bionlp-ost-19-BB-kb-ner-train  

BB-kb+ner@ldeleger:BB-kb+ner-20148898 JSONTXT

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Id Subject Object Predicate Lexical cue NCBI_Taxonomy OntoBiotope
T1 0-122 Title denotes The presence of professional phagocytes dictates the number of host cells targeted for Yop translocation during infection.
T3 16-39 Habitat denotes professional phagocytes OBT:000801
T4 63-73 Habitat denotes host cells OBT:000061
T5 123-141 Phenotype denotes Type III secretion OBT:000019
T2 123-1600 Paragraph denotes Type III secretion systems deliver effector proteins from Gram-negative bacterial pathogens into host cells, where they disarm host defences, allowing the pathogens to establish infection. Although Yersinia pseudotuberculosis delivers its effector proteins, called Yops, into numerous cell types grown in culture, we show that during infection Y. pseudotuberculosis selectively targets Yops to professional phagocytes in Peyer's patches, mesenteric lymph nodes and spleen, although it colocalizes with B and T cells as well as professional phagocytes. Strikingly, in the absence of neutrophils, the number of cells with translocated Yops was significantly reduced although the bacterial loads were similar, indicating that Y. pseudotuberculosis did not arbitrarily deliver Yops to the available cells. Using isolated splenocytes, selective binding and selective targeting to professional phagocytes when bacteria were limiting was also observed, indicating that tissue architecture was not required for the tropism for professional phagocytes. In isolated splenocytes, YadA and Invasin increased the number of all cells types with translocated Yops, but professional phagocytes were still preferentially translocated with Yops in the absence of these adhesins. Together these results indicate that Y. pseudotuberculosis discriminates among cells it encounters during infection and selectively delivers Yops to phagocytes while refraining from translocation to other cell types.
T6 181-194 Phenotype denotes Gram-negative OBT:000648
T7 195-214 Phenotype denotes bacterial pathogens OBT:000375
T8 220-230 Habitat denotes host cells OBT:000061
T9 278-287 Phenotype denotes pathogens OBT:000375
T10 321-348 Microorganism denotes Yersinia pseudotuberculosis 633
T11 408-435 Habitat denotes cell types grown in culture OBT:000061
T12 467-488 Microorganism denotes Y. pseudotuberculosis 633
E1 467-488 Lives_In denotes Y. pseudotuberculosis
E2 467-488 Lives_In denotes Y. pseudotuberculosis
E3 467-488 Lives_In denotes Y. pseudotuberculosis
T13 517-559 Habitat denotes professional phagocytes in Peyer's patches OBT:000801
T14 544-559 Habitat denotes Peyer's patches OBT:001184|OBT:000334
T15 561-583 Habitat denotes mesenteric lymph nodes OBT:000718
T16 588-594 Habitat denotes spleen OBT:000890
T17-0 625-626 _FRAGMENT denotes B OBT:001623
T18 631-638 Habitat denotes T cells OBT:001623
T17-1 633-638 Habitat denotes cells
T19 650-673 Habitat denotes professional phagocytes OBT:000801
T20 705-716 Habitat denotes neutrophils OBT:003004
T21 732-760 Habitat denotes cells with translocated Yops OBT:000801
T22 846-867 Microorganism denotes Y. pseudotuberculosis 633
T23 918-923 Habitat denotes cells OBT:000801
T24 931-951 Habitat denotes isolated splenocytes OBT:000320
T25 998-1021 Habitat denotes professional phagocytes OBT:000801
T26 1142-1165 Habitat denotes professional phagocytes OBT:000801
T27 1170-1190 Habitat denotes isolated splenocytes OBT:000320
T28 1237-1242 Habitat denotes cells OBT:000801
T29 1277-1300 Habitat denotes professional phagocytes OBT:000801
T30 1421-1442 Microorganism denotes Y. pseudotuberculosis 633
T31 1463-1468 Habitat denotes cells OBT:000801
T32 1533-1543 Habitat denotes phagocytes OBT:000801
T33 1589-1593 Habitat denotes cell OBT:000801
C-T17-0 T17-1 T17-0 _lexicallyChainedTo cells,B
R1 E1 T12 Microorganism Y. pseudotuberculosis,Y. pseudotuberculosis
R2 E1 T15 Location Y. pseudotuberculosis,mesenteric lymph nodes
R3 E2 T12 Microorganism Y. pseudotuberculosis,Y. pseudotuberculosis
R4 E2 T16 Location Y. pseudotuberculosis,spleen
R5 E3 T12 Microorganism Y. pseudotuberculosis,Y. pseudotuberculosis
R6 E3 T14 Location Y. pseudotuberculosis,Peyer's patches