LitCovid-sentences  

PMC:7799377 / 6838-8615 JSONTXT 3 Projects

Annnotations TAB TSV DIC JSON TextAE

Id Subject Object Predicate Lexical cue
T51 0-261 Sentence denotes The viruses associated with both SARS and COVID-19 enter the brain via a process involving the angiotensin-converting enzyme (ACE)-2 receptors located in the CNS [17–19], unlike the MERS virus, which gains entry via the plasma membrane or in the endosomes [20].
T52 262-377 Sentence denotes ACE-2 receptors are expressed in many parts of the body and are particularly densely expressed in the nasal mucosa.
T53 378-582 Sentence denotes Coronaviruses that enter the body via the nasal mucosa may disrupt the nasal endothelium, cross the epithelial barrier, and then directly enter the lymphatic or circulatory system, accessing the CNS [21].
T54 583-691 Sentence denotes The SARS-CoV has been detected in the brain, and it is thought entry occurred by way of the olfactory nerve.
T55 692-878 Sentence denotes Since there have been studies that located the SARS-CoV virus in the CNS but not the lung, it suggests that there is a direct pathway from the olfactory point of entry into the CNS [22].
T56 879-1144 Sentence denotes Alternatively, a high viral load in the brain following a pulmonary infection might mean the virus entered the brain from the respiratory system; e.g., the vagus nerve links the respiratory system to the nucleus ambiguous and solitary tract nuclei of the brainstem.
T57 1145-1308 Sentence denotes It has been speculated that the cardiorespiratory center of the brain may be involved in the severe acute respiratory distress in some patients with COVID-19 [23].
T58 1309-1547 Sentence denotes The more common form of respiratory failure in COVID-19 patients is Type 1 (gas exchange dysfunction resulting in hypoxia and low levels of carbon dioxide), which is more likely to be associated with pneumonia than brain dysfunction [24].
T59 1548-1777 Sentence denotes Type 2 respiratory failure, which involves both hypoxia and high levels of carbon dioxide due to ventilatory failure would be more suggestive of neurological dysfunction, and this occurs less frequently in COVID-19 patients [25].