PubMed_ArguminSci  

PubMed:25315623 JSONTXT 9 Projects

Annnotations TAB TSV DIC JSON TextAE

Id Subject Object Predicate Lexical cue
T1 44-59 REPLACED denotes High-conductive
T2 78-257 DRI_Background denotes potassium channels (BK+Ca) and ATP-sensitive potassium (K+ATP) channels play a significant role in the airway smooth muscle cell and goblet cell function, and cytokine production.
T3 258-427 DRI_Background denotes The present study evaluated the therapeutic potential of BK+Ca and K+ATP openers, NS 1619 and pinacidil, respectively, in an experimental model of allergic inflammation.
T4 428-586 DRI_Background denotes Airway allergic inflammation was induced with ovalbumine in guinea pigs during 21 days, which was followed by a 14-day treatment with BK+Ca and K+ATP openers.
T5 587-823 DRI_Background denotes The outcome measures were airway smooth muscle cells reactivity in vivo and in vitro, cilia beating frequency and the level of exhaled NO (ENO), and the level of pro-inflammatory cytokines in the plasma and bronchoalveolar lavage fluid.
T6 824-960 DRI_Outcome denotes The openers of both channels decreased airway smooth muscle cells reactivity, cilia beating frequency, and cytokine levels in the serum.
T7 961-1029 DRI_Background denotes Furthermore, NS1619 reduced ENO and inflammatory cells infiltration.
T8 1030-1144 DRI_Challenge denotes The findings confirmed the presence of beneficial effects of BK+Ca and K+ATP openers on airway defence mechanisms.
T9 1145-1296 DRI_Outcome denotes Although both openers dampened pro-inflammatory cytokines and mast cells infiltration, an evident anti-inflammatory effect was provided only by NS1619.
T10 1297-1438 DRI_Challenge denotes Therefore, we conclude that particularly BK+Ca channels represent a promising new drug target in treatment of airway's allergic inflammation.