PubMed_ArguminSci  

PubMed:23208501 JSONTXT 9 Projects

Annnotations TAB TSV DIC JSON TextAE

Id Subject Object Predicate Lexical cue
T1 123-258 DRI_Background denotes Upregulation of lipogenesis is a hallmark of cancer and blocking the lipogenic pathway is known to cause tumor cell death by apoptosis.
T2 259-346 DRI_Background denotes However, the exact role of lipogenesis in tumor initiation is as yet poorly understood.
T3 347-543 DRI_Outcome denotes We examined the expression profile of key lipogenic genes in clinical samples of ductal carcinoma in situ (DCIS) of breast cancer and found that these genes were significantly upregulated in DCIS.
T4 544-811 DRI_Approach denotes We also isolated cancer stem-like cells (CSCs) from DCIS.com cell line using cell surface markers (CS24(-)CD44(+)ESA(+)) and found that this cell population has significantly higher tumor-initiating ability to generate DCIS compared with the non-stem-like population.
T5 812-990 DRI_Outcome denotes Furthermore, the CSCs showed significantly higher level of expression of all lipogenic genes than the counterpart population from non-tumorigenic breast cancer cell line, MCF10A.
T6 991-1197 DRI_Outcome denotes Importantly, ectopic expression of SREBP1, the master regulator of lipogenic genes, in MCF10A significantly enhanced lipogenesis in stem-like cells and promoted cell growth as well as mammosphere formation.
T7 1198-1384 DRI_Outcome denotes Moreover, SREBP1 expression significantly increased the ability of cell survival of CSCs from MCF10AT, another cell line that is capable of generating DCIS, in mouse and in cell culture.
T8 1385-1520 DRI_Background denotes These results indicate that upregulation of lipogenesis is a pre-requisite for DCIS formation by endowing the ability of cell survival.
T9 1521-1784 DRI_Outcome denotes We have also shown that resveratrol was capable of blocking the lipogenic gene expression in CSCs and significantly suppressed their ability to generate DCIS in animals, which provides us with a strong rationale to use this agent for chemoprevention against DCIS.