PubMed_ArguminSci  

PubMed:25694232 JSONTXT 8 Projects

Annnotations TAB TSV DIC JSON TextAE

Id Subject Object Predicate Lexical cue
T1 89-188 DRI_Background denotes Suncus murinus (house musk shrew; suncus) is a species of insectivore that has an ability to vomit.
T2 189-347 DRI_Background denotes Although longitudinal movement of the esophagus would be related to the emetic response, regulatory mechanisms for the suncus esophageal motility are unclear.
T3 348-462 DRI_Background denotes Therefore, the aim of the present study was to clarify components that regulate esophageal motility in the suncus.
T4 463-613 DRI_Background denotes An isolated segment of the suncus esophagus was placed in an organ bath, and longitudinal mechanical responses were recorded using a force transducer.
T5 614-695 DRI_Background denotes Electrical stimulation of the vagus trunk evoked a biphasic contractile response.
T6 696-963 DRI_Outcome denotes The first phase of the contractile response was blocked by α-bungarotoxin, a blocker of nicotinic acetylcholine receptors on striated muscle cells, whereas the second one was blocked by atropine, a blocker of muscarinic acetylcholine receptors on smooth muscle cells.
T7 964-1061 DRI_Approach denotes Next, we investigated whether mast cells are involved in motor functions of the suncus esophagus.
T8 1062-1185 DRI_Background denotes Application of a mast cell stimulator, compound 48/80, elicited contractile responses, which was resistant to tetrodotoxin.
T9 1186-1265 DRI_Background denotes Exogenous application of serotonin and histamine induced contractile responses.
T10 1266-1443 DRI_Background denotes The mast cell activation-mediated contraction was abolished by double desensitization by serotonin and histamine and pre-treatment with indomethacin, a cyclooxygenase inhibitor.
T11 1444-1631 DRI_Outcome denotes The findings show that cholinergic and non-cholinergic transmitters induce longitudinal contraction in the suncus esophagus, which might contribute to esophageal shortening during emesis.
T12 1632-1819 DRI_Background denotes Cholinergic transmitters are derived from vagal efferents, and non-cholinergic transmitters, which are thought to be serotonin, histamine and prostaglandins, are released from mast cells.