| Id |
Subject |
Object |
Predicate |
Lexical cue |
| T526 |
165-376 |
Sentence |
denotes |
Whereas most IAV HAs prefer the most common Sia, Neu5Ac, over Neu5Gc as a receptor [192], HCoV-OC43 and -HKU1 S1-NTDs recognize Neu5Ac modified with an O-acetyl group at the C9-position (R1), Neu5,9Ac2 [92,193]. |
| T527 |
377-590 |
Sentence |
denotes |
It is well known that sialyl linkage at the C2-position (R2) is a key host determinant of IAVs and that change of their binding preference from α2,3 to α2,6 is a critical factor of avian-to-human host switch [10]. |
| T528 |
591-792 |
Sentence |
denotes |
In contrast, there has not been sufficient study on the linkage specificity of HCoV-OC43 and -HKU1 binding, although it is known that HCoV-43 can bind to Neu5,9Ac2α2,6Galβ1,4GlcNAc (9-O-Ac-6SLN) [193]. |
| T529 |
793-922 |
Sentence |
denotes |
Distinct from β1CoVs, additional O-acetylation at the C7 or C9-position to Neu5Ac impedes the binding of MERS-CoV (β3CoVs) [112]. |
| T530 |
923-1036 |
Sentence |
denotes |
Like avian IAV HAs, MERS-CoV S1-NTD prefers Neu5Ac linked to α2,3 over α2,6 [148]. (b) Protein receptors of CoVs. |
| T531 |
1037-1197 |
Sentence |
denotes |
Only virus binding site (VBS), receptor amino acids covering the area of the interface between the protein receptor and the indicated viral S1-CTD, are colored. |
| T532 |
1198-1201 |
Sentence |
denotes |
Ac. |
| T533 |
1202-1670 |
Sentence |
denotes |
No., accession number; BatHa, Hipposideros armiger; camelCd, Camelus dromedaries, batHa, Hipposideros armiger (Ac.No., XP_019522954.1); batRs, Rhinolophus sinicus (Ac.No., AGZ48803.1); batRf, Rhinolophus ferrumequinum (Ac.No., XP_032963186.1); civet, Paguma larvata (Ac.No., AAX63775.1); pangolin, Manis javanica (Ac.No., XP_017505752.1); human ACE2 (Ac.No., ACT66268); NL, NL63; S1, SARS-CoV; S2, SARS-CoV-2; batTp, Tylonycteris pachypus; camelCb, Camelus bactrianus. |
| T534 |
1671-1677 |
Sentence |
denotes |
Right: |
| T535 |
1678-1770 |
Sentence |
denotes |
Sialyl glycan structure and top view and side view of surface diagrams of protein receptors. |
| T536 |
1771-1840 |
Sentence |
denotes |
VBSs are colored according to the aa sequences on the left-hand side. |
| T537 |
1841-1895 |
Sentence |
denotes |
6u7e, 6m17, 1pfq are from [194,195,196], respectively. |
