PubMed_ArguminSci  

PubMed:26365279 JSONTXT 7 Projects

Annnotations TAB TSV DIC JSON TextAE

Id Subject Object Predicate Lexical cue
T1 118-247 DRI_Challenge denotes Avian metapneumovirus (aMPV) is a pathogen with worldwide distribution, which can cause high economic losses in infected poultry.
T2 248-383 DRI_Background denotes aMPV mainly causes infection of the upper respiratory tract in both chickens and turkeys, although turkeys seem to be more susceptible.
T3 384-474 DRI_Background denotes Little is known about virus-host interactions at epithelial surfaces after aMPV infection.
T4 475-594 DRI_Background denotes Tracheal organ cultures (TOC) are a suitable model to investigate virus-host interaction in the respiratory epithelium.
T5 595-749 DRI_Approach denotes Therefore, we investigated virus replication rates and lesion development in chicken and turkey TOC after infection with a virulent aMPV subtype A strain.
T6 750-914 DRI_Background denotes Aspects of the innate immune response, such as interferon-α and inducible nitric oxide synthase mRNA expression, as well as virus-induced apoptosis were determined.
T7 915-1090 DRI_Outcome denotes The aMPV-replication rate was higher in turkey (TTOC) compared to chicken TOC (CTOC) (P < 0.05), providing circumstantial evidence that indeed turkeys may be more susceptible.
T8 1091-1276 DRI_Outcome denotes The interferon-α response was down-regulated from 2 to 144 hours post infection in both species compared to virus-free controls (P < 0.05); this was more significant for CTOC than TTOC.
T9 1277-1353 DRI_Background denotes Inducible nitric oxide synthase expression was significantly up-regulated in
T10 1375-1427 DRI_Background denotes and CTOC compared to virus-free controls (P < 0.05).
T11 1428-1626 DRI_Challenge denotes However, the results suggest that NO may play a different role in aMPV pathogenesis between turkeys and chickens as indicated by differences in apoptosis rate and lesion development between species.
T12 1627-1910 DRI_Outcome denotes Overall, our study reveals differences in innate immune response regulation and therefore may explain differences in aMPV - A replication rates between infected TTOC and CTOC, which subsequently lead to more severe clinical signs and a higher rate of secondary infections in turkeys.