| Id |
Subject |
Object |
Predicate |
Lexical cue |
| T1 |
59-208 |
DRI_Background |
denotes |
Inherited mutations in the mismatch repair (MMR) genes MSH2 and MLH1 are found in most hereditary nonpolyposis colon cancer (HNPCC) patients studied. |
| T2 |
209-426 |
DRI_Background |
denotes |
Eukaryotic MMR uses two partially redundant mispair-recognition complexes, Msh2p-Msh6p and Msh2p-Msh3p (ref.2) Inactivation of MSH2 causes high rates of accumulation of both base-substitution and frameshift mutations. |
| T3 |
427-669 |
DRI_Background |
denotes |
Mutations in MSH6 or MSH3 cause partial defects in MMR, with inactivation of MSH6 resulting in high rates of base-substitution mutations and low rates of frameshift mutations; inactivation of MSH3 results in low rates of frameshift mutations. |
| T4 |
670-842 |
DRI_Background |
denotes |
These different mutator phenotypes provide an explanation for the observation that MSH2 mutations are common in HNPCC families, whereas mutations in MSH3 and MSH6 are rare. |
| T5 |
843-994 |
DRI_Approach |
denotes |
We have identified novel missense mutations in Saccharomyces cerevisiae MSH6 that appear to inactivate both Msh2p-Msh6p- and Msh2p-Msh3p-dependent MMR. |
| T6 |
995-1134 |
DRI_Outcome |
denotes |
Our work suggests that such mutations may underlie some cases of inherited cancer susceptibility similar to those caused by MSH2 mutations. |
