| Id |
Subject |
Object |
Predicate |
Lexical cue |
| T242 |
0-285 |
Sentence |
denotes |
The antioxidant activity of royal jelly and CAPE might be related to their strong capacity to activate the master redox-active NRF2 signaling pathway [73,122], which stimulates the production of internal antioxidants such as heme oxygenase-1 (HO-1), which scavenge free radicals [123]. |
| T243 |
286-391 |
Sentence |
denotes |
Meanwhile, NRF2 and HO-1 block ROS production indirectly via suppression of inflammatory reactions [122]. |
| T244 |
392-584 |
Sentence |
denotes |
In this context, CAPE reduced degenerative myopathy in rats on eccentric exercise via a complex mechanism that involved inhibition of NF-κB and its downstream pro-oxidant COX-2 and iNOS [101]. |
| T245 |
585-842 |
Sentence |
denotes |
Correspondingly, CAPE decreased markers of oxidative cellular damages (protein carbonyl, protein nitrosylation, xanthine oxidase, and adenosine deaminase) associated with ischemia reperfusion and eccentric exercise in the gastrocnemius muscle [101,102,103]. |
| T246 |
843-1048 |
Sentence |
denotes |
In this regard, CAPE operated via a mechanism that involved inhibition of neutrophil and leukocyte infiltration into the gastrocnemius muscle, which was associated with decreased levels of myeloperoxidase. |
| T247 |
1049-1220 |
Sentence |
denotes |
Myeloperoxidase contributes to excessive production of ROS and oxidative organ damage through a mechanism that embroils increased synthesis of hypochlorous acid [101,102]. |
| T248 |
1221-1390 |
Sentence |
denotes |
Furthermore, CAPE accelerated purine salvage for ATP synthesis and inhibited ROS-induced lipid peroxidation via attenuation of the activity of adenosine deaminase [102]. |
