LitCovid-sentences  

PMC:7784829 / 194-1737 JSONTXT 2 Projects

Annnotations TAB TSV DIC JSON TextAE

Id Subject Object Predicate Lexical cue
T7 0-92 Sentence denotes COVID-19, a new pandemic caused by SARS-CoV-2, was first identified in 2019 in Wuhan, China.
T8 93-222 Sentence denotes The novel corona virus SARS-CoV-2 and the 2002 SARS-CoV have 74% identity and use similar mechanisms to gain entry into the cell.
T9 223-364 Sentence denotes Both the viruses enter the host cell by binding of the viral spike glycoprotein to the host receptor, angiotensin converting enzyme 2 (ACE2).
T10 365-474 Sentence denotes Targeting entry of the virus has a better advantage than inhibiting the later stages of the viral life cycle.
T11 475-579 Sentence denotes The crystal structure of the SARS-CoV (6CRV: full length S protein) and SARS-CoV-2 Spike proteins (6M0J:
T12 580-668 Sentence denotes Receptor binding domain, RBD) was used to determine potential small molecule inhibitors.
T13 669-783 Sentence denotes Curcumin, a naturally occurring phytochemical in Curcuma longa, is known to have broad pharmacological properties.
T14 784-984 Sentence denotes In the present study, curcumin and its derivatives were docked, using Autodock 4.2, onto the 6CRV and 6M0J to study their capability to act as inhibitors of the spike protein and thereby, viral entry.
T15 985-1131 Sentence denotes The curcumin and its derivatives displayed binding energies, ΔG, ranging from −10.98 to −5.12 kcal/mol (6CRV) and −10.01 to −5.33 kcal/mol (6M0J).
T16 1132-1252 Sentence denotes The least binding energy was seen in bis-demethoxycurcumin with: ΔG = −10.98 kcal/mol (6CRV) and −10.01 kcal/mol (6M0J).
T17 1253-1431 Sentence denotes A good binding energy, drug likeness and efficient pharmacokinetic parameters suggest the potential of curcumin and few of its derivatives as SARS-CoV-2 spike protein inhibitors.
T18 1432-1543 Sentence denotes However, further research is necessary to investigate the ability of these compounds as viral entry inhibitors.