| Id |
Subject |
Object |
Predicate |
Lexical cue |
| T1 |
114-243 |
DRI_Background |
denotes |
Increasing evidence has shown that dysregulation of microRNA-621 (miR-621) is demonstrated to be associated with several cancers. |
| T2 |
244-313 |
DRI_Background |
denotes |
However, the role of miR-621 in bladder cancer (BCa) remains unclear. |
| T3 |
314-427 |
DRI_Approach |
denotes |
Herein, we aimed to study the expression pattern, biological function, and molecular mechanism of miR-621 in BCa. |
| T4 |
428-621 |
DRI_Outcome |
denotes |
First, we demonstrated that miR-621 was frequently downregulated in BCa tissues and cell lines compared with the adjacent normal BCa tissues and non-cancerous immortalized urothelial cell line. |
| T5 |
622-725 |
DRI_Outcome |
denotes |
In addition, the expression of miR-621 was negatively correlated with overall survival of BCa patients. |
| T6 |
726-829 |
DRI_Background |
denotes |
Functional experiments suggessted that miR-621 inhibited the proliferation and metastasis of BCa cells. |
| T7 |
830-1027 |
DRI_Background |
denotes |
Notably, dual-luciferase assay showed that miR-621 directly targeted the 3' UTR of TRIM29, which was frequently upregulated in BCa tissues and displayed inverse correlation with miR-621 expression. |
| T8 |
1028-1182 |
DRI_Outcome |
denotes |
Furthermore, we demonstrated that miR-621 inhibited the proliferation and metastasis of BCa cells via Wnt/β-catenin signaling pathway by targeting TRIM29. |
| T9 |
1183-1405 |
DRI_Outcome |
denotes |
Our study suggested that the miR-621/TRIM29 axis inhibits the proliferation and metastasis of BCa cells via Wnt/β-catenin signaling pathway and may have potential applications for development of BCa diagnosis or treatment. |
