| Id |
Subject |
Object |
Predicate |
Lexical cue |
| T1 |
0-99 |
Sentence |
denotes |
Can SARS-CoV-2 infect the central nervous system via the olfactory bulb or the blood-brain barrier? |
| T2 |
100-202 |
Sentence |
denotes |
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) emerged in Wuhan, China in December 2019. |
| T3 |
203-325 |
Sentence |
denotes |
On February 11, the World Health Organization (WHO) announced the name for the new illness caused by SARS-CoV-2: COVID-19. |
| T4 |
326-399 |
Sentence |
denotes |
By March 11, the outbreak of COVID-19 was declared a pandemic by the WHO. |
| T5 |
400-519 |
Sentence |
denotes |
This virus has extensively altered daily life for many across the globe, while claiming hundreds of thousands of lives. |
| T6 |
520-655 |
Sentence |
denotes |
While fundamentally a respiratory illness, many infected individuals experience symptoms that involve the central nervous system (CNS). |
| T7 |
656-753 |
Sentence |
denotes |
It is likely that many of these symptoms are the result of the virus residing outside of the CNS. |
| T8 |
754-975 |
Sentence |
denotes |
However, the current evidence does indicate that the SARS-CoV-2 virus can use olfactory neurons to travel from the periphery into the CNS, and that the virus may also enter the brain through the blood-brain barrier (BBB). |
| T9 |
976-1180 |
Sentence |
denotes |
We discuss how the virus may use established infection mechanisms (ACE2, TMPRSS2, and Cathepsin L), as well mechanisms still under consideration (NRP1 and BASIGIN) to infect and spread throughout the CNS. |
| T10 |
1181-1302 |
Sentence |
denotes |
Confirming the impact of the virus on the CNS will be crucial in dealing with the long-term consequences of the epidemic. |
