LitCovid-sentences  

PubMed:32214286 JSONTXT 34 Projects

Annnotations TAB TSV DIC JSON TextAE

Id Subject Object Predicate Lexical cue
T1 0-128 Sentence denotes Expanded Umbilical Cord Mesenchymal Stem Cells (UC-MSCs) as a Therapeutic Strategy in Managing Critically Ill COVID-19 Patients:
T2 129-160 Sentence denotes The Case for Compassionate Use.
T3 161-364 Sentence denotes COVID-19 has affected the United States leading to a national emergency with health care and economic impact, propelling the country into a recession with disrupted lifestyles not seen in recent history.
T4 365-471 Sentence denotes COVID-19 is a serious illness leading to multiple deaths in various countries including the United States.
T5 472-587 Sentence denotes Several million Americans satisfy the Center for Disease Control and Prevention (CDC) criteria for being high risk.
T6 588-726 Sentence denotes Unfortunately, the available supply of medical beds and equipment for mechanical ventilation are much less than is projected to be needed.
T7 727-959 Sentence denotes The World Health Organization (WHO) and multiple agencies led by the CDC in the United States have attempted to organize intensive outbreak investigation programs utilizing appropriate preventive measures, evaluation, and treatment.
T8 960-1164 Sentence denotes The clinical spectrum of COVID-19 varies from asymptomatic forms to conditions encompassing multiorgan and systemic manifestations in terms of septic shock, and multiple organ dysfunction (MOD) syndromes.
T9 1165-1247 Sentence denotes The presently approved treatments are supportive but not curative for the disease.
T10 1248-1292 Sentence denotes There are multiple treatments being studied.
T11 1293-1399 Sentence denotes These include vaccines, medications Remdesivir and hydroxychloroquine and potentially combination therapy.
T12 1400-1507 Sentence denotes Finally, expanded umbilical cord mesenchymal stem cells or (UC-MSCs) may have a role and are being studied.
T13 1508-1589 Sentence denotes The cure of COVID-19 is essentially dependent on the patients' own immune system.
T14 1590-1774 Sentence denotes When the immune system is over activated in an attempt to kill the virus, this can lead to the production of a large number of inflammatory factors, resulting in severe cytokine storm.
T15 1775-1985 Sentence denotes The cytokine storm may induce organ damage followed by the edema, dysfunction of air exchange, acute respiratory distress syndrome (ARDS), acute cardiac injury, and secondary infection, which may lead to death.
T16 1986-2247 Sentence denotes Thus, at this point, the avoidance of the cytokine storm may be the key for the treatment of HCOV-19 infected patients.In China, where there was limited availability of effective modalities to manage COVID-19 several patients were treated with expanded UC-MSCs.
T17 2248-2532 Sentence denotes Additionally, the Italian College of Anesthesia, Analgesia, Resuscitation and Intensive Care have reported guidelines to treat coronavirus patients with stem cells in the hope of decreasing the number of patients going to the ICU, and, also relatively quickly getting them out of ICU.
T18 2533-2700 Sentence denotes In this manuscript, we describe the urgent need for various solutions, pathogenesis of coronavirus and the clinical evidence for treatment of COVID-19 with stem cells.
T19 2701-2914 Sentence denotes The limited but emerging evidence regarding UC MSC in managing COVID-19 suggests that it might be considered for compassionate use in critically ill patients to reduce morbidity and mortality in the United States.
T20 2915-3113 Sentence denotes The administration and Coronavirus Task Force might wish to approach the potential of expanded UC-MSCs as an evolutionary therapeutic strategy in managing COVID-19 illness with a 3-pronged approach:
T21 3114-3177 Sentence denotes If proven safe and effective on a specific and limited basis…1.
T22 3178-3324 Sentence denotes Minimize regulatory burden by all agencies so that critically ill COVID-19 patients will have access regardless of their financial circumstance.2.
T23 3325-3416 Sentence denotes Institute appropriate safeguards to avoid negative consequences from unscrupulous actors.3.
T24 3417-3659 Sentence denotes With proper informed consent from patients or proxy when necessary, and subject to accumulation of data in that cohort, allow the procedure to be initiated in critically ill patients who are not responding to conventional therapies.KEY WORDS:
T25 3660-3766 Sentence denotes Coronavirus, COVID-19, cytokine storm, multiorgan failure, expanded umbilical cord mesenchymal stem cells.