| Id |
Subject |
Object |
Predicate |
Lexical cue |
| T489 |
0-211 |
Sentence |
denotes |
In agreement, Zheng H.Y. et al. (2020) showed reduced functional activation of CD4+ T cells in severe (n = 6) than mild (n = 10) group as revealed by a lower proportion of IFN-γ and IL-2 expressing CD4+ T cells. |
| T490 |
212-311 |
Sentence |
denotes |
While IL-2 expressing CD4+ T cell population was also significantly lower in healthy vs mild group. |
| T491 |
312-492 |
Sentence |
denotes |
Further, CD8+ T cells displayed exhaustion as revealed by an increase in CTLA-4 in severe cases than mild and TGIT in severe than healthy, while PD-1 was more in mild than healthy. |
| T492 |
493-605 |
Sentence |
denotes |
Exhaustive states of both CD4+ and CD8+ T cells were also present in patients requiring ICU (Diao et al., 2020). |
| T493 |
606-737 |
Sentence |
denotes |
The exhaustive state was apparent by an increase in PD-1 and Tim-3 expression, which was more pronounced in CD8+ than CD4+ T cells. |
| T494 |
738-1080 |
Sentence |
denotes |
These studies along with others thus suggest that robust activation followed by the exhaustion of CD4+ and CD8+ T cells may be responsible for the disease progression, while therapies like checkpoint inhibitors (anti-PD-1 antibody; NCT04268537) which may prevent T cell exhaustion and restore their functional state may benefit some patients. |
| T495 |
1081-1179 |
Sentence |
denotes |
More studies are necessary before using such an approach can be used for therapeutic intervention. |
