LitCovid-sentences  

PMC:7784828 / 3987-8487 JSONTXT 3 Projects

Annnotations TAB TSV DIC JSON TextAE

Id Subject Object Predicate Lexical cue
T40 0-4 Sentence denotes 2.1.
T41 6-38 Sentence denotes Alarming pace of deadly diseases
T42 39-147 Sentence denotes Death rates due to diseases largely depend on access to health care and availability of effective medicines.
T43 148-294 Sentence denotes The vast majority of the deadliest diseases are partially preventable with better access to preventive procedures and quality healthcare delivery.
T44 295-484 Sentence denotes With the advancements in medical sciences, we have seen a drastic reduction in death rates for many devastating diseases in developed nations and to a lesser extent in developing countries.
T45 485-585 Sentence denotes A brief summary of the global medical challenges the humankind continues to face is presented below.
T46 587-593 Sentence denotes 2.1.1.
T47 595-614 Sentence denotes Infectious diseases
T48 615-671 Sentence denotes Malaria is an ancient scourge as old as humanity itself.
T49 672-771 Sentence denotes There are over 200 million new infections and around half a million deaths reported every year [5].
T50 772-910 Sentence denotes Despite many attempts to design effective vaccines, none has been successful at providing long-lasting benefits at a population level [9].
T51 911-1092 Sentence denotes Tuberculosis (TB) remains one of the top 10 causes of death worldwide, with 10,000 million infections and 1.5 million deaths in 2018 according to the world health organization [10].
T52 1093-1174 Sentence denotes Likewise, viruses continue to compromise the lives of tens of millions of people.
T53 1175-1320 Sentence denotes Globally, influenza virus infects a 1 billion people and causes up to 650,000 deaths every year despite the availability of the flu vaccine [11].
T54 1321-1425 Sentence denotes Viral infections inflect heavy societal and economic burdens beside their morbidity and mortality tolls.
T55 1426-1689 Sentence denotes The past half century has witnessed deadly outbreaks of novel viruses of animal origin other than SARS-CoV2 such as Nipah, Hendra, Hanta, Ebola, several influenza subtypes, SARS (Severe Acute Respiratory Syndrome) and MERS (Middle East Respiratory Syndrome) [12].
T56 1690-1896 Sentence denotes These outbreaks warn the urgency of understanding the factors influencing viral diseases emergence and spread as well as global preparedness to halt these epidemics from becoming a full-blown pandemic [13].
T57 1897-1975 Sentence denotes Multidrug resistance is yet another emergent global public health threat [14].
T58 1976-2183 Sentence denotes The emergence and spread of antimicrobial resistance (AMR) among bacterial pathogen are responsible for more than 700,000 deaths per year, and is projected to cause a 10 million deaths per year by 2050 [15].
T59 2184-2380 Sentence denotes The World Health Organization along with several other organization have called an urgent action to tackle the spread of antimicrobial resistance and invest in development of new antibiotics [16].
T60 2382-2388 Sentence denotes 2.1.2.
T61 2390-2396 Sentence denotes Cancer
T62 2397-2463 Sentence denotes Cancer remains as the second leading cause of mortality worldwide.
T63 2464-2562 Sentence denotes In 2018, cancer have affected an estimated 18.1 million people and caused 9.6 million deaths [17].
T64 2563-2741 Sentence denotes A close watch at the statistics reveals that cancer kills around 10 million people every year; which is about 20,000 people every day; that correlates to one person every second.
T65 2742-2867 Sentence denotes The number of cancer deaths in the United States alone is predicted to increase to 946,833 in 2030 from 595,690 in 2016 [18].
T66 2868-3028 Sentence denotes These disturbing figures desperately calls for the need to develop early diagnostics, novel, and effective medicines as well as new drug development strategies.
T67 3029-3205 Sentence denotes Partial solutions to this challenge by precision medicine and immunotherapy has been firmly established, merits to the recent inventions in cancer genomics and immunology [18].
T68 3207-3213 Sentence denotes 2.1.3.
T69 3215-3227 Sentence denotes CNS diseases
T70 3228-3331 Sentence denotes Another significant growing healthcare need with a major economic and medical impacts is Dementia [19].
T71 3332-3547 Sentence denotes Globally, dementia affects around 50 million people, and over the past 18 years, the percentage of death among Alzheimer’s patients doubled while deaths resulting from stroke, and heart diseases have decreased [20].
T72 3548-3714 Sentence denotes In the US alone the number of Alzheimer’s dementia cases is expected to shoot up to 13.8 million and impose a health care burden of 1.1 trillion dollars by 2050 [20].
T73 3715-3814 Sentence denotes As of today, there are no medications known to reverse the progression of Alzheimer’s disease [21].
T74 3816-3822 Sentence denotes 2.1.4.
T75 3824-3837 Sentence denotes Rare diseases
T76 3838-3961 Sentence denotes Although individual occurrence is rare, collectively rare diseases is a problem affecting 6–8% of the world population [7].
T77 3962-4100 Sentence denotes The Rare Diseases Clinical Research Network was established by The National Institutes of Health (NIH) to address these unique challenges.
T78 4101-4169 Sentence denotes Among the 7,000 rare diseases, treatments are available only for 5%.
T79 4170-4332 Sentence denotes Altogether across the globe, there are 350 million people diagnosed with rare diseases and half of them are children, a third of which are below 5-years old [22].
T80 4333-4500 Sentence denotes There is a great disparity in access to orphan medicinal products (OMPs) and healthcare services among world countries despite mounting international initiatives [23].