LitCovid-sentences  

PMC:7784834 / 3052-6070 JSONTXT 2 Projects

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Id Subject Object Predicate Lexical cue
T28 0-429 Sentence denotes Similar to SARS-CoV and MERS-CoV, SARS-CoV-2 (exhibiting 80% and 50% homology, respectively) (Kim et al., 2020; Zhu et al., 2020) belongs to the genera beta coronavirus (family Coronaviridae in the order Nidovirales) (Enjuanes et al., 2006; Perlman & Netland, 2009), which is known to infect mammals (Li, 2016) and has manifested an illustrious capability of cross-species transmission, including humans (Menachery et al., 2017).
T29 430-616 Sentence denotes The SARS-CoV-2 is an enveloped virus characterized by a positive-sense, single-stranded RNA genome of almost 30 kb, surrounded by a helical capsid comprised of nucleo capsid protein (N).
T30 617-884 Sentence denotes The viral envelope is associated with three primary structural proteins viz. membrane proteins (M) and envelope proteins (E), which perform virus assembly; and spike proteins (S), which facilitate the viral attachment and thus, the virus entrance into the host cells.
T31 885-1042 Sentence denotes The large protrusions formed by spikes on the surface of the virus give it the appearance of having crowns, which, in Latin, translates to corona (Li, 2016).
T32 1043-1168 Sentence denotes These shorter, sgRNA-encoded structural proteins and several accessory proteins are known to be conserved (Kim et al., 2020).
T33 1169-1267 Sentence denotes The large ectodomain of the spike consists of receptor binding S1 and membrane fusion S2 subunits.
T34 1268-1334 Sentence denotes For many CoVs, the S1 and S2 domains remain non-covalently linked.
T35 1335-1416 Sentence denotes In β coronaviruses, the cleavage between the S1 and S2 regions is not obligatory.
T36 1417-1628 Sentence denotes However, the host proteases have been observed to cause cleavage within the fusion domain (S2), which leads to irreversible conformational changes, activating the protein for membrane fusion (Zhou et al., 2020).
T37 1629-1766 Sentence denotes The S2 subunit contains two regions with 4, 3 hydrophobic heptad repeats (HR), HR1 and HR2, which are conserved in sequence and position.
T38 1767-1876 Sentence denotes The HR2 is located adjacent to the trans-membrane domain, while the HR1 occurs ∼170 residues upstream of HR2.
T39 1877-1963 Sentence denotes The HR region has been observed to be a common motif in several viral fusion proteins.
T40 1964-2255 Sentence denotes Structurally, the HR1 domain exists as a homo-trimeric coil, packing the HR2 domain (in an anti-parallel manner) in its hydrophobic grooves, thereby bringing the N-terminal fusion peptide closer to the trans-membrane anchor, further facilitating fusion due to proximity (Bosch et al., 2003).
T41 2256-2544 Sentence denotes Various host receptors viz. angiotensin-converting enzyme 2 (ACE2), amino peptidase N (APN), dipeptidyl peptidase 4 (DPP4), carcinoembryonic antigen-related cell adhesion molecule 1 (CEACAM1), and sugar recognize S1 domain of the spike protein to render virus entry into cells (Li, 2016).
T42 2545-3018 Sentence denotes Several reports have been published recently discovering inhibitors against the target via a computational methodologies, which involve the usage of FDA approved compounds and natural compounds (Wei et al., 2020), spice molecules (Rout et al., 2020), small-molecule compounds of ZINC Drug Database (Kadioglu, 2020; Wu et al., 2020) along with traditional Chinese medicine and natural products and derivatives (Wu et al., 2020) and medicinal compounds (Salman et al., 2020).