| Id |
Subject |
Object |
Predicate |
Lexical cue |
| T435 |
0-168 |
Sentence |
denotes |
Recently, Qing et al. [113] demonstrated roles of S1A domains binding to Sia receptors and S1B domains binding to DDP4 receptors at different stages of virus infection. |
| T436 |
169-339 |
Sentence |
denotes |
At the initial infection stage, MERS-CoV attaches to sialyl receptors on the host cell membrane and requires subsequent durable adherence to DDP4 receptors for infection. |
| T437 |
340-521 |
Sentence |
denotes |
At later infection stages, MERS-CoV S proteins, which are not incorporated into progeny viruses, abundant on infected cell membranes attach to sialyl receptors on neighboring cells. |
| T438 |
522-723 |
Sentence |
denotes |
This stage does not require DPP4 receptors but requires the cell surface protease TMPRSS2 for activating MERS-CoV S proteins for cell-cell fusions resulting in syncytial formation that rapidly spreads. |
| T439 |
724-970 |
Sentence |
denotes |
These findings indicate the importance of Sia attachment playing roles in both initial and later infection stages and possibly determining the site of MERS-CoV infection since Sia attachment precedes DPP4 adherence at the initial infection stage. |
