UseCases_ArguminSci_Discourse  

PubMed:23231918 JSONTXT 10 Projects

Annnotations TAB TSV DIC JSON TextAE

Id Subject Object Predicate Lexical cue
T1 0-90 DRI_Background denotes Mutant LRRK2 elicits calcium imbalance and depletion of dendritic mitochondria in neurons.
T2 91-220 DRI_Approach denotes Mutations in the leucine-rich repeat kinase 2 (LRRK2) have been associated with familial and sporadic cases of Parkinson disease.
T3 221-412 DRI_Background denotes Mutant LRRK2 causes in vitro and in vivo neurite shortening, mediated in part by autophagy, and a parkinsonian phenotype in transgenic mice; however, the underlying mechanisms remain unclear.
T4 413-592 DRI_Background denotes Because mitochondrial content/function is essential for dendritic morphogenesis and maintenance, we investigated whether mutant LRRK2 affects mitochondrial homeostasis in neurons.
T5 593-633 DRI_Background denotes Mouse cortical neurons expressing either
T6 634-646 Token_Label.OUTSIDE denotes LRRK2 G2019S
T7 647-740 DRI_Background denotes or R1441C mutations exhibited autophagic degradation of mitochondria and dendrite shortening.
T8 741-841 DRI_Background denotes In addition, mutant LRRK2 altered the ability of the neurons to buffer intracellular calcium levels.
T9 842-982 DRI_Background denotes Either calcium chelators or inhibitors of voltage-gated L-type calcium channels prevented mitochondrial degradation and dendrite shortening.
T10 983-1115 DRI_Background denotes These data suggest that mutant LRRK2 causes a deficit in calcium homeostasis, leading to enhanced mitophagy and dendrite shortening.