LitCovid-sentences  

PMC:7784824 / 16465-21147 JSONTXT 2 Projects

Annnotations TAB TSV DIC JSON TextAE

Id Subject Object Predicate Lexical cue
T179 0-10 Sentence denotes Discussion
T180 11-130 Sentence denotes In this study, we evaluated the detection of SARS-CoV-2 antibodies (IgM/A or IgG) with 14 different serological assays.
T181 131-283 Sentence denotes As expected, we found that sensitivity was higher if the test was performed starting from day 8 after symptom onset, as compared to earlier time points.
T182 284-458 Sentence denotes With the exception of one assay (Liaison SARS-CoV-2 S1/S2 IgG (DiaSorin), all tests resulted in a sensitivity for IgG higher than 87% starting from day 8 after symptom onset.
T183 459-492 Sentence denotes Specificity ranged from 79%-100%.
T184 493-587 Sentence denotes Recently, the first studies evaluating several commercial serology assays have been published.
T185 588-702 Sentence denotes Geurts van Kessel et al [17]. studied three rapid tests, four ELISAs and a high throughput chemiluminescent assay.
T186 703-824 Sentence denotes Sensitivity ranging from 81–100% was calculated by using a total of 187 sera from 107 RT-PCR confirmed COVID-19 patients.
T187 825-998 Sentence denotes Specificity was determined using 147 serum and plasma samples from individuals exposed to human coronaviruses and other respiratory viruses with values ranging from 85–100%.
T188 999-1215 Sentence denotes Similar to our findings, the performance of the Liaison SARS-CoV-2 S1/S2 IgG (DiaSorin) was worst with a sensitivity of 81% (compared to 59% in our results) and specificity of 90% (compared with 100% in our results).
T189 1216-1461 Sentence denotes The group of Haselmann et al [16]. evaluated the performance of two IgG ELISA assays and one IgG electrochemiluminescence immunoassay (ECLIA) based on 51 serum samples from 26 COVID-19 patients and another 51 serum samples from control patients.
T190 1462-1525 Sentence denotes They report a sensitivity of 92–100% and specificity of 84–96%.
T191 1526-1849 Sentence denotes The Austrian Red Cross Blood Service [15] evaluated 100 SARS-CoV-2 convalescent plasma donors and SARS-CoV-2 antibodies were characterized using three different IgG-ELISAs (EUROIMMUN IgG and NCP-IgG ELISA, Wantai ELISA), two CLIA (Elecsys, LIAISON) and two lateral flow tests (MEDsan IgM/IgG-Rapid-Test, Wantai Rapid Test).
T192 1850-1960 Sentence denotes The Wantai ELISA and the Elecsys provided the highest sensitivities in this sample (98 and 95 % respectively).
T193 1961-2173 Sentence denotes Serrano et al [18]. compared the performance of 3 lateral flow immunoassays (IgM/IgG combined) to 2 ELISAs (IgA and IgG) in serum samples from 109 RT-PCR confirmed patients in different weeks after symptom onset.
T194 2174-2248 Sentence denotes The IgA ELISA was most sensitive the first week after symptom onset (71%).
T195 2249-2314 Sentence denotes The sensitivity improved to 97% for IgA ELISA in the second week.
T196 2315-2416 Sentence denotes In the third week IgA ELISA, IgG ELISA and 2 out 3 IgG lateral flow tests had a sensitivity of > 96%.
T197 2417-2476 Sentence denotes The lateral flow immunoassays showed variable performances.
T198 2477-2608 Sentence denotes Pieri et al. also found that IgA detected by the ELISA assay might be a more reliable and stable early serological marker than IgM.
T199 2609-2695 Sentence denotes Instead, IgG, as expected, showed stable level after 10 days from symptoms onset [21].
T200 2696-2752 Sentence denotes These findings are in accordance with our study results.
T201 2753-2813 Sentence denotes Serological tests could be useful in some clinical settings.
T202 2814-2927 Sentence denotes In our database, we found an added diagnostic value of serological assays in 2% of the COVID-19 suspect patients.
T203 2928-3076 Sentence denotes Although the detection of SARS-CoV-2 antibodies does not provide information on the presence of the viral RNA, it confirms recent or past infection.
T204 3077-3212 Sentence denotes This is especially relevant in clinical cases where high clinical suspicion for COVID-19 which cannot be confirmed with SARS-CoV-2 PCR.
T205 3213-3388 Sentence denotes The availability of these serological tests might avoid the need for more invasive sampling methods like BAL in the pursuit of diagnostic confirmation of COVID-19, especially.
T206 3389-3454 Sentence denotes Furthermore, serology can aid in infection prevention management.
T207 3455-3661 Sentence denotes Nuccetelli et al. suggest screening flowcharts for asymptomatic workers that is based on serological assays, workers that have already overcome the disease are subjected to molecular screening methods [22].
T208 3662-3796 Sentence denotes Next the development of antigen detection assays are underway, which have the potential to rapidly detect active SARS-CoV-2 infection.
T209 3797-3919 Sentence denotes As the pandemic evolves, more and more insights will be gained in the value of serology as well as antigen detection [23].
T210 3920-4003 Sentence denotes The main limitation of the current study is the limited number of samples included.
T211 4004-4171 Sentence denotes Nevertheless, this study has evaluated the performance of 14 different serological assays and therefore could provide useful information in this stage of the pandemic.
T212 4172-4317 Sentence denotes In conclusion, our findings show that sensitivity was variable but increased in a later stage of infection (at least 8 days after symptom onset).
T213 4318-4410 Sentence denotes Interpretation of the combination of IgM or IgA and IgG resulted in the highest sensitivity.
T214 4411-4622 Sentence denotes Our data suggest that virus-specific antibody detection for SARS-CoV-2 can complement molecular testing for diagnosis of COVID-19, especially for patients presenting in the 2nd week or later after symptom onset.
T215 4623-4682 Sentence denotes Larger datasets should be used to confirm current findings.