BB-kb+ner@ldeleger:BB-kb+ner-17237163
Annnotations
Below, discontinuous spans are shown in the chain model. You can change it to the bag model.
| Id | Subject | Object | Predicate | Lexical cue | NCBI_Taxonomy | OntoBiotope |
|---|---|---|---|---|---|---|
| T3 | 0-14 | Phenotype | denotes | Quorum-sensing | OBT:000143 | |
| T1 | 0-86 | Title | denotes | Quorum-sensing regulation of adhesion in Serratia marcescens MG1 is surface dependent. | ||
| T4 | 29-37 | Phenotype | denotes | adhesion | OBT:000029 | |
| T5 | 41-64 | Microorganism | denotes | Serratia marcescens MG1 | 615 | |
| E1 | 41-64 | Exhibits | denotes | Serratia marcescens MG1 | ||
| E2 | 41-64 | Exhibits | denotes | Serratia marcescens MG1 | ||
| T6 | 87-106 | Microorganism | denotes | Serratia marcescens | 615 | |
| E3 | 87-106 | Lives_In | denotes | Serratia marcescens | ||
| E4 | 87-106 | Lives_In | denotes | Serratia marcescens | ||
| E5 | 87-106 | Lives_In | denotes | Serratia marcescens | ||
| E6 | 87-106 | Lives_In | denotes | Serratia marcescens | ||
| E7 | 87-106 | Lives_In | denotes | Serratia marcescens | ||
| E8 | 87-106 | Lives_In | denotes | Serratia marcescens | ||
| E9 | 87-106 | Lives_In | denotes | Serratia marcescens | ||
| E10 | 87-106 | Lives_In | denotes | Serratia marcescens | ||
| E11 | 87-106 | Lives_In | denotes | Serratia marcescens | ||
| E12 | 87-106 | Exhibits | denotes | Serratia marcescens | ||
| E13 | 87-106 | Exhibits | denotes | Serratia marcescens | ||
| E14 | 87-106 | Exhibits | denotes | Serratia marcescens | ||
| E15 | 87-106 | Exhibits | denotes | Serratia marcescens | ||
| E16 | 87-106 | Exhibits | denotes | Serratia marcescens | ||
| E17 | 87-106 | Exhibits | denotes | Serratia marcescens | ||
| E18 | 87-106 | Exhibits | denotes | Serratia marcescens | ||
| E19 | 87-106 | Exhibits | denotes | Serratia marcescens | ||
| E20 | 87-106 | Exhibits | denotes | Serratia marcescens | ||
| T2 | 87-1888 | Paragraph | denotes | Serratia marcescens is an opportunistic pathogen and a major cause of ocular infections. In previous studies of S. marcescens MG1, we showed that biofilm maturation and sloughing were regulated by N-acyl homoserine lactone (AHL)-based quorum sensing (QS). Because of the importance of adhesion in initiating biofilm formation and infection, the primary goal of this study was to determine whether QS is important in adhesion to both abiotic and biotic surfaces, as assessed by determining the degree of attachment to hydrophilic tissue culture plates and human corneal epithelial (HCE) cells. Our results demonstrate that while adhesion to the abiotic surface was AHL regulated, adhesion to the HCE cell biotic surface was not. Type I fimbriae were identified as the critical adhesin for non-QS-mediated attachment to the biotic HCE cell surface but played no role in adhesion to the abiotic surface. While we were not able to identify a single QS-regulated adhesin essential for attachment to the abiotic surface, four AHL-regulated genes involved in adhesion to the abiotic surface were identified. Interestingly, two of these genes, bsmA and bsmB, were also shown to be involved in adhesion to the biotic surface in a non-QS-controlled fashion. Therefore, the expression of these two genes appears to be cocontrolled by regulators other than the QS system for mediation of attachment to HCE cells. We also found that QS in S. marcescens regulates other potential cell surface adhesins, including exopolysaccharide and the outer membrane protein OmpX. We concluded that S. marcescens MG1 utilizes different regulatory systems and adhesins in attachment to biotic and abiotic surfaces and that QS is a main regulatory pathway in adhesion to an abiotic surface but not in adhesion to a biotic surface. | ||
| T7 | 113-135 | Phenotype | denotes | opportunistic pathogen | OBT:000776 | |
| T8 | 157-163 | Habitat | denotes | ocular | OBT:000627 | |
| T9 | 199-216 | Microorganism | denotes | S. marcescens MG1 | 615 | |
| E21 | 199-216 | Lives_In | denotes | S. marcescens MG1 | ||
| E22 | 199-216 | Exhibits | denotes | S. marcescens MG1 | ||
| E23 | 199-216 | Exhibits | denotes | S. marcescens MG1 | ||
| T10 | 233-240 | Habitat | denotes | biofilm | OBT:000054 | |
| T11 | 233-251 | Phenotype | denotes | biofilm maturation | OBT:001444 | |
| T12 | 284-336 | Phenotype | denotes | N-acyl homoserine lactone (AHL)-based quorum sensing | OBT:000143 | |
| T13 | 338-340 | Phenotype | denotes | QS | OBT:000143 | |
| T14 | 372-380 | Phenotype | denotes | adhesion | OBT:000029 | |
| T15 | 395-402 | Habitat | denotes | biofilm | OBT:000054 | |
| T16 | 395-412 | Phenotype | denotes | biofilm formation | OBT:001444 | |
| T17 | 484-486 | Phenotype | denotes | QS | OBT:000143 | |
| T18 | 503-511 | Phenotype | denotes | adhesion | OBT:000029 | |
| T19-0 | 520-527 | _FRAGMENT | denotes | abiotic | OBT:000007 | |
| T20 | 532-547 | Habitat | denotes | biotic surfaces | OBT:000007 | |
| T19-1 | 539-547 | Habitat | denotes | surfaces | ||
| T21 | 590-600 | Phenotype | denotes | attachment | OBT:000029 | |
| T23 | 604-630 | Habitat | denotes | hydrophilic tissue culture | OBT:000062 | |
| T22 | 604-637 | Habitat | denotes | hydrophilic tissue culture plates | OBT:000103 | |
| T25 | 642-647 | Habitat | denotes | human | OBT:002488 | |
| T24 | 642-678 | Habitat | denotes | human corneal epithelial (HCE) cells | OBT:000061 | |
| T26 | 648-655 | Habitat | denotes | corneal | OBT:000573 | |
| T27 | 656-666 | Habitat | denotes | epithelial | OBT:001091 | |
| T28 | 715-723 | Phenotype | denotes | adhesion | OBT:000029 | |
| T29 | 731-746 | Habitat | denotes | abiotic surface | OBT:000007 | |
| T30 | 766-774 | Phenotype | denotes | adhesion | OBT:000029 | |
| T31 | 782-790 | Habitat | denotes | HCE cell | OBT:000061 | |
| T32 | 782-805 | Habitat | denotes | HCE cell biotic surface | OBT:000062 | |
| T33 | 879-881 | Phenotype | denotes | QS | OBT:000143 | |
| T34 | 891-901 | Phenotype | denotes | attachment | OBT:000029 | |
| T35 | 909-932 | Habitat | denotes | biotic HCE cell surface | OBT:000062 | |
| T36 | 916-924 | Habitat | denotes | HCE cell | OBT:000061 | |
| T37 | 955-963 | Phenotype | denotes | adhesion | OBT:000029 | |
| T38 | 971-986 | Habitat | denotes | abiotic surface | OBT:000007 | |
| T39 | 1032-1034 | Phenotype | denotes | QS | OBT:000143 | |
| T40 | 1067-1077 | Phenotype | denotes | attachment | OBT:000029 | |
| T41 | 1085-1100 | Habitat | denotes | abiotic surface | OBT:000007 | |
| T42 | 1139-1147 | Phenotype | denotes | adhesion | OBT:000029 | |
| T43 | 1155-1170 | Habitat | denotes | abiotic surface | OBT:000007 | |
| T44 | 1272-1280 | Phenotype | denotes | adhesion | OBT:000029 | |
| T45 | 1288-1302 | Habitat | denotes | biotic surface | OBT:000062 | |
| T46 | 1312-1314 | Phenotype | denotes | QS | OBT:000143 | |
| T47 | 1436-1438 | Phenotype | denotes | QS | OBT:000143 | |
| T48 | 1463-1473 | Phenotype | denotes | attachment | OBT:000029 | |
| T49 | 1477-1486 | Habitat | denotes | HCE cells | OBT:000061 | |
| T50 | 1507-1509 | Phenotype | denotes | QS | OBT:000143 | |
| T51 | 1513-1526 | Microorganism | denotes | S. marcescens | 615 | |
| E24 | 1513-1526 | Exhibits | denotes | S. marcescens | ||
| T52 | 1659-1676 | Microorganism | denotes | S. marcescens MG1 | 615 | |
| E25 | 1659-1676 | Lives_In | denotes | S. marcescens MG1 | ||
| E26 | 1659-1676 | Lives_In | denotes | S. marcescens MG1 | ||
| E27 | 1659-1676 | Lives_In | denotes | S. marcescens MG1 | ||
| E28 | 1659-1676 | Lives_In | denotes | S. marcescens MG1 | ||
| E29 | 1659-1676 | Exhibits | denotes | S. marcescens MG1 | ||
| E30 | 1659-1676 | Exhibits | denotes | S. marcescens MG1 | ||
| E31 | 1659-1676 | Exhibits | denotes | S. marcescens MG1 | ||
| E32 | 1659-1676 | Exhibits | denotes | S. marcescens MG1 | ||
| T53 | 1731-1741 | Phenotype | denotes | attachment | OBT:000029 | |
| T54-0 | 1745-1751 | _FRAGMENT | denotes | biotic | OBT:000062 | |
| T55 | 1756-1772 | Habitat | denotes | abiotic surfaces | OBT:000007 | |
| T54-1 | 1764-1772 | Habitat | denotes | surfaces | ||
| T56 | 1782-1784 | Phenotype | denotes | QS | OBT:000143 | |
| T57 | 1817-1825 | Phenotype | denotes | adhesion | OBT:000029 | |
| T58 | 1832-1847 | Habitat | denotes | abiotic surface | OBT:000007 | |
| T59 | 1859-1867 | Phenotype | denotes | adhesion | OBT:000029 | |
| T60 | 1873-1887 | Habitat | denotes | biotic surface | OBT:000062 | |
| C-T19-0 | T19-1 | T19-0 | _lexicallyChainedTo | surfaces,abiotic | ||
| C-T54-0 | T54-1 | T54-0 | _lexicallyChainedTo | surfaces,biotic | ||
| R1 | E1 | T5 | Microorganism | Serratia marcescens MG1,Serratia marcescens MG1 | ||
| R10 | E5 | T8 | Location | Serratia marcescens,ocular | ||
| R11 | E6 | T6 | Microorganism | Serratia marcescens,Serratia marcescens | ||
| R12 | E6 | T32 | Location | Serratia marcescens,HCE cell biotic surface | ||
| R13 | E7 | T6 | Microorganism | Serratia marcescens,Serratia marcescens | ||
| R14 | E7 | T45 | Location | Serratia marcescens,biotic surface | ||
| R15 | E8 | T6 | Microorganism | Serratia marcescens,Serratia marcescens | ||
| R16 | E8 | T43 | Location | Serratia marcescens,abiotic surface | ||
| R17 | E9 | T6 | Microorganism | Serratia marcescens,Serratia marcescens | ||
| R18 | E9 | T38 | Location | Serratia marcescens,abiotic surface | ||
| R19 | E10 | T6 | Microorganism | Serratia marcescens,Serratia marcescens | ||
| R2 | E1 | T3 | Property | Serratia marcescens MG1,Quorum-sensing | ||
| R20 | E10 | T41 | Location | Serratia marcescens,abiotic surface | ||
| R21 | E11 | T6 | Microorganism | Serratia marcescens,Serratia marcescens | ||
| R22 | E11 | T35 | Location | Serratia marcescens,biotic HCE cell surface | ||
| R23 | E12 | T6 | Microorganism | Serratia marcescens,Serratia marcescens | ||
| R24 | E12 | T37 | Property | Serratia marcescens,adhesion | ||
| R25 | E13 | T6 | Microorganism | Serratia marcescens,Serratia marcescens | ||
| R26 | E13 | T7 | Property | Serratia marcescens,opportunistic pathogen | ||
| R27 | E14 | T6 | Microorganism | Serratia marcescens,Serratia marcescens | ||
| R28 | E14 | T48 | Property | Serratia marcescens,attachment | ||
| R29 | E15 | T6 | Microorganism | Serratia marcescens,Serratia marcescens | ||
| R3 | E2 | T5 | Microorganism | Serratia marcescens MG1,Serratia marcescens MG1 | ||
| R30 | E15 | T40 | Property | Serratia marcescens,attachment | ||
| R31 | E16 | T6 | Microorganism | Serratia marcescens,Serratia marcescens | ||
| R32 | E16 | T34 | Property | Serratia marcescens,attachment | ||
| R33 | E17 | T6 | Microorganism | Serratia marcescens,Serratia marcescens | ||
| R34 | E17 | T30 | Property | Serratia marcescens,adhesion | ||
| R35 | E18 | T6 | Microorganism | Serratia marcescens,Serratia marcescens | ||
| R36 | E18 | T44 | Property | Serratia marcescens,adhesion | ||
| R37 | E19 | T6 | Microorganism | Serratia marcescens,Serratia marcescens | ||
| R38 | E19 | T28 | Property | Serratia marcescens,adhesion | ||
| R39 | E20 | T6 | Microorganism | Serratia marcescens,Serratia marcescens | ||
| R4 | E2 | T4 | Property | Serratia marcescens MG1,adhesion | ||
| R40 | E20 | T42 | Property | Serratia marcescens,adhesion | ||
| R41 | E21 | T9 | Microorganism | S. marcescens MG1,S. marcescens MG1 | ||
| R42 | E21 | T10 | Location | S. marcescens MG1,biofilm | ||
| R43 | E22 | T9 | Microorganism | S. marcescens MG1,S. marcescens MG1 | ||
| R44 | E22 | T11 | Property | S. marcescens MG1,biofilm maturation | ||
| R45 | E23 | T9 | Microorganism | S. marcescens MG1,S. marcescens MG1 | ||
| R46 | E23 | T12 | Property | S. marcescens MG1,N-acyl homoserine lactone (AHL)-based quorum sensing | ||
| R47 | E24 | T51 | Microorganism | S. marcescens,S. marcescens | ||
| R48 | E24 | T50 | Property | S. marcescens,QS | ||
| R49 | E25 | T52 | Microorganism | S. marcescens MG1,S. marcescens MG1 | ||
| R5 | E3 | T6 | Microorganism | Serratia marcescens,Serratia marcescens | ||
| R50 | E25 | T58 | Location | S. marcescens MG1,abiotic surface | ||
| R51 | E26 | T52 | Microorganism | S. marcescens MG1,S. marcescens MG1 | ||
| R52 | E26 | T55 | Location | S. marcescens MG1,abiotic surfaces | ||
| R53 | E27 | T52 | Microorganism | S. marcescens MG1,S. marcescens MG1 | ||
| R54 | E27 | T60 | Location | S. marcescens MG1,biotic surface | ||
| R55 | E28 | T52 | Microorganism | S. marcescens MG1,S. marcescens MG1 | ||
| R56 | E28 | T54-0 | Location | S. marcescens MG1,biotic | ||
| R57 | E29 | T52 | Microorganism | S. marcescens MG1,S. marcescens MG1 | ||
| R58 | E29 | T56 | Property | S. marcescens MG1,QS | ||
| R59 | E30 | T52 | Microorganism | S. marcescens MG1,S. marcescens MG1 | ||
| R6 | E3 | T29 | Location | Serratia marcescens,abiotic surface | ||
| R60 | E30 | T53 | Property | S. marcescens MG1,attachment | ||
| R61 | E31 | T52 | Microorganism | S. marcescens MG1,S. marcescens MG1 | ||
| R62 | E31 | T59 | Property | S. marcescens MG1,adhesion | ||
| R63 | E32 | T52 | Microorganism | S. marcescens MG1,S. marcescens MG1 | ||
| R64 | E32 | T57 | Property | S. marcescens MG1,adhesion | ||
| R7 | E4 | T6 | Microorganism | Serratia marcescens,Serratia marcescens | ||
| R8 | E4 | T49 | Location | Serratia marcescens,HCE cells | ||
| R9 | E5 | T6 | Microorganism | Serratia marcescens,Serratia marcescens |