LitCovid-sentences  

PubMed:33113325 JSONTXT 20 Projects

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Id Subject Object Predicate Lexical cue
T1 0-167 Sentence denotes Early Initiation of Extracorporeal Blood Purification Using the AN69ST (oXiris®) Hemofilter as a Treatment Modality for COVID-19 Patients: a Single-Centre Case Series.
T2 168-181 Sentence denotes INTRODUCTION:
T3 182-377 Sentence denotes Severe coronavirus disease 2019 (COVID-19) is characterised by hyperinflammatory state, systemic coagulopathies, and multiorgan involvement, especially acute respiratory distress syndrome (ARDS).
T4 378-585 Sentence denotes We here describe our preliminary clinical experience with COVID-19 patients treated via an early initiation of extracorporeal blood purification combined with systemic heparinisation and respiratory support.
T5 586-594 Sentence denotes METHODS:
T6 595-695 Sentence denotes Fifteen patients were included; several biomarkers associated with COVID-19 severity were monitored.
T7 696-919 Sentence denotes Personalised treatment was tailored according to the levels of interleukin (IL)-6, IL- 8, tumour necrosis factor alpha, C-reactive protein (CRP), neutrophilto- lymphocyte ratio, thrombocyte counts, D-dimers, and fibrinogen.
T8 920-1109 Sentence denotes Treatment consisted of respiratory support, extracorporeal blood purification using the AN69ST (oXiris®) hemofilter, and 300 U/kg heparin to maintain activation clotting time ≥ 180 seconds.
T9 1110-1118 Sentence denotes RESULTS:
T10 1119-1301 Sentence denotes Ten patients presented with severe to critical disease (dyspnoea, hypoxia, respiratory rate > 30/min, peripheral oxygen saturation < 90%, or > 50% lung involvement on X-ray imaging).
T11 1302-1450 Sentence denotes The median intensive care unit length of stay was 9.3 days (interquartile range 5.3-10.1); two patients developed ARDS and died after 5 and 26 days.
T12 1451-1629 Sentence denotes Clinical improvement was associated with normalisation (increase) of thrombocytes and white blood cells, stable levels of IL-6 (< 50 ng/mL), and a decrease of CRP and fibrinogen.
T13 1630-1641 Sentence denotes CONCLUSION:
T14 1642-1835 Sentence denotes Continuous monitoring of COVID-19 severity biomarkers and radiological imaging is crucial to assess disease progression, uncontrolled inflammation, and to avert irreversible multiorgan failure.
T15 1836-2054 Sentence denotes The combination of systemic heparin anticoagulation regimens and extracorporeal blood purification using cytokine-adsorbing hemofilters may reduce hyperinflammation, prevent coagulopathy, and support clinical recovery.