Id |
Subject |
Object |
Predicate |
Lexical cue |
T191 |
0-29 |
Sentence |
denotes |
Guillain-Barré syndrome (GBS) |
T192 |
30-110 |
Sentence |
denotes |
GBS typically involves demyelination and presents in both upper and lower limbs. |
T193 |
111-289 |
Sentence |
denotes |
While there is no clear evidence to date associating the SARS-CoV-2 virus with GBS, other viral infections, such as influenza and the Epstein-Barr virus, have been linked to GBS. |
T194 |
290-459 |
Sentence |
denotes |
The association is based on the idea that there can be molecular mimicry between certain viral proteins and the gangliosides and other proteins on the peripheral nerves. |
T195 |
460-573 |
Sentence |
denotes |
This can result in an ‘innocent bystander attack’ against the myelin sheath or axon of the peripheral nerve [70]. |
T196 |
574-769 |
Sentence |
denotes |
GBS is a complex disorder and has been recognized as a para-infectious neurological disease, and has associations with the Zika virus that were documented during the 2015–2016 Zika epidemic [90]. |
T197 |
770-839 |
Sentence |
denotes |
It is not known if the coronavirus can damage peripheral nerves [44]. |
T198 |
840-1192 |
Sentence |
denotes |
The literature reports on several cases that suggest a link between COVID-19 and GBS [91–94], for example, the case of a 62-year-old COVID patient with GBS; however it is unclear if this patient, who had comorbid lymphopenia and thrombocytopenia, developed GBS and COVID-19 independently but concurrently, or if COVID-19 might have caused the GBS [95]. |
T199 |
1193-1316 |
Sentence |
denotes |
It must likewise be considered that COVID-19-associated neurological manifestations may emerge after the initial infection. |
T200 |
1317-1435 |
Sentence |
denotes |
Thus, while there is currently no evidence that COVID-19 can cause GBS, it is an area worthy of further investigation. |
T201 |
1436-1665 |
Sentence |
denotes |
It should be noted in this context that clinicians may sometimes observe peripheral neuropathies, for example based around the ulna, that have to do with prolonged intubation periods in a position that impinges the cubital canal. |