In addition to having high levels of cell-free DNA, myeloperoxidase-DNA, and citrullinated histone H3 – important markers of neutrophil extracellular traps (NETs) –, the serum of COVID-19-positive patients was able to strongly trigger NETosis in healthy neutrophils in vitro (164). Despite representing important strategies to eliminate pathogens by neutrophils, NETs damage healthy tissue and induce inflammation (165), in addition to featuring a variety of oxidizing agents and being involved in several vascular diseases, as well as pathogen-induced acute lung injury. The release of NETs by neutrophils can be triggered by several factors, such as virus-damaged epithelial cells, activated platelets, activated endothelial cells, and inflammatory cytokines, such as IL-1β, IL-8, and G-CSF, among others (95, 166–169). In this context, it is fundamental to conduct studies assessing the role of neutrophils and NETs to better understand COVID-19 pathogenesis.