-15622 |
Phosphorylation |
denotes |
phosphorylated |
|
|
| T4454 |
15623-15627 |
Protein |
denotes |
IKK1 |
|
|
| T4455 |
15628-15629 |
Protein |
denotes |
2 |
|
|
| T4456 |
15633-15637 |
Protein |
denotes |
IKK1 |
|
|
| T4457 |
15638-15639 |
Protein |
denotes |
2 |
|
|
| T4458 |
15645-15649 |
Protein |
denotes |
IκBα |
|
|
| T4459 |
15653-15657 |
Protein |
denotes |
IκBα |
|
|
| T4460 |
15714-15723 |
Negative_regulation |
denotes |
decreased |
|
|
| T4461 |
15714-15723 |
Negative_regulation |
denotes |
decreased |
|
|
| T4462 |
15714-15723 |
Negative_regulation |
denotes |
decreased |
|
|
| T4463 |
15818-15822 |
Protein |
denotes |
TBK1 |
|
|
| T4464 |
15824-15828 |
Protein |
denotes |
ERK1 |
|
|
| T4465 |
15829-15830 |
Protein |
denotes |
2 |
|
|
| T4466 |
15840-15855 |
Phosphorylation |
denotes |
phosphorylation |
|
|
| T4467 |
15840-15855 |
Phosphorylation |
denotes |
phosphorylation |
|
|
| T4468 |
15840-15855 |
Phosphorylation |
denotes |
phosphorylation |
|
|
| T4469 |
15919-15926 |
Negative_regulation |
denotes |
absence |
|
|
| T4470 |
15941-15948 |
Protein |
denotes |
SHARPIN |
|
|
| T4471 |
15995-15999 |
Protein |
denotes |
TBK1 |
|
|
| T4472 |
16000-16004 |
Protein |
denotes |
IRF3 |
|
|
| T4473 |
16006-16010 |
Protein |
denotes |
ERK1 |
|
|
| T4474 |
16011-16012 |
Protein |
denotes |
2 |
|
|
| T14985 |
16393-16397 |
Protein |
denotes |
TBK1 |
|
|
| T14986 |
16398-16402 |
Protein |
denotes |
IRF3 |
|
|
| T14987 |
16404-16408 |
Protein |
denotes |
ERK1 |
|
|
| T14988 |
16409-16410 |
Protein |
denotes |
2 |
|
|
| T14989 |
16440-16450 |
Protein |
denotes |
Beta-actin |
|
|
| T14990 |
16505-16509 |
Protein |
denotes |
IKK1 |
|
|
| T14991 |
16510-16511 |
Protein |
denotes |
2 |
|
|
| T14992 |
16518-16522 |
Protein |
denotes |
IκBα |
|
|
| T5789 |
16851-16858 |
Negative_regulation |
denotes |
absence |
|
|
| T5790 |
16862-16869 |
Protein |
denotes |
SHARPIN |
|
|
| T5791 |
17046-17054 |
Positive_regulation |
denotes |
elicited |
|
|
| T5792 |
17062-17066 |
Protein |
denotes |
IFNγ |
|
|
| T5793 |
17067-17077 |
Gene_expression |
denotes |
production |
|
|
| T5794 |
17091-17104 |
Gene_expression |
denotes |
concentration |
|
|
| T5795 |
17108-17112 |
Protein |
denotes |
IFNγ |
|
|
| T5796 |
17160-17165 |
Positive_regulation |
denotes |
lower |
true |
|
| T5797 |
17273-17277 |
Protein |
denotes |
TLR3 |
|
|
| T5798 |
17278-17279 |
Protein |
denotes |
4 |
|
|
| T5799 |
17280-17288 |
Positive_regulation |
denotes |
agonists |
|
|
| T5800 |
17280-17288 |
Positive_regulation |
denotes |
agonists |
|
|
| T5801 |
17294-17298 |
Protein |
denotes |
TLR2 |
|
|
| T5802 |
17299-17305 |
Binding |
denotes |
ligand |
|
|
| T5803 |
17306-17313 |
Protein |
denotes |
Pam3CYS |
|
|
| T5804 |
17395-17402 |
Protein |
denotes |
Pam3CYS |
|
|
| T5805 |
17419-17426 |
Positive_regulation |
denotes |
induced |
|
|
| T5806 |
17434-17438 |
Protein |
denotes |
IFNγ |
|
|
| T5807 |
17439-17449 |
Gene_expression |
denotes |
production |
|
|
| T5808 |
17550-17557 |
Protein |
denotes |
Pam3CYS |
|
|
| T5809 |
17666-17670 |
Protein |
denotes |
TLR2 |
|
|
| T5810 |
17720-17723 |
Protein |
denotes |
IL4 |
|
|
| T5811 |
17737-17745 |
Gene_expression |
denotes |
produced |
|
|
| T5812 |
17861-17871 |
Gene_expression |
denotes |
production |
|
|
| T5813 |
17898-17903 |
Protein |
denotes |
IL17A |
|
|
| T5814 |
17904-17913 |
Positive_regulation |
denotes |
following |
|
|
| T5815 |
18134-18137 |
Protein |
denotes |
IL2 |
|
|
| T5816 |
18138-18148 |
Gene_expression |
denotes |
production |
|
|
| T5817 |
18224-18231 |
Positive_regulation |
denotes |
induced |
|
|
| T5818 |
18232-18236 |
Positive_regulation |
denotes |
more |
|
|
| T5819 |
18237-18240 |
Protein |
denotes |
IL2 |
|
|
| T15325 |
18959-18968 |
Gene_expression |
denotes |
secretion |
|
true |
| T15326 |
18959-18968 |
Gene_expression |
denotes |
secretion |
|
true |
| T15327 |
18959-18968 |
Gene_expression |
denotes |
secretion |
|
true |
| T15328 |
18972-18976 |
Protein |
denotes |
IFNγ |
|
|
| T15329 |
18978-18981 |
Protein |
denotes |
IL4 |
|
|
| T15330 |
18987-18990 |
Protein |
denotes |
IL2 |
|
|
| T15331 |
19227-19237 |
Gene_expression |
denotes |
production |
true |
|
| T15332 |
19227-19237 |
Gene_expression |
denotes |
production |
true |
|
| T15333 |
19227-19237 |
Gene_expression |
denotes |
production |
true |
|
| T6683 |
19386-19400 |
Negative_regulation |
denotes |
null mutations |
|
|
| T6684 |
19414-19421 |
Protein |
denotes |
Sharpin |
|
|
| T6685 |
19546-19550 |
Negative_regulation |
denotes |
loss |
|
|
| T6686 |
19554-19561 |
Protein |
denotes |
SHARPIN |
|
|
| T6687 |
20029-20036 |
Protein |
denotes |
SHARPIN |
|
|
| T6688 |
20079-20089 |
Negative_regulation |
denotes |
disruption |
|
|
| T6689 |
20750-20754 |
Protein |
denotes |
TNFα |
|
|
| T6690 |
20825-20833 |
Negative_regulation |
denotes |
deletion |
|
|
| T6691 |
20837-20840 |
Protein |
denotes |
TNF |
|
|
| T6692 |
20867-20877 |
Negative_regulation |
denotes |
deficiency |
|
|
| T6693 |
20881-20888 |
Protein |
denotes |
SHARPIN |
|
|
| T6694 |
21359-21364 |
Protein |
denotes |
HMGB1 |
|
|
| T6695 |
21365-21375 |
Binding |
denotes |
recognized |
|
|
| T6696 |
21379-21383 |
Protein |
denotes |
TLR2 |
|
|
| T6697 |
21384-21385 |
Protein |
denotes |
4 |
|
|
| T6698 |
21892-21899 |
Protein |
denotes |
IL12P35 |
|
|
| T6699 |
21905-21912 |
Protein |
denotes |
IL12P40 |
|
|
| T6700 |
21913-21922 |
Negative_regulation |
denotes |
deficient |
|
|
| T6701 |
21913-21922 |
Negative_regulation |
denotes |
deficient |
|
|
| T6702 |
22008-22012 |
Protein |
denotes |
IRF3 |
|
|
| T6703 |
22274-22284 |
Positive_regulation |
denotes |
activation |
|
|
| T6704 |
22274-22284 |
Positive_regulation |
denotes |
activation |
|
|
| T6705 |
22274-22284 |
Positive_regulation |
denotes |
activation |
|
|
| T6706 |
22274-22284 |
Positive_regulation |
denotes |
activation |
|
|
| T6707 |
22288-22292 |
Protein |
denotes |
TBK1 |
|
|
| T6708 |
22293-22297 |
Protein |
denotes |
IRF3 |
|
|
| T6709 |
22299-22303 |
Protein |
denotes |
ERK1 |
|
|
| T6710 |
22304-22305 |
Protein |
denotes |
2 |
|
|
| T6711 |
22314-22321 |
Negative_regulation |
denotes |
was not |
true |
|
| T6712 |
22314-22321 |
Negative_regulation |
denotes |
was not |
true |
|
| T6713 |
22314-22321 |
Negative_regulation |
denotes |
was not |
true |
|
| T6714 |
22314-22321 |
Negative_regulation |
denotes |
was not |
true |
|
| T6715 |
22730-22737 |
Protein |
denotes |
SHARPIN |
|
|
| T6716 |
22892-22895 |
Protein |
denotes |
A20 |
|
|
| T6717 |
22900-22904 |
Protein |
denotes |
ITCH |
|
|
| T6718 |
23495-23503 |
Negative_regulation |
denotes |
deletion |
|
|
| T6719 |
23507-23514 |
Protein |
denotes |
Sharpin |
|
|
| T6720 |
23572-23579 |
Protein |
denotes |
SHARPIN |
|
|
| T6721 |
23639-23646 |
Negative_regulation |
denotes |
absence |
|
|
| T6722 |
23650-23657 |
Protein |
denotes |
Sharpin |
|
|
| T6723 |
23658-23668 |
Gene_expression |
denotes |
expression |
|
|
| T6724 |
24010-24014 |
Protein |
denotes |
p100 |
|
|
| T6725 |
24037-24040 |
Protein |
denotes |
p52 |
|
|
| T6726 |
24066-24073 |
Protein |
denotes |
SHARPIN |
|
|
| T6727 |
24074-24083 |
Negative_regulation |
denotes |
deficient |
|
|
| T6728 |
24137-24140 |
Protein |
denotes |
p52 |
|
|
| T6729 |
24141-24145 |
Protein |
denotes |
RELB |
|
|
| T6730 |
24261-24268 |
Protein |
denotes |
Sharpin |
|
|
| T6731 |
24269-24277 |
Negative_regulation |
denotes |
mutation |
|
|
| T6732 |
24414-24420 |
Binding |
denotes |
engage |
|
|
| T6733 |
24414-24420 |
Binding |
denotes |
engage |
|
|
| T6734 |
24421-24425 |
Protein |
denotes |
TLR4 |
|
|
| T6735 |
24430-24434 |
Protein |
denotes |
TLR3 |
|
|
| T6736 |
24646-24653 |
Binding |
denotes |
engages |
|
|
| T6737 |
24654-24658 |
Protein |
denotes |
TLR4 |
|
|
| T6738 |
24671-24676 |
Protein |
denotes |
MYD88 |
|
|
| T6739 |
24691-24695 |
Protein |
denotes |
TRIF |
|
|
| T6740 |
24724-24728 |
Protein |
denotes |
TLR3 |
|
|
| T6741 |
24729-24739 |
Positive_regulation |
denotes |
stimulated |
|
|
| T6742 |
24766-24770 |
Protein |
denotes |
TRIF |
|
|
| T6743 |
24862-24869 |
Protein |
denotes |
Sharpin |
|
|
| T6744 |
24870-24878 |
Negative_regulation |
denotes |
mutation |
|
|
| T6745 |
24970-24974 |
Protein |
denotes |
RIP1 |
|
|
| T6746 |
24979-24984 |
Protein |
denotes |
TRAF6 |
|
|
| T6747 |
25024-25031 |
Protein |
denotes |
SHARPIN |
|
|
| T6748 |
25032-25041 |
Binding |
denotes |
interacts |
|
|
| T6749 |
25047-25051 |
Protein |
denotes |
HOIP |
|
|
| T6750 |
25071-25077 |
Positive_regulation |
denotes |
exerts |
|
|
| T6751 |
25071-25077 |
Positive_regulation |
denotes |
exerts |
|
|
| T6752 |
25082-25120 |
Ubiquitination |
denotes |
linear-ubiquitin-chain-ligase activity |
|
|
| T6753 |
25082-25120 |
Ubiquitination |
denotes |
linear-ubiquitin-chain-ligase activity |
|
|
| T6754 |
25148-25152 |
Protein |
denotes |
RIP1 |
|
|
| T6755 |
25157-25161 |
Protein |
denotes |
NEMO |
|
|
| T6756 |
25196-25200 |
Protein |
denotes |
TNFα |
|
|
| T6757 |
25234-25241 |
Protein |
denotes |
Sharpin |
|
|
| T6758 |
25242-25255 |
Negative_regulation |
denotes |
null mutation |
|
|
| T6759 |
25256-25264 |
Negative_regulation |
denotes |
disrupts |
|
|
| T6760 |
25256-25264 |
Negative_regulation |
denotes |
disrupts |
|
|
| T6761 |
25310-25314 |
Protein |
denotes |
TNFα |
|
|
| T6762 |
25478-25485 |
Protein |
denotes |
SHARPIN |
|
|
| T6763 |
25599-25606 |
Protein |
denotes |
SHARPIN |
|
|
| T6764 |
25728-25735 |
Protein |
denotes |
Sharpin |
|
|
| T6765 |
25736-25745 |
Negative_regulation |
denotes |
deficient |
|
|
| T9628 |
26835-26842 |
Protein |
denotes |
Sharpin |
|
|
| T9953 |
27233-27240 |
Protein |
denotes |
Sharpin |
|
|
| T9954 |
27433-27440 |
Protein |
denotes |
Sharpin |
|
|
| T9955 |
27546-27553 |
Gene_expression |
denotes |
express |
|
|
| T9956 |
27566-27573 |
Protein |
denotes |
SHARPIN |
|
|
| T9957 |
27705-27712 |
Protein |
denotes |
SHARPIN |
|
|
| T9958 |
27896-27903 |
Protein |
denotes |
SHARPIN |
|
|
| T9959 |
27904-27914 |
Gene_expression |
denotes |
expression |
|
true |
| T10948 |
29926-29935 |
Gene_expression |
denotes |
secretion |
|
true |
| T10949 |
29926-29935 |
Gene_expression |
denotes |
secretion |
|
true |
| T10950 |
29926-29935 |
Gene_expression |
denotes |
secretion |
|
true |
| T10951 |
29926-29935 |
Gene_expression |
denotes |
secretion |
|
true |
| T10952 |
29939-29943 |
Protein |
denotes |
IFNγ |
|
|
| T10953 |
29945-29948 |
Protein |
denotes |
IL4 |
|
|
| T10954 |
29950-29953 |
Protein |
denotes |
IL2 |
|
|
| T10955 |
29959-29964 |
Protein |
denotes |
IL17A |
|
|
| T10956 |
30173-30183 |
Gene_expression |
denotes |
production |
true |
|
| T10957 |
30173-30183 |
Gene_expression |
denotes |
production |
true |
|
| T10958 |
30173-30183 |
Gene_expression |
denotes |
production |
true |
|
| T10959 |
30173-30183 |
Gene_expression |
denotes |
production |
true |
|
| T11335 |
30489-30499 |
Transcription |
denotes |
expression |
|
true |
| T11336 |
30489-30499 |
Transcription |
denotes |
expression |
|
true |
| T11337 |
30489-30499 |
Transcription |
denotes |
expression |
|
true |
| T11338 |
30489-30499 |
Transcription |
denotes |
expression |
|
true |
| T11339 |
30503-30506 |
Protein |
denotes |
Il6 |
|
|
| T11340 |
30508-30515 |
Protein |
denotes |
Il12p40 |
|
|
| T11341 |
30517-30522 |
Protein |
denotes |
Gmcsf |
|
|
| T11342 |
30528-30535 |
Protein |
denotes |
Sharpin |
|
|
| T11343 |
30856-30883 |
Protein |
denotes |
M-MLV Reverse Transcriptase |
|
|
| T11344 |
31218-31222 |
Protein |
denotes |
Actb |
|
|
| T11345 |
31224-31227 |
Protein |
denotes |
IL6 |
|
|
| T11346 |
31229-31236 |
Protein |
denotes |
IL12p40 |
|
|
| T11347 |
31238-31242 |
Protein |
denotes |
Ifnβ |
|
|
| T11348 |
31244-31249 |
Protein |
denotes |
Gmcsf |
|
|
| T11349 |
31255-31262 |
Protein |
denotes |
Sharpin |
|
|
| T11350 |
31370-31377 |
Protein |
denotes |
β-actin |
|
|
| T12082 |
31933-31940 |
Protein |
denotes |
SHARPIN |
|
|
| T12372 |
32776-32780 |
Protein |
denotes |
IKK1 |
|
|
| T12373 |
32781-32782 |
Protein |
denotes |
2 |
|
|
| T12374 |
32793-32797 |
Protein |
denotes |
IκBα |
|
|
| T12375 |
32807-32811 |
Protein |
denotes |
IκBα |
|
|
| T12376 |
32823-32827 |
Protein |
denotes |
TBK1 |
|
|
| T12377 |
32866-32870 |
Protein |
denotes |
ERK1 |
|
|
| T12378 |
32871-32872 |
Protein |
denotes |
2 |
|
|
| T12379 |
32886-32890 |
Protein |
denotes |
ERK1 |
|
|
| T12380 |
32891-32892 |
Protein |
denotes |
2 |
|
|
| T12381 |
32902-32912 |
Protein |
denotes |
Beta-actin |
|
|
| R10555 |
T12758 |
T12757 |
themeOf |
Sharpin,mRNA level |
| R10556 |
T12760 |
T12762 |
themeOf |
SHARPIN,localized |
| R10557 |
T12761 |
T12762 |
locationOf |
cytoplasm,localized |
| R11006 |
T13263 |
T13264 |
themeOf |
Sharpin,mutation |
| R11899 |
T14252 |
T14251 |
themeOf |
Il12p40,expression |
| R11900 |
T14253 |
T14250 |
themeOf |
Il6,expression |
| R11901 |
T14254 |
T14249 |
themeOf |
Gmcsf,expression |
| R11902 |
T14255 |
T14248 |
themeOf |
Ifnb,expression |
| R12179 |
T14567 |
T14570 |
themeOf |
TLR4,expression |
| R12180 |
T14568 |
T14569 |
themeOf |
MD2,expression |
| R12181 |
T14569 |
T14566 |
themeOf |
expression,Normal |
| R12182 |
T14570 |
T14565 |
themeOf |
expression,Normal |
| R12183 |
T14573 |
T14574 |
themeOf |
IL10,secretion |
| R12184 |
T14574 |
T14571 |
themeOf |
secretion,decreased |
| R12185 |
T14575 |
T14576 |
themeOf |
A20,expression |
| R12186 |
T14576 |
T14572 |
themeOf |
expression,decreased |
| R12187 |
T14579 |
T14578 |
themeOf |
A20,production |
| R12800 |
T15328 |
T15327 |
themeOf |
IFNγ,secretion |
| R12801 |
T15328 |
T15331 |
themeOf |
IFNγ,production |
| R12802 |
T15329 |
T15325 |
themeOf |
IL4,secretion |
| R12803 |
T15329 |
T15332 |
themeOf |
IL4,production |
| R12804 |
T15330 |
T15333 |
themeOf |
IL2,production |
| R12805 |
T15330 |
T15326 |
themeOf |
IL2,secretion |
| R1799 |
T2205 |
T2204 |
themeOf |
Sharpin,mutations |
| R1800 |
T2207 |
T2206 |
themeOf |
Sharpin,expression |
| R1801 |
T2208 |
T2209 |
themeOf |
Sharpin,present |
| R1802 |
T2209 |
T2210 |
themeOf |
present,decreased |
| R1803 |
T2212 |
T2211 |
themeOf |
Sharpin,reduction |
| R1804 |
T2214 |
T2215 |
locationOf |
cytoplasmic,localization |
| R1805 |
T2216 |
T2215 |
themeOf |
SHARPIN,localization |
| R2686 |
T3243 |
T3242 |
themeOf |
increased,resulted |
| R2687 |
T3244 |
T3259 |
themeOf |
expression,increased |
| R2688 |
T3245 |
T3261 |
themeOf |
expression,increased |
| R2689 |
T3246 |
T3243 |
themeOf |
expression,increased |
| R2690 |
T3248 |
T3247 |
themeOf |
expression,difference |
| R2691 |
T3250 |
T3249 |
themeOf |
expression,difference |
| R2692 |
T3253 |
T3251 |
themeOf |
expression,difference |
| R2693 |
T3259 |
T3258 |
themeOf |
increased,resulted |
| R2694 |
T3261 |
T3260 |
themeOf |
increased,resulted |
| R2695 |
T3262 |
T3241 |
themeOf |
Sharpin,mutation |
| R2696 |
T3267 |
T3256 |
themeOf |
TLR3,ligand |
| R2697 |
T3268 |
T3257 |
themeOf |
TLR4,ligand |
| R2698 |
T3269 |
T3244 |
themeOf |
CD40,expression |
| R2699 |
T3269 |
T3248 |
themeOf |
CD40,expression |
| R2700 |
T3270 |
T3245 |
themeOf |
CD80,expression |
| R2701 |
T3270 |
T3250 |
themeOf |
CD80,expression |
| R2702 |
T3271 |
T3246 |
themeOf |
CD86,expression |
| R2703 |
T3271 |
T3253 |
themeOf |
CD86,expression |
| R2704 |
T3272 |
T3254 |
themeOf |
SHARPIN,deficiency |
| R2705 |
T3278 |
T3252 |
themeOf |
SHARPIN,deficiency |
| R2706 |
T3279 |
T3255 |
themeOf |
Sharpin,mutation |
| R3126 |
T3807 |
T3806 |
themeOf |
secretion,resulted |
| R3127 |
T3808 |
T3805 |
themeOf |
secretion,resulted |
| R3128 |
T3809 |
T3808 |
themeOf |
IL6,secretion |
| R3129 |
T3809 |
T3811 |
themeOf |
IL6,produced |
| R3130 |
T3810 |
T3807 |
themeOf |
GMCSF,secretion |
| R3131 |
T3810 |
T3812 |
themeOf |
GMCSF,produced |
| R3132 |
T3811 |
T3813 |
themeOf |
produced,less |
| R3133 |
T3812 |
T3814 |
themeOf |
produced,less |
| R3134 |
T3815 |
T3816 |
themeOf |
Sharpin,deficient |
| R35 |
T93 |
T88 |
themeOf |
secretion,reduced |
| R3595 |
T4413 |
T4412 |
equivalentTo |
MD2,myeloid differentiation factor 2 |
| R3596 |
T4414 |
T4412 |
equivalentTo |
LY96,myeloid differentiation factor 2 |
| R3597 |
T4418 |
T4416 |
themeOf |
CD14,expression |
| R3598 |
T4419 |
T4417 |
themeOf |
TLR4,expression |
| R3599 |
T4420 |
T4415 |
themeOf |
MD2,expression |
| R36 |
T94 |
T90 |
themeOf |
IL6,transcription |
| R3600 |
T4422 |
T4421 |
themeOf |
IL10,secretion |
| R3601 |
T4424 |
T4423 |
themeOf |
levels,lower |
| R3602 |
T4425 |
T4424 |
themeOf |
IL10,levels |
| R3603 |
T4428 |
T4427 |
themeOf |
expression,Increased |
| R3604 |
T4429 |
T4428 |
themeOf |
A20,expression |
| R3605 |
T4430 |
T4432 |
themeOf |
transcript level,lower |
| R3606 |
T4431 |
T4430 |
themeOf |
A20,transcript level |
| R3607 |
T4434 |
T4433 |
themeOf |
A20,overexpression |
| R3608 |
T4441 |
T4442 |
themeOf |
Sharpin,deficient |
| R3609 |
T4447 |
T4446 |
themeOf |
phosphorylation,allowing |
| R3610 |
T4449 |
T4445 |
themeOf |
degradation,allowing |
| R3611 |
T4449 |
T4448 |
themeOf |
degradation,mediated |
| R3612 |
T4450 |
T4447 |
themeOf |
IκBα,phosphorylation |
| R3613 |
T4450 |
T4449 |
themeOf |
IκBα,degradation |
| R3614 |
T4451 |
T4460 |
themeOf |
phosphorylated,decreased |
| R3615 |
T4452 |
T4462 |
themeOf |
phosphorylated,decreased |
| R3616 |
T4453 |
T4461 |
themeOf |
phosphorylated,decreased |
| R3617 |
T4454 |
T4452 |
themeOf |
IKK1,phosphorylated |
| R3618 |
T4455 |
T4451 |
themeOf |
2,phosphorylated |
| R3619 |
T4458 |
T4453 |
themeOf |
IκBα,phosphorylated |
| R3620 |
T4463 |
T4468 |
themeOf |
TBK1,phosphorylation |
| R3621 |
T4464 |
T4466 |
themeOf |
ERK1,phosphorylation |
| R3622 |
T4465 |
T4467 |
themeOf |
2,phosphorylation |
| R3623 |
T4470 |
T4469 |
themeOf |
SHARPIN,absence |
| R37 |
T94 |
T93 |
themeOf |
IL6,secretion |
| R38 |
T95 |
T91 |
themeOf |
GMCSF,transcription |
| R39 |
T95 |
T92 |
themeOf |
GMCSF,secretion |
| R40 |
T98 |
T96 |
equivalentTo |
ERK1,MAPK1 |
| R41 |
T99 |
T97 |
equivalentTo |
2,3 |
| R42 |
T106 |
T105 |
themeOf |
Sharpin,loss |
| R4633 |
T5790 |
T5789 |
themeOf |
SHARPIN,absence |
| R4634 |
T5792 |
T5793 |
themeOf |
IFNγ,production |
| R4635 |
T5793 |
T5791 |
themeOf |
production,elicited |
| R4636 |
T5794 |
T5796 |
themeOf |
concentration,lower |
| R4637 |
T5795 |
T5794 |
themeOf |
IFNγ,concentration |
| R4638 |
T5797 |
T5800 |
themeOf |
TLR3,agonists |
| R4639 |
T5798 |
T5799 |
themeOf |
4,agonists |
| R4640 |
T5801 |
T5802 |
themeOf |
TLR2,ligand |
| R4641 |
T5803 |
T5802 |
themeOf |
Pam3CYS,ligand |
| R4642 |
T5804 |
T5805 |
causeOf |
Pam3CYS,induced |
| R4643 |
T5806 |
T5807 |
themeOf |
IFNγ,production |
| R4644 |
T5807 |
T5805 |
themeOf |
production,induced |
| R4645 |
T5810 |
T5811 |
themeOf |
IL4,produced |
| R4646 |
T5812 |
T5814 |
themeOf |
production,following |
| R4647 |
T5813 |
T5812 |
themeOf |
IL17A,production |
| R4648 |
T5815 |
T5816 |
themeOf |
IL2,production |
| R4649 |
T5817 |
T5818 |
themeOf |
induced,more |
| R4650 |
T5819 |
T5817 |
themeOf |
IL2,induced |
| R5370 |
T6684 |
T6683 |
themeOf |
Sharpin,null mutations |
| R5371 |
T6686 |
T6685 |
themeOf |
SHARPIN,loss |
| R5372 |
T6687 |
T6688 |
themeOf |
SHARPIN,disruption |
| R5373 |
T6691 |
T6690 |
themeOf |
TNF,deletion |
| R5374 |
T6693 |
T6692 |
themeOf |
SHARPIN,deficiency |
| R5375 |
T6694 |
T6695 |
themeOf |
HMGB1,recognized |
| R5376 |
T6696 |
T6695 |
themeOf |
TLR2,recognized |
| R5377 |
T6698 |
T6701 |
themeOf |
IL12P35,deficient |
| R5378 |
T6699 |
T6700 |
themeOf |
IL12P40,deficient |
| R5379 |
T6703 |
T6712 |
themeOf |
activation,was not |
| R5380 |
T6704 |
T6714 |
themeOf |
activation,was not |
| R5381 |
T6705 |
T6711 |
themeOf |
activation,was not |
| R5382 |
T6706 |
T6713 |
themeOf |
activation,was not |
| R5383 |
T6707 |
T6706 |
themeOf |
TBK1,activation |
| R5384 |
T6708 |
T6705 |
themeOf |
IRF3,activation |
| R5385 |
T6709 |
T6703 |
themeOf |
ERK1,activation |
| R5386 |
T6710 |
T6704 |
themeOf |
2,activation |
| R5387 |
T6719 |
T6718 |
themeOf |
Sharpin,deletion |
| R5388 |
T6722 |
T6723 |
themeOf |
Sharpin,expression |
| R5389 |
T6723 |
T6721 |
themeOf |
expression,absence |
| R5390 |
T6726 |
T6727 |
themeOf |
SHARPIN,deficient |
| R5391 |
T6730 |
T6731 |
themeOf |
Sharpin,mutation |
| R5392 |
T6734 |
T6732 |
themeOf |
TLR4,engage |
| R5393 |
T6735 |
T6733 |
themeOf |
TLR3,engage |
| R5394 |
T6737 |
T6736 |
themeOf |
TLR4,engages |
| R5395 |
T6740 |
T6741 |
themeOf |
TLR3,stimulated |
| R5396 |
T6743 |
T6744 |
themeOf |
Sharpin,mutation |
| R5397 |
T6747 |
T6748 |
themeOf |
SHARPIN,interacts |
| R5398 |
T6747 |
T6752 |
causeOf |
SHARPIN,linear-ubiquitin-chain-ligase activity |
| R5399 |
T6747 |
T6753 |
causeOf |
SHARPIN,linear-ubiquitin-chain-ligase activity |
| R5400 |
T6749 |
T6748 |
themeOf |
HOIP,interacts |
| R5401 |
T6752 |
T6751 |
themeOf |
linear-ubiquitin-chain-ligase activity,exerts |
| R5402 |
T6752 |
T6759 |
themeOf |
linear-ubiquitin-chain-ligase activity,disrupts |
| R5403 |
T6753 |
T6750 |
themeOf |
linear-ubiquitin-chain-ligase activity,exerts |
| R5404 |
T6753 |
T6760 |
themeOf |
linear-ubiquitin-chain-ligase activity,disrupts |
| R5405 |
T6754 |
T6752 |
themeOf |
RIP1,linear-ubiquitin-chain-ligase activity |
| R5406 |
T6755 |
T6753 |
themeOf |
NEMO,linear-ubiquitin-chain-ligase activity |
| R5407 |
T6757 |
T6758 |
themeOf |
Sharpin,null mutation |
| R5408 |
T6758 |
T6759 |
causeOf |
null mutation,disrupts |
| R5409 |
T6758 |
T6760 |
causeOf |
null mutation,disrupts |
| R5410 |
T6764 |
T6765 |
themeOf |
Sharpin,deficient |
| R671 |
T73 |
T72 |
themeOf |
Sharpin,mutations |
| R672 |
T74 |
T73 |
equivalentTo |
SHANK-associated RH domain-interacting protein,Sharpin |
| R673 |
T75 |
T73 |
equivalentTo |
Rbckl1,Sharpin |
| R674 |
T76 |
T73 |
equivalentTo |
Sipl1,Sharpin |
| R675 |
T77 |
T78 |
themeOf |
SHARPIN,deficient |
| R676 |
T79 |
T80 |
themeOf |
SHARPIN,deficiency |
| R677 |
T84 |
T85 |
themeOf |
SHARPIN,deficient |
| R678 |
T85 |
T87 |
causeOf |
deficient,reduced |
| R679 |
T85 |
T89 |
causeOf |
deficient,reduced |
| R680 |
T85 |
T88 |
causeOf |
deficient,reduced |
| R681 |
T85 |
T86 |
causeOf |
deficient,reduced |
| R682 |
T90 |
T87 |
themeOf |
transcription,reduced |
| R683 |
T91 |
T89 |
themeOf |
transcription,reduced |
| R684 |
T92 |
T86 |
themeOf |
secretion,reduced |
| R740 |
T950 |
T951 |
themeOf |
SHARPIN,expressed |
| R741 |
T952 |
T955 |
causeOf |
recessive mutations,resulting |
| R742 |
T952 |
T954 |
causeOf |
recessive mutations,resulting |
| R743 |
T953 |
T958 |
themeOf |
Sharpin,absence |
| R744 |
T953 |
T957 |
themeOf |
Sharpin,synthesis |
| R745 |
T953 |
T952 |
themeOf |
Sharpin,recessive mutations |
| R746 |
T956 |
T954 |
themeOf |
termination,resulting |
| R747 |
T957 |
T956 |
themeOf |
synthesis,termination |
| R748 |
T958 |
T955 |
themeOf |
absence,resulting |
| R749 |
T960 |
T959 |
themeOf |
secretion,decreased |
| R750 |
T961 |
T960 |
themeOf |
IFNγ,secretion |
| R751 |
T963 |
T962 |
themeOf |
IL5,Neutralization |
| R752 |
T964 |
T965 |
themeOf |
IL5,deficient |
| R753 |
T968 |
T969 |
themeOf |
SHARPIN,deficient |
| R754 |
T971 |
T972 |
themeOf |
SHARPIN,deficient |
| R755 |
T974 |
T973 |
themeOf |
SHARPIN,lack |
| R756 |
T976 |
T977 |
themeOf |
SHARPIN,deficient |
| R8182 |
T9956 |
T9955 |
themeOf |
SHARPIN,express |
| R8183 |
T9958 |
T9959 |
themeOf |
SHARPIN,expression |
| R9073 |
T10952 |
T10956 |
themeOf |
IFNγ,production |
| R9074 |
T10952 |
T10951 |
themeOf |
IFNγ,secretion |
| R9075 |
T10953 |
T10957 |
themeOf |
IL4,production |
| R9076 |
T10953 |
T10950 |
themeOf |
IL4,secretion |
| R9077 |
T10954 |
T10958 |
themeOf |
IL2,production |
| R9078 |
T10954 |
T10948 |
themeOf |
IL2,secretion |
| R9079 |
T10955 |
T10959 |
themeOf |
IL17A,production |
| R9080 |
T10955 |
T10949 |
themeOf |
IL17A,secretion |
| R9392 |
T11339 |
T11338 |
themeOf |
Il6,expression |
| R9393 |
T11340 |
T11337 |
themeOf |
Il12p40,expression |
| R9394 |
T11341 |
T11336 |
themeOf |
Gmcsf,expression |
| R9395 |
T11342 |
T11335 |
themeOf |
Sharpin,expression |
