LitCovid-sentences  

PMC:7799377 / 25739-29256 JSONTXT 3 Projects

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Id Subject Object Predicate Lexical cue
T169 0-14 Sentence denotes Encephalopathy
T170 15-209 Sentence denotes Encephalopathy, which often presents in infectious disease patients as delirium, is a brain disorder that causes acute or subacute dysfunction in terms of consciousness or altered mental states.
T171 210-363 Sentence denotes The elderly, people with cognitive deficits, and people with hypertension are elevated risk for developing an altered mental state with COVID-19 [52,74].
T172 364-516 Sentence denotes Cerebral edema, a dangerous condition which can cause elevated intracranial pressure and encephalopathy, has been identified in COVID-19 decedents [75].
T173 517-680 Sentence denotes Those with a history of neurological damage and acute respiratory distress are at elevated risk for developing encephalopathy as the initial COVID-19 symptom [76].
T174 681-829 Sentence denotes The risk becomes greater as the COVID-19 becomes more severe; altered consciousness occurs in 2.4% of mild and 15% of severe COVID-19 patients [52].
T175 830-940 Sentence denotes The risk for delirium, like the risk for worse outcomes with COVID-19, is also associated with older age [77].
T176 941-1065 Sentence denotes The use of sedatives, which is common in critically ill patients, may also be associated with the risk for delirium [78,79].
T177 1066-1329 Sentence denotes Social distancing mandated for COVID-19 may actually contribute to the rate of delirium of certain COVID-19 patients, who may feel desperate and panicked as they are isolated, separated from family, alone, and/or denied religious support from a clergyperson [77].
T178 1330-1650 Sentence denotes Delirium in hospitalized COVID-19 patients may be the result of direct CNS invasion, induction of CNS inflammatory mediators, a secondary effect of other organ system failures, the effect of sedation, the result of prolonged mechanical ventilation, a psychological manifestation, or caused by environmental factors [77].
T179 1651-1917 Sentence denotes In cases of COVID-19, it is thought that delirium caused by direct invasion of the virus into the CNS is relatively rare, but possible, and would likely be accompanied by seizures, altered states of consciousness, or signs of increased intracranial pressure [39,46].
T180 1918-2018 Sentence denotes The rates and presentation of encephalopathy and delirium in COVID-19 patients has not been studied.
T181 2019-2208 Sentence denotes Delirium in COVID-19 patients may be under-reported to date, indeed delirium is thought to be widely under-reported for various conditions unless it is being specifically monitored [79–82].
T182 2209-2287 Sentence denotes Case studies of COVID-19-associated delirium appear in the literature [83,84].
T183 2288-2412 Sentence denotes Acute necrotizing encephalopathy, although relatively rare, has also been diagnosed in a hospitalized COVID-19 patient [85].
T184 2413-2592 Sentence denotes Overall, ICU patients on mechanical ventilation have rates of delirium as high as 70% to 75%, and delirium is associated with mortality and long-term cognitive impairment [86–88].
T185 2593-2726 Sentence denotes The causes of COVID-19-associated encephalopathy may involve multiple factors, including metabolic causes, hypoxia, and drug therapy.
T186 2727-2820 Sentence denotes Symptomatic treatment involves antipyretics, anticonvulsants, and treatment for hypoxia [21].
T187 2821-2980 Sentence denotes Early signs of delirium in COVID-19 patients might suggest CNS involvement and, as such, might indicate heightened risk for impending respiratory failure [77].
T188 2981-3226 Sentence denotes In a study of 27 pediatric COVID-19 patients with multisystem inflammatory syndrome, 15% (n = 4) exhibited new-onset neurological symptoms, such as encephalopathy, headaches, brainstem, and cerebellar signs, weak muscles, and poor reflexes [89].
T189 3227-3417 Sentence denotes Cerebrospinal fluid testing in two patients were acellular; three patients underwent nerve conduction and electromyographical studies, which revealed mild myopathic and neuropathic deficits.
T190 3418-3517 Sentence denotes All four patients improved, two of whom made a complete recovery over the course of the study [89].