PubMed_ArguminSci  

PubMed:28549065 JSONTXT 7 Projects

Annnotations TAB TSV DIC JSON TextAE

Id Subject Object Predicate Lexical cue
T1 116-322 DRI_Approach denotes Activation of the FOXO transcription factor DAF-16 by reduced insulin/IGF signaling (IIS) is considered to be beneficial in C. elegans due to its ability to extend lifespan and to enhance stress resistance.
T2 437-449 DRI_Background denotes In contrast,
T3 468-614 DRI_Background denotes causes a tumorous germline phenotype characterized by hyperproliferation of the germline stem cells and rupture of the adjacent basement membrane.
T4 615-702 DRI_Outcome denotes Here we show that cross-talk between DAF-16 and the transforming growth factor ß (TGFß)
T5 720-831 DRI_Outcome denotes protein (BMP) signaling pathway causes germline hyperplasia and results in disruption of the basement membrane.
T6 832-1020 DRI_Outcome denotes In addition to activating MADM/NRBP/hpo-11 gene alone, DAF-16 also directly interacts with both R-SMAD proteins SMA-2 and SMA-3 in the nucleus to regulate the expression of mTORC1 pathway.
T7 1021-1252 DRI_Background denotes Knocking-down of BMP genes or each of the four target genes in the hypodermis was sufficient to inhibit germline proliferation, indicating a cell-non-autonomously controlled regulation of stem cell proliferation by somatic tissues.
T8 1253-1394 DRI_Approach denotes We propose the existence of two antagonistic DAF-16/FOXO functions, a cell-proliferative somatic and an anti-proliferative germline activity.
T9 1395-1457 DRI_Background denotes Whereas germline hyperplasia under reduced IIS is inhibited by
T10 1482-1625 DRI_Background denotes , activation of somatic DAF-16 in the presence of active IIS promotes germline proliferation and eventually induces tumor-like germline growth.
T11 1626-1800 DRI_Outcome denotes In summary, our results suggest a novel pathway crosstalk of DAF-16 and TGF-ß/BMP that can modulate mTORC1 at the transcriptional level to cause stem-cell hyperproliferation.
T12 1801-1967 DRI_Challenge denotes Such cell-type specific differences may help explaining why human FOXO activity is considered to be tumor-suppressive in most contexts, but may become oncogenic, e.g.
T13 1968-2006 DRI_Background denotes in chronic and acute myeloid leukemia.