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PubMed:8997164 JSONTXT 2 Projects

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Id Subject Object Predicate Lexical cue
T3 0-25 Habitat denotes Gamma/delta T lymphocytes
T1 0-59 Title denotes Gamma/delta T lymphocytes in the BCG granulomatous lesions.
T5 33-36 Bacteria denotes BCG
T4 33-58 Habitat denotes BCG granulomatous lesions
T6 37-50 Habitat denotes granulomatous
T2 60-1098 Paragraph denotes Recent studies in man and animal models have demonstrated that TCR-gamma delta-bearing T cells (gamma delta T cells) are activated by mycobacteria and accumulate in the sites of mycobacterial infection. Although the function of gamma delta T cells remains unclear, some data suggest a potential role for these cells in the granulomatous immune response. To address the presence of gamma delta T cells within the BCG granulomas, we have characterized the TCR phenotype of T-lymphocytes present in the BCG granulomatous lesion immunohistochemically using a monoclonal antibody to TCR delta 1 and others. Fairly large numbers of gamma delta T cells were located at the periphery of the BCG granulomas without necrosis and most of them also expressed CD8. However, gamma delta T cells were rarely present in the granulomas with central caseous necrosis, calcification and fibrotic changes. With these results, it might be speculated that the CD8+ gamma delta T lymphocytes participate in the BCG granuloma formation mainly in the early stage.
T7 78-81 Habitat denotes man
T8 86-99 Habitat denotes animal models
T9 123-154 Habitat denotes TCR-gamma delta-bearing T cells
T10 156-175 Habitat denotes gamma delta T cells
T11 194-206 Bacteria denotes mycobacteria
T12 238-251 Bacteria denotes mycobacterial
T13 288-307 Habitat denotes gamma delta T cells
T14 370-375 Habitat denotes cells
T15 383-396 Habitat denotes granulomatous
T16 441-460 Habitat denotes gamma delta T cells
T18 472-475 Bacteria denotes BCG
T17 472-486 Habitat denotes BCG granulomas
T19 531-544 Habitat denotes T-lymphocytes
T21 560-563 Bacteria denotes BCG
T20 560-584 Habitat denotes BCG granulomatous lesion
T22 564-577 Habitat denotes granulomatous
T23 686-705 Habitat denotes gamma delta T cells
T25 743-746 Bacteria denotes BCG
T24 743-774 Habitat denotes BCG granulomas without necrosis
T26 821-840 Habitat denotes gamma delta T cells
T27 868-944 Habitat denotes granulomas with central caseous necrosis, calcification and fibrotic changes
T28 998-1028 Habitat denotes CD8+ gamma delta T lymphocytes
T30 1048-1051 Bacteria denotes BCG
T29 1048-1061 Habitat denotes BCG granuloma