| Id |
Subject |
Object |
Predicate |
Lexical cue |
| T224 |
0-281 |
Sentence |
denotes |
In addition to having high levels of cell-free DNA, myeloperoxidase-DNA, and citrullinated histone H3 – important markers of neutrophil extracellular traps (NETs) –, the serum of COVID-19-positive patients was able to strongly trigger NETosis in healthy neutrophils in vitro (164). |
| T225 |
282-571 |
Sentence |
denotes |
Despite representing important strategies to eliminate pathogens by neutrophils, NETs damage healthy tissue and induce inflammation (165), in addition to featuring a variety of oxidizing agents and being involved in several vascular diseases, as well as pathogen-induced acute lung injury. |
| T226 |
572-821 |
Sentence |
denotes |
The release of NETs by neutrophils can be triggered by several factors, such as virus-damaged epithelial cells, activated platelets, activated endothelial cells, and inflammatory cytokines, such as IL-1β, IL-8, and G-CSF, among others (95, 166–169). |
| T227 |
822-962 |
Sentence |
denotes |
In this context, it is fundamental to conduct studies assessing the role of neutrophils and NETs to better understand COVID-19 pathogenesis. |
