| Id |
Subject |
Object |
Predicate |
Lexical cue |
| T1 |
75-176 |
DRI_Background |
denotes |
Tissue morphogenesis arises from coordinated changes in cell shape driven by actomyosin contractions. |
| T2 |
177-273 |
DRI_Background |
denotes |
Patterns of gene expression regionalize cell behaviours by controlling actomyosin contractility. |
| T3 |
274-380 |
DRI_Approach |
denotes |
Here we report two modes of control over Rho1 and myosin II (MyoII) activation in the Drosophila endoderm. |
| T4 |
381-521 |
DRI_Approach |
denotes |
First, Rho1-MyoII are induced in a spatially restricted primordium via localized transcription of the G-protein-coupled receptor ligand Fog. |
| T5 |
522-644 |
DRI_Background |
denotes |
Second, a tissue-scale wave of Rho1-MyoII activation and cell invagination progresses anteriorly away from the primordium. |
| T6 |
645-747 |
DRI_Approach |
denotes |
The wave does not require sustained gene transcription, and is not governed by regulated Fog delivery. |
| T7 |
748-862 |
DRI_Outcome |
denotes |
Instead, MyoII inhibition blocks Rho1 activation and propagation, revealing a mechanical feedback driven by MyoII. |
| T8 |
863-1064 |
DRI_Approach |
denotes |
We find that MyoII activation and invagination in each row of cells drives adhesion to the vitelline membrane mediated by integrins, apical spreading, MyoII activation and invagination in the next row. |
| T9 |
1065-1191 |
DRI_Background |
denotes |
Endoderm morphogenesis thus emerges from local transcriptional initiation and a mechanically driven cycle of cell deformation. |
