Id |
Subject |
Object |
Predicate |
Lexical cue |
T150 |
0-119 |
Sentence |
denotes |
Table 1 Differentially Expressed Proteins Identified by iTRAQ Analysis of IPEC-J2 Cells in Response to PDCoV Infection |
T151 |
120-242 |
Sentence |
denotes |
protein name Uniprot accession no. log2 ratios (infection/control) peptides sequence coverage (%) p-values functions |
T152 |
243-287 |
Sentence |
denotes |
Upregulated proteins in PDCoV-infected cells |
T153 |
288-412 |
Sentence |
denotes |
ISG15 ubiqutin-like modifier I3LU39 1.24 18 30.1 3.62 × 10–06 RIG-1/MDA5 mediated induction of IFN-alpha/beta pathways |
T154 |
413-509 |
Sentence |
denotes |
Interferon-stimulated protein 60 F1SCY2 1.09 5 14.6 3.51 × 10–05 Defense response to virus |
T155 |
510-599 |
Sentence |
denotes |
2′-5′ oligoadenylates synthetase 1, OAS1 F1RJN6 0.81 2 3.1 0.0001 Antiviral protein |
T156 |
600-721 |
Sentence |
denotes |
Radical S-adenosyl methionine domain-containing protein 2 F1S9L2 0.70 6 13.8 1.60 × 10–05 Defense response to virus |
T157 |
722-859 |
Sentence |
denotes |
Interferon induced protein with tetratricopeptide repeats 1, IFIT1 K7GN56 0.70 5 9.6 0.0002 Regulation of defense response to virus |
T158 |
860-942 |
Sentence |
denotes |
Family with sequence similarity 8 member A1 F1RUH9 0.69 1 2.2 0.0103 unknown |
T159 |
943-1006 |
Sentence |
denotes |
uncharacterized protein I3LH89 0.658 1 4.7 0.0074 unknown |
T160 |
1007-1136 |
Sentence |
denotes |
Interferon-induced GTP-binding protein Mx1 K7GKN2 0.58 2 2.0 0.0013 GTPase activity; cellular response to type I interferon |
T161 |
1137-1218 |
Sentence |
denotes |
Nucleoporin 37 (NUP37) F1SRJ4 0.57 1 5.2 0.0016 Transporting macromolecules |
T162 |
1219-1341 |
Sentence |
denotes |
Nuclear transcription factor Y submit beta (NFYB) F1SG36 0.55 2 6.3 0.0013 DNA-binding transcription factor activity |
T163 |
1342-1456 |
Sentence |
denotes |
DNA excision repair protein ERCC-6-like isoform a (ERCC6L) I3LFY4 0.45 1 0.8 0.0496 DNA translocase activity |
T164 |
1457-1567 |
Sentence |
denotes |
Collagen type IV alpha 1 chain F1RLM1 0.45 1 0.6 0.0153 Component of glomerular basement membranes (GBM) |
T165 |
1568-1638 |
Sentence |
denotes |
Ribouclease T2 F1SBX8 0.35 2 4.4 0.0004 Ribinuclease T2 activity |
T166 |
1639-1689 |
Sentence |
denotes |
MRPL32 I3LTC4 0.34 1 11.7 0.0472 translation |
T167 |
1690-1751 |
Sentence |
denotes |
Phostensin Q767M0 0.32 3 6.8 0.0047 Phosphatase binding |
T168 |
1752-1831 |
Sentence |
denotes |
Bridging integrator 1 F1RXZ6 0.32 7 22.7 0.0012 Regulation of endocytosis |
T169 |
1832-1931 |
Sentence |
denotes |
Terpene cyclase/mutase family member I3L7C2 0.29 10 16.7 0.0012 Beta-amyrin synthase activity |
T170 |
1932-1998 |
Sentence |
denotes |
Secretagogin (SCGN) Q06A97 0.28 2 9.4 0.0214 Calcium binding |
T171 |
1999-2137 |
Sentence |
denotes |
Interleukin 13 receptor subunit alpha 2 K7GSC6 0.28 2 14.6 0.0370 Obsolete signal transducer activity and cytokine receptor activity |
T172 |
2138-2229 |
Sentence |
denotes |
FOS-like 1 (FOSL1) F1RU26 0.28 1 6.2 0.0214 DNA-binding transcription factor activity |
T173 |
2230-2324 |
Sentence |
denotes |
Prolactin regulatory element binding F1SED4 0.27 9 10.1 0.0229 GTPase activator activity |
T174 |
2325-2436 |
Sentence |
denotes |
CDK-activating kinase assembly factor MAT1 (MNAT1) F6Q8T7 0.27 1 6.4 0.0076 DNA-dependent ATPase activity |
T175 |
2437-2511 |
Sentence |
denotes |
Intraflagellar transport 81 F1RNN4 0.26 1 3.7 0.0033 Tubulin binding |
T176 |
2512-2558 |
Sentence |
denotes |
Downregulated proteins in PDCoV-infected cells |
T177 |
2559-2661 |
Sentence |
denotes |
Very low density lipoprotein receptor (VLDLR) E7CXS1 –0.27 21 22.8 0.0001 Apolipoprotein binding |
T178 |
2662-2717 |
Sentence |
denotes |
uncharacterized I3LFU8 –0.27 3 5.6 0.0218 unknown |
T179 |
2718-2788 |
Sentence |
denotes |
Myeloid leukemia factor 2 F1SLT1 –0.28 6 15.8 0.0488 DNA-binding |
T180 |
2789-2892 |
Sentence |
denotes |
Helicase-like transcription factor (HLTF) I3LM88 –0.28 1 1.9 0.0254 DNA-dependent ATPase activity |
T181 |
2893-2995 |
Sentence |
denotes |
Ras association domain family member 6 F1RUL8 –0.29 2 5.5 0.0011 Regulation of apoptotic process |
T182 |
2996-3104 |
Sentence |
denotes |
Nucleoside diphosphate kinase 7 (NME7) F1RPV8 –0.29 3 8.0 0.0279 Synthesis of nucleoside triphosphates |
T183 |
3105-3236 |
Sentence |
denotes |
Bromodomain adjacent to zinc finger domain 2A (BAZ2A) F1SLA2 –0.29 1 1.2 0.0189 Component of the nucleolar remodeling complex |
T184 |
3237-3314 |
Sentence |
denotes |
BMP2 inducible kinase I3LT15 –0.29 1 2.8 0.0319 Protein kinase activity |
T185 |
3315-3386 |
Sentence |
denotes |
RNA helicase (DDX55) F1RFL5 –0.29 1 1.5 0.0274 Catalytic activity |
T186 |
3387-3445 |
Sentence |
denotes |
TMEM55B F1S8H7 –0.29 1 3.9 0.0445 Catalytic activity |
T187 |
3446-3553 |
Sentence |
denotes |
Chromatin assembly factor 1 subunit A (CHAF1A) F1S7L7 –0.29 4 5.3 0.0252 Chromo shadow domain binding |
T188 |
3554-3695 |
Sentence |
denotes |
RNA polymerase II subunit A C-terminal domain phosphatase (CTDP1) F1RWS7 –0.29 2 5.5 0.0123 Promoting the activity of RNA polymerase II |
T189 |
3696-3752 |
Sentence |
denotes |
uncharacterized I3LIB8 –0.30 2 14.7 0.0373 unknown |
T190 |
3753-3867 |
Sentence |
denotes |
Intraflagellar transport 172 I3LPC6 –0.30 1 0.69 0.0383 Negative regulation of epithelial cell proliferation |
T191 |
3868-3964 |
Sentence |
denotes |
Myocyte enhancer factor 2D (MEF2D) F1RP31 –0.30 1 1.9 0.0418 Protein dimerization activity |
T192 |
3965-4069 |
Sentence |
denotes |
Poly(ADP-ribose) glycohydrolase F1SDW4 –0.31 1 1.3 0.0355 Poly(ADP-ribose) glycohydrolase activity |
T193 |
4070-4177 |
Sentence |
denotes |
Mitogen-activated protein kinase 4 F1STG5 –0.31 4 4.9 0.0233 Protein serine/threonine kinase activity |
T194 |
4178-4289 |
Sentence |
denotes |
Anaphase promoting complex subunit 7 (ANAPC7) I3L7Q8 –0.31 4 7.9 0.0218 Ubiquitin protein ligase activity |
T195 |
4290-4386 |
Sentence |
denotes |
Transmembrane protein 45A F1SKZ6 –0.31 1 3.6 0.0191 Modulates cancer cell chemosensitivity |
T196 |
4387-4476 |
Sentence |
denotes |
Katanin p60 ATPase-containing subunit A1 I3LVP8 –0.32 2 32.1 0.0181 ATPase activity |
T197 |
4477-4564 |
Sentence |
denotes |
Ubiquitin associated protein 2 (UBAP2) F1SEA5 –0.32 1 1.7 0.0237 Cadherin binding |
T198 |
4565-4700 |
Sentence |
denotes |
Ribosomal RNA adenine dimethylase domain containing 1 F1RHJ0 –0.32 1 2.3 0.0391 rRNA (adenine-N6,N6)-dimethyltransferase activity |
T199 |
4701-4797 |
Sentence |
denotes |
Lemur tyrosine kinase 2 F1RFL2 –0.32 1 1.0 0.0104 Protein serine/threonine kinase activity |
T200 |
4798-4938 |
Sentence |
denotes |
Poly(ADP-ribose) polymerase family member 10 F1RSK9 –0.32 1 1.8 0.0182 K63-linked polyubiquitin modification-dependent protein binding |
T201 |
4939-5034 |
Sentence |
denotes |
CDK9 C9E1C9 –0.32 4 11.0 0.0183 Cyclin-dependent protein serine/threonine kinase activity |
T202 |
5035-5125 |
Sentence |
denotes |
Cystatin C Q0Z8R0 –0.33 2 17.1 0.0282 Cysteine-type endopeptidase inhibitor activity |
T203 |
5126-5247 |
Sentence |
denotes |
Cyclin and CBS domain divalent metal cation transport mediator 2 F1S849 –0.33 1 1.1 0.0173 Adenylnucleotide binding |
T204 |
5248-5352 |
Sentence |
denotes |
Protein-serine/threonine kinase F1S069 –0.34 4 8.2 0.0247 Protein serine/threonine kinase activity |
T205 |
5353-5456 |
Sentence |
denotes |
Aamy domain-containing protein F1S5K2 –0.34 1 2.5 0.0390 Catalytic activity; amino acid transport |
T206 |
5457-5578 |
Sentence |
denotes |
GATOR complex protein WDR24 I3LF05 –0.34 1 1.4 0.0368 Regulation of autophagy; positive regulation of TOR signaling |
T207 |
5579-5683 |
Sentence |
denotes |
CD109 antigen isoform 1 preproprotein K7GKY0 –0.35 18 12.9 0.0105 Endopeptidase inhibitor activity |
T208 |
5684-5788 |
Sentence |
denotes |
Nonspecific serine/threonine protein kinase (AKT2) G9BWQ2 –0.35 7 12.0 0.0310 Transferase activity |
T209 |
5789-5885 |
Sentence |
denotes |
DNA polymerase delta interacting protein 3 (POLDIP3) F1SJQ4 –0.35 3 3.8 0.0287 RNA binding |
T210 |
5886-5975 |
Sentence |
denotes |
Exostosin-like glycosyltransferase 2 F1S568 –0.35 1 3.3 0.0215 Transferase activity |
T211 |
5976-6107 |
Sentence |
denotes |
4F5 domain-containing protein I3LS25 –0.36 9 42.4 0.0015 Positive regulator of amyloid protein aggregation and proteotoxicity |
T212 |
6108-6243 |
Sentence |
denotes |
Integrator complex subunit 4 (INTS4) F1STY6 –0.37 3 2.4 0.0429 Involved in the small nuclear RNAs (snRNA) U1 and U2 transcription |
T213 |
6244-6325 |
Sentence |
denotes |
Smoothelin-like 2 F1RGN8 –0.37 1 2.7 0.0119 Actin cytoskeleton organization |
T214 |
6326-6427 |
Sentence |
denotes |
Elongation of very long chain fatty acids protein I3L7S8 –0.39 1 21.6 0.0444 Catalytic activity |
T215 |
6428-6483 |
Sentence |
denotes |
uncharacterized I3LBD1 –0.40 1 7.4 0.0085 unknown |
T216 |
6484-6580 |
Sentence |
denotes |
Secretory carrier-associated membrane protein F1SJ46 –0.41 7 13.1 0.0144 Protein transport |
T217 |
6581-6643 |
Sentence |
denotes |
Cadherin 6 F1SP42 –0.42 3 3.7 0.0122 Calcium ion binding |
T218 |
6644-6726 |
Sentence |
denotes |
Superoxide dismutase I3LUD1 –0.43 2 4.9 0.0139 Superoxide dismutase activity |
T219 |
6727-6856 |
Sentence |
denotes |
Probable ribosome biogenesis protein C16orf42 homologue (SMARCA2) F1RFZ6 –0.44 1 4.4 0.0470 Involved in ribosome biogenesis |
T220 |
6857-6996 |
Sentence |
denotes |
Protein zyg-11 homologue B F1S6I1 –0.45 1 3.4 0.0030 Positive regulation of proteasomal ubiquitin-dependent protein catabolic process |
T221 |
6997-7089 |
Sentence |
denotes |
BCL2 interacting protein 3 I3LDJ9 –0.45 2 6.6 0.0009 Protein homodimerization activity |
T222 |
7090-7199 |
Sentence |
denotes |
Alpha-(1,6)-fucosyltransferase (FUT8) F1SA54 –0.47 1 3.3 0.0492 Alpha-(1→6)-fucosyltransferase activity |
T223 |
7200-7298 |
Sentence |
denotes |
Signal peptide peptidase-like 2B F1S8G9 –0.52 2 1.9 0.0190 Protein homodimerization activity |
T224 |
7299-7385 |
Sentence |
denotes |
INTS3 and NABP interacting protein (INTS4) F1SNA6 –0.54 5 12.5 0.0006 DNA repair |
T225 |
7386-7480 |
Sentence |
denotes |
Trypsin domain containing 1 F1SUE6 –0.55 1 1.8 0.0215 Serine-type endopeptidase activity |
T226 |
7481-7601 |
Sentence |
denotes |
UDP-glucose glycoprotein glucosyltransferase 2 F1RP50 –0.62 2 2.3 0.0320 Glycoprotein glucosyltransferase activity |
T227 |
7602-7693 |
Sentence |
denotes |
Phosphatidylglycerophosphate synthase 1 I3LN95 –0.62 1 2.7 0.0440 Calcium ion binding |
T228 |
7694-7763 |
Sentence |
denotes |
Metallothionein-2A P79379 –0.63 9 32.8 0.0017 Metal ion binding |
T229 |
7764-7819 |
Sentence |
denotes |
uncharacterized I3LNY1 –0.66 1 6.5 0.0246 unknown |
T230 |
7820-7884 |
Sentence |
denotes |
Formin-like 1 I3LH80 –0.83 1 1.8 0.0191 Rho GTPase binding |
T231 |
7885-7941 |
Sentence |
denotes |
uncharacterized K7GL96 –1.13 1 10.9 0.0412 unknown |