PMC:7799377 / 29258-30923 JSONTXT 3 Projects

Annnotations TAB TSV DIC JSON TextAE

Id Subject Object Predicate Lexical cue
T191 0-29 Sentence denotes Guillain-Barré syndrome (GBS)
T192 30-110 Sentence denotes GBS typically involves demyelination and presents in both upper and lower limbs.
T193 111-289 Sentence denotes While there is no clear evidence to date associating the SARS-CoV-2 virus with GBS, other viral infections, such as influenza and the Epstein-Barr virus, have been linked to GBS.
T194 290-459 Sentence denotes The association is based on the idea that there can be molecular mimicry between certain viral proteins and the gangliosides and other proteins on the peripheral nerves.
T195 460-573 Sentence denotes This can result in an ‘innocent bystander attack’ against the myelin sheath or axon of the peripheral nerve [70].
T196 574-769 Sentence denotes GBS is a complex disorder and has been recognized as a para-infectious neurological disease, and has associations with the Zika virus that were documented during the 2015–2016 Zika epidemic [90].
T197 770-839 Sentence denotes It is not known if the coronavirus can damage peripheral nerves [44].
T198 840-1192 Sentence denotes The literature reports on several cases that suggest a link between COVID-19 and GBS [91–94], for example, the case of a 62-year-old COVID patient with GBS; however it is unclear if this patient, who had comorbid lymphopenia and thrombocytopenia, developed GBS and COVID-19 independently but concurrently, or if COVID-19 might have caused the GBS [95].
T199 1193-1316 Sentence denotes It must likewise be considered that COVID-19-associated neurological manifestations may emerge after the initial infection.
T200 1317-1435 Sentence denotes Thus, while there is currently no evidence that COVID-19 can cause GBS, it is an area worthy of further investigation.
T201 1436-1665 Sentence denotes It should be noted in this context that clinicians may sometimes observe peripheral neuropathies, for example based around the ulna, that have to do with prolonged intubation periods in a position that impinges the cubital canal.