LitCovid-sentences  

PMC:7600245 / 55111-56488 JSONTXT 10 Projects

Annnotations TAB TSV DIC JSON TextAE

Id Subject Object Predicate Lexical cue
T409 0-4 Sentence denotes 4.7.
T410 5-24 Sentence denotes Leflunomide (Arava)
T411 25-111 Sentence denotes It is a synthetic, small molecule and an isoxazole-carboxamide derivative (Figure 8B).
T412 112-139 Sentence denotes It was approved by the U.S.
T413 140-213 Sentence denotes FDA in 1998 for the oral treatment of rheumatoid arthritis [173,174,175].
T414 214-420 Sentence denotes It is also used off-label as a replacement therapy in kidney transplant recipients with polyomavirus BK [176] and for cytomegalovirus disease in transplant recipients resistant to standard antivirals [177].
T415 421-523 Sentence denotes Mechanistically, it is a disease-modifying agent with anti-inflammatory and antiproliferative effects.
T416 524-702 Sentence denotes It inhibits pyrimidine synthesis by inhibiting the mitochondrial enzyme dihydroorotate dehydrogenase, an important enzyme in the de novo synthesis of uridine monophosphate [178].
T417 703-842 Sentence denotes Leflunomide is a prodrug and the active metabolite (isoxazole ring is open: teriflunomide (Aubagio)) is responsible for its activity [179].
T418 843-904 Sentence denotes It inhibits rapidly dividing cells such as activated T cells.
T419 905-968 Sentence denotes It has also been found to block the transcription factor NF-κB.
T420 969-1010 Sentence denotes It also inhibits tyrosine kinase enzymes.
T421 1011-1182 Sentence denotes The drug inhibits the replication of cytomegalovirus, herpes simplex virus 1, and polyomavirus BK by interfering with nucleocapsid tegumentation and virion assembly [179].
T422 1183-1377 Sentence denotes Given the above activities, a high dose of leflunomide is being evaluated for the treatment of ambulatory patients with mild COVID-19 at the University of Chicago Medicine (NCT04361214; n = 20).