LitCovid-sentences  

PMC:7784824 / 188-1889 JSONTXT 2 Projects

Annnotations TAB TSV DIC JSON TextAE

Id Subject Object Predicate Lexical cue
T6 0-8 Sentence denotes ABSTRACT
T7 9-20 Sentence denotes Background:
T8 21-196 Sentence denotes Molecular detection of SARS-CoV-2 in respiratory samples is the gold standard for COVID-19 diagnosis but it has a long turnaround time and struggles to detect low viral loads.
T9 197-279 Sentence denotes Serology could help to diagnose suspected cases which lack molecular confirmation.
T10 280-327 Sentence denotes Two case reports are presented as illustration.
T11 328-339 Sentence denotes Objectives:
T12 340-445 Sentence denotes The aim of this study was to evaluate the performance of several commercial assays for COVID-19 serology.
T13 446-561 Sentence denotes We illustrated the added value of COVID-19 serology testing in suspect COVID-19 cases with negative molecular test.
T14 562-575 Sentence denotes Study design:
T15 576-700 Sentence denotes Twenty-three sera from 7 patients with a confirmed molecular diagnosis of SARS-CoV-2 were tested using 14 commercial assays.
T16 701-788 Sentence denotes Additionally, 10 pre-pandemic sera and 9 potentially cross-reactive sera were selected.
T17 789-831 Sentence denotes We calculated sensitivity and specificity.
T18 832-1026 Sentence denotes Furthermore, we discuss the diagnostic relevance of COVID-19 serology in a retrospective cohort of 145 COVID-19 cases in which repetitive molecular and serological SARS-CoV-2 tests were applied.
T19 1027-1035 Sentence denotes Results:
T20 1036-1175 Sentence denotes The interpretation of the pooled sensitivity of IgM/A and IgG resulted in the highest values (range 14–71% on day 2–7; 88–94% on day 8–18).
T21 1176-1240 Sentence denotes Overall, the specificity of the assays was high (range 79–100%).
T22 1241-1380 Sentence denotes Among 145 retrospective cases, 3 cases (2%) remained negative after sequential molecular testing but positive on final SARS-CoV-2 serology.
T23 1381-1392 Sentence denotes Conclusion:
T24 1393-1510 Sentence denotes Sensitivity of COVID-19 serological diagnosis was variable but consistently increased at >7 days after symptom onset.
T25 1511-1532 Sentence denotes Specificity was high.
T26 1533-1701 Sentence denotes Our data suggest that serology can complement molecular testing for diagnosis of COVID-19, especially for patients presenting the 2nd week after symptom onset or later.