PubMed:23763943 JSONTXT 8 Projects

Efavirenz induced acute liver failure requiring liver transplantation in a slow drug metaboliser. Highly active antiretroviral therapy has revolutionised HIV management. However, many of these drugs are potentially hepatotoxic. Here, we report the first adult case of efavirenz induced acute liver failure successfully treated by liver transplantation. Furthermore, genetic analysis revealed our patient to be a slow efavirenz metaboliser, contributing to the severity of clinical presentation.