PubMed_ArguminSci  

PubMed:26255059 JSONTXT 8 Projects

Annnotations TAB TSV DIC JSON TextAE

Id Subject Object Predicate Lexical cue
T1 197-326 DRI_Background denotes Ductal carcinoma in situ (DCIS) is a pre-invasive malignancy detected with an increasing frequency through screening mammography.
T2 327-481 DRI_Background denotes One of the primary aims of therapy is to prevent local recurrence, as in situ or as invasive carcinoma, the latter arising in half of the recurrent cases.
T3 482-603 DRI_Background denotes Reliable biomarkers predictive of its association with recurrence, particularly as invasive disease, are however lacking.
T4 604-933 DRI_Approach denotes In this study, we perform a meta-analysis of 26 studies which report somatic copy number aberrations (SCNAs) in 288 cases of 'pure' DCIS and 328 of DCIS associated with invasive carcinoma, along with additional unmatched cases of 145 invasive carcinoma of ductal/no special type (IDC) and 50 of atypical ductal hyperplasia (ADH).
T5 934-1102 DRI_Approach denotes SCNA frequencies across the genome were calculated at cytoband resolution (UCSC genome build 19) to maximally utilize the available information in published literature.
T6 1103-1246 DRI_Approach denotes Fisher's exact test was used to identify significant differences in the gain-loss distribution in each cytoband in different group comparisons.
T7 1247-1370 DRI_Outcome denotes We found synchronous DCIS to be at a more advanced stage of genetic aberrations than pure DCIS and was very similar to IDC.
T8 1371-1432 DRI_Approach denotes Differences in gains and losses in each disease process (i.e.
T9 1433-1676 DRI_Background denotes invasive or in situ) at each cytoband were used to infer evidence of selection and conservation for each cytoband and to define an evolutionary conservation scale (ECS) as a tool to identify and distinguish driver SCNA from the passenger SCNA.
T10 1677-1791 DRI_Outcome denotes Using ECS, we have identified aberrations that show evidence of selection from the early stages of neoplasia (i.e.
T11 1792-1946 DRI_Challenge denotes in ADH and pure DCIS) and persist in IDC; we postulate these to be driver aberrations and that their presence may predict progression to invasive disease.