LitCovid-sentences  

PMC:7601109 / 30658-32614 JSONTXT 10 Projects

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Id Subject Object Predicate Lexical cue
T201 0-83 Sentence denotes The role that inflammation plays in skeletal muscle is not quite clear as it looks.
T202 84-148 Sentence denotes Inflammatory mediators behave in a dual fashion in muscle cells.
T203 149-299 Sentence denotes During injury, cytokines and chemokines stimulate muscle repair and regeneration via activation of myoblasts, a core event in muscle remodeling [108].
T204 300-459 Sentence denotes Similarly, serum and muscle levels of IL-6 temporarily increase following physical exercise, and IL-6 blocks the activity of catabolic cytokines such as TNF-α.
T205 460-734 Sentence denotes On the other hand, chronic inflammation in muscle cells, which correlates with persistent mitochondrial dysfunction and metabolic dysregulation, pathologically activates muscle fiber transformation and atrophy, eventually resulting in the development of sarcopenia [23,114].
T206 735-927 Sentence denotes It seems that bee products also act dually in skeletal muscle: they support the activity of cytokines that promote muscle remodeling [108] and suppress muscle-consuming cytokines [38,101,108].
T207 928-1331 Sentence denotes In this regard, treating undifferentiated C2C12 myoblasts with ethanolic extracts of Brazilian propolis (100 μg/mL for 8 h) triggered the migration of RAW264 macrophage and increased their production of angiogenic factors (e.g., vascular endothelial growth factor A (VEGF-A) and metalloproteinase-12 (MMP-12)), chemokines (e.g., CCL-2 and CCL-5), and cytokines (e.g., IL-6, which increased by 40-folds).
T208 1332-1417 Sentence denotes Propolis inhibited the expression of IL-1β and TNF-α at 4, 8, and 12 h of incubation.
T209 1418-1595 Sentence denotes These effects were nuclear factor kappa B (NF-κB)-dependent given that propolis simultaneously increased nuclear translocation of p65 and p50 NF-κB proteins 3 h after treatment.
T210 1596-1771 Sentence denotes Meanwhile, inhibiting IκB kinase (IKK) by BMS-345541 profoundly hindered the effect of propolis on the expression of CCL-2, CCL-5, and IL-6 by 66%, 81%, and 69%, respectively.
T211 1772-1823 Sentence denotes Propolis also enhanced the expression of MAIL/IκBζ.
T212 1824-1956 Sentence denotes This molecule modulates chromatin and selectively induces the production of IL-6, leukemia inhibitory factor (LIF), and CCL-2 [108].