PubMed_ArguminSci  

PubMed:31681295 JSONTXT 6 Projects

Annnotations TAB TSV DIC JSON TextAE

Id Subject Object Predicate Lexical cue
T1 102-213 DRI_Background denotes thogenic effect of mutant HTT (mHTT) which causes Huntington disease (HD) are not restricted to nervous system.
T2 214-290 DRI_Outcome denotes Such phenotypes include aberrant immune responses observed in the HD models.
T3 291-417 DRI_Challenge denotes However, it is still unclear how this immune dysregulation influences the innate immune response against pathogenic infection.
T4 418-607 DRI_Outcome denotes In the present study, we used transgenic Drosophila melanogaster expressing mutant HTT protein (mHTT) with hemocyte-specific drivers and examined the immune responses and hemocyte function.
T5 608-755 DRI_Outcome denotes We found that mHTT expression in the hemocytes did not affect fly viability, but the numbers of circulating hemocytes were significantly decreased.
T6 756-1006 DRI_Outcome denotes Consequently, we observed that the expression of mHTT in the hemocytes compromised the immune responses including clot formation and encapsulation which lead to the increased susceptibility to entomopathogenic nematode and parasitoid wasp infections.
T7 1007-1168 DRI_Outcome denotes In addition, mHTT expression in Drosophila macrophage-like S2 cells in vitro reduced ATP levels, phagocytic activity and the induction of antimicrobial peptides.
T8 1169-1301 DRI_Approach denotes Further effects observed in mHTT-expressing cells included the altered production of cytokines and activation of JAK/STAT signaling.
T9 1302-1460 DRI_Background denotes The present study shows that the expression of mHTT in Drosophila hemocytes causes deficient cellular and humoral immune responses against invading pathogens.
T10 1461-1550 DRI_Outcome denotes Our findings provide the insight into the pathogenic effects of mHTT in the immune cells.