SMAFIRA-Case-Studies-21494637  

Documents (103) JSON TSV

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PubMed 16269541 Parkinson's disease-associated mutations in leucine-rich repeat kinase 2 augment kinase activity. Mutations in the leucine-rich repeat kinase 2 gene (LRRK2) cause late-onset Parkinson's disease (PD) w 1.16 KB 2015-11-23 9 0
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PubMed 17388990 A common leucine-rich repeat kinase 2 gene mutation in familial and sporadic Parkinson's disease in Russia. A PARK8 form of Parkinson's disease (PD) is caused by a novel gene, leucine-rich repeat kina 1.41 KB 2020-01-29 12 0
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PubMed 17498648 Loss of LRRK2/PARK8 induces degeneration of dopaminergic neurons in Drosophila. Mutations in LRRK2/PARK8 are linked to autosomal dominant forms of Parkinson's disease, but the pathogenic mechanism of 1006 Bytes 2015-12-24 5 0
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PubMed 17623048 Leucine-rich repeat kinase 2 (LRRK2)/PARK8 possesses GTPase activity that is altered in familial Parkinson's disease R1441C/G mutants. Mutations in Leucine-rich repeat kinase 2 (LRRK2) are linked to t 1.7 KB 2015-12-24 11 0
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PubMed 18182054 Role of autophagy in G2019S-LRRK2-associated neurite shortening in differentiated SH-SY5Y cells. Neuritic retraction represents a prominent feature of the degenerative phenotype associated with mutati 1.8 KB 2020-01-21 9 0
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PubMed 18258746 A Drosophila model for LRRK2-linked parkinsonism. Mutations in the leucine-rich repeat kinase (LRRK2) gene cause late-onset autosomal dominant Parkinson's disease (PD) with pleiomorphic pathology. Pre 1.27 KB 2020-01-21 8 0
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PubMed 18634852 Expression of the LRRK2 gene in the midbrain dopaminergic neurons of the substantia nigra. A hallmark of Parkinson's disease (PD) is the progressive loss of the A9 midbrain dopaminergic (mDA) neurons 1.6 KB 2020-01-28 7 0
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PubMed 18805725 Genetic analysis for five LRRK2 mutations in a Sardinian parkinsonian population: importance of G2019S and R1441C mutations in sporadic Parkinson's disease patients. Mutations in the LRRK2 gene are th 1.51 KB 2020-01-29 10 0
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PubMed 19025767 Leucine-rich repeat kinase 2 (LRRK2): a key player in the pathogenesis of Parkinson's disease. Parkinson's disease (PD) is the most common neurodegenerative movement disorder, with a prevalence of mor 1.05 KB 2020-01-29 9 0
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PubMed 19545277 Leucine-rich repeat kinase 2 phosphorylates brain tubulin-beta isoforms and modulates microtubule stability--a point of convergence in parkinsonian neurodegeneration? Autosomal dominant mutations in l 1.56 KB 2020-01-22 9 0
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