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PubMed:8997164 / 60-1098 JSONTXT

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Id Subject Object Predicate Lexical cue
T2 0-1038 Paragraph denotes Recent studies in man and animal models have demonstrated that TCR-gamma delta-bearing T cells (gamma delta T cells) are activated by mycobacteria and accumulate in the sites of mycobacterial infection. Although the function of gamma delta T cells remains unclear, some data suggest a potential role for these cells in the granulomatous immune response. To address the presence of gamma delta T cells within the BCG granulomas, we have characterized the TCR phenotype of T-lymphocytes present in the BCG granulomatous lesion immunohistochemically using a monoclonal antibody to TCR delta 1 and others. Fairly large numbers of gamma delta T cells were located at the periphery of the BCG granulomas without necrosis and most of them also expressed CD8. However, gamma delta T cells were rarely present in the granulomas with central caseous necrosis, calcification and fibrotic changes. With these results, it might be speculated that the CD8+ gamma delta T lymphocytes participate in the BCG granuloma formation mainly in the early stage.
T7 18-21 Habitat denotes man
T8 26-39 Habitat denotes animal models
T9 63-94 Habitat denotes TCR-gamma delta-bearing T cells
T10 96-115 Habitat denotes gamma delta T cells
T11 134-146 Bacteria denotes mycobacteria
T12 178-191 Bacteria denotes mycobacterial
T13 228-247 Habitat denotes gamma delta T cells
T14 310-315 Habitat denotes cells
T15 323-336 Habitat denotes granulomatous
T16 381-400 Habitat denotes gamma delta T cells
T18 412-415 Bacteria denotes BCG
T17 412-426 Habitat denotes BCG granulomas
T19 471-484 Habitat denotes T-lymphocytes
T21 500-503 Bacteria denotes BCG
T20 500-524 Habitat denotes BCG granulomatous lesion
T22 504-517 Habitat denotes granulomatous
T23 626-645 Habitat denotes gamma delta T cells
T25 683-686 Bacteria denotes BCG
T24 683-714 Habitat denotes BCG granulomas without necrosis
T26 761-780 Habitat denotes gamma delta T cells
T27 808-884 Habitat denotes granulomas with central caseous necrosis, calcification and fibrotic changes
T28 938-968 Habitat denotes CD8+ gamma delta T lymphocytes
T30 988-991 Bacteria denotes BCG
T29 988-1001 Habitat denotes BCG granuloma