PubMed:32164089 JSONTXT 20 Projects

Annnotations TAB TSV DIC JSON TextAE

Id Subject Object Predicate Lexical cue
T1 0-85 Sentence denotes [Analysis of clinical features of 29 patients with 2019 novel coronavirus pneumonia].
T2 86-96 Sentence denotes Objective:
T3 97-285 Sentence denotes To analyze the clinical characteristics of 2019 novel coronavirus (2019-nCoV) pneumonia and to investigate the correlation between serum inflammatory cytokines and severity of the disease.
T4 286-294 Sentence denotes Methods:
T5 295-510 Sentence denotes 29 patients with 2019-ncov admitted to the isolation ward of Tongji hospital affiliated to Tongji medical college of Huazhong University of Science and Technology in January 2020 were selected as the study subjects.
T6 511-644 Sentence denotes Clinical data were collected and the general information, clinical symptoms, blood test and CT imaging characteristics were analyzed.
T7 645-794 Sentence denotes According to the relevant diagnostic criteria, the patients were divided into three groups: mild (15 cases), severe (9 cases) and critical (5 cases).
T8 795-1065 Sentence denotes The expression levels of inflammatory cytokines and other markers in the serum of each group were detected, and the changes of these indicators of the three groups were compared and analyzed, as well as their relationship with the clinical classification of the disease.
T9 1066-1194 Sentence denotes Results: (1) The main symptoms of 2019-nCoV pneumonia was fever (28/29) with or without respiratory and other systemic symptoms.
T10 1195-1496 Sentence denotes Two patients died with underlying disease and co-bacterial infection, respectively. (2) The blood test of the patients showed normal or decreased white blood cell count (23/29), decreased lymphocyte count (20/29), increased hypersensitive C reactive protein (hs-CRP) (27/29), and normal procalcitonin.
T11 1497-1622 Sentence denotes In most patients, serum lactate dehydrogenase (LDH) was significantly increased (20/29), while albumin was decreased (15/29).
T12 1623-1901 Sentence denotes Alanine aminotransferase (ALT), aspartate aminotransferase (AST), total bilirubin (Tbil), serum creatinine (Scr) and other items showed no significant changes. (3) CT findings of typical cases were single or multiple patchy ground glass shadows accompanied by septal thickening.
T13 1902-2336 Sentence denotes When the disease progresses, the lesion increases and the scope expands, and the ground glass shadow coexists with the solid shadow or the stripe shadow. (4) There were statistically significant differences in the expression levels of interleukin-2 receptor (IL-2R) and IL-6 in the serum of the three groups (P<0.05), among which the critical group was higher than the severe group and the severe group was higher than the mild group.
T14 2337-2538 Sentence denotes However, there were no statistically significant differences in serum levels of tumor necrosis factor-alpha (TNF-α), IL-1, IL-8, IL-10, hs-CRP, lymphocyte count and LDH among the three groups (P>0.05).
T15 2539-2550 Sentence denotes Conclusion:
T16 2551-2650 Sentence denotes The clinical characteristics of 2019-nCoV pneumonia are similar to those of common viral pneumonia.
T17 2651-2734 Sentence denotes High resolution CT is of great value in the differential diagnosis of this disease.
T18 2735-2880 Sentence denotes The increased expression of IL-2R and IL-6 in serum is expected to predict the severity of the 2019-nCoV pneumonia and the prognosis of patients.