PubMed_ArguminSci  

PubMed:25854766 JSONTXT 7 Projects

Annnotations TAB TSV DIC JSON TextAE

Id Subject Object Predicate Lexical cue
T1 147-274 DRI_Background denotes Doxorubicin (DOX) is an anthracycline antibiotic routinely used as a chemotherapeutic agent for the treatment of solid tumours.
T2 275-368 DRI_Background denotes However, DOX possesses an acute and cumulative cardiotoxicity due to free radical production.
T3 369-618 DRI_Background denotes The present study was designed to investigate the possible protective effects of saffron (Crocus sativus) extracts against DOX-induced acute cardiotoxicity in isolated rabbit hearts submitted to 30 min global ischemia followed by 40 min reperfusion.
T4 619-727 DRI_Background denotes DOX was delivered during reperfusion, without or with saffron given 5 min before ischemia or at reperfusion.
T5 728-805 DRI_Background denotes Cardiodynamic, biochemical, and histopathological parameters were determined.
T6 806-981 DRI_Outcome denotes In addition, to determine the expression of the AKT/mTOR/4EBP1 pathway, the levels of p38 MAPK and cardiac troponin T in heart homogenates were visualized by Western blotting.
T7 982-1096 DRI_Background denotes DOX administration during 40 min of reperfusion increased ischemic tissue damage, but did not act synergistically.
T8 1097-1273 DRI_Outcome denotes Administration of saffron extracts during the first minutes of reperfusion significantly reduced oxidative myocardial damage, but was less effective when given before ischemia.
T9 1274-1502 DRI_Outcome denotes Subsequent Western blot analysis revealed that saffron administration preserved cardiac troponin T proteins, inhibited the p38 MAPK pathway, and activated the AKT/mTOR/4EBP1 pathway in reperfusion- and DOX-treated rabbit hearts.
T10 1503-1683 DRI_Background denotes In conclusion, saffron extracts, acting through antioxidant and antiapoptotic mechanisms, exhibited a protective effect against DOX-induced cardiotoxicity under ischemic condition.