| Id |
Subject |
Object |
Predicate |
Lexical cue |
| T74 |
0-158 |
Sentence |
denotes |
The S protein of SARS-CoV-2 plays an important role in determining tropism for being able to activate receptors in host cells and induce the invasion process. |
| T75 |
159-311 |
Sentence |
denotes |
This protein is cleaved by proteases into the S1 and S2 subunits, which are responsible for receptor recognition and membrane fusion, respectively (39). |
| T76 |
312-670 |
Sentence |
denotes |
Several articles have experimentally demonstrated that the RDB in the S protein, especially in the S1 region, binds to the peptidase domain (PD) of the ACE2 receptor, which is part of the renin-angiotensin-aldosterone system, an enzyme present in the plasma membrane mainly of pulmonary, endothelial, cardiac, renal, and intestinal cells (7, 22, 38, 49, 50). |
| T77 |
671-824 |
Sentence |
denotes |
The S2 subunit is known to contain the fusion peptide, in which it is inserted into the host cell membrane to trigger the fusogenic reaction (7, 51, 52). |
| T78 |
825-963 |
Sentence |
denotes |
The interaction of the S glycoprotein with the CD26 receptor and CD209L (39, 53, 54) is also suggested, however, its role remains unclear. |
