| Id |
Subject |
Object |
Predicate |
Lexical cue |
| T86 |
0-199 |
Sentence |
denotes |
The entry mechanism of CoVs in host cells depends on the strain and species considered, as well as tissue and cell-type specificities (receptor/protease availability and local microenvironment) (58). |
| T87 |
200-394 |
Sentence |
denotes |
After binding to a target host cell via interactions with cellular receptors, viral entry of CoVs can occur in two manners: (i) the endosomal pathway and (ii) the non-endosomal pathway (59, 60). |
| T88 |
395-629 |
Sentence |
denotes |
The endosomal pathway is facilitated by low pH and pH-dependent endosomal cysteine protease cathepsins, helping to overcome the energetically unfavorable membrane fusion reaction and facilitating endosomal cell entry of CoVs (61, 62). |
| T89 |
630-747 |
Sentence |
denotes |
The non-endosomal pathway is dependent on TMPRSS2, which allows the activation of the S protein for viral entry (63). |
